[1]段秀枝,金苑卿.健康人群血清PG定量检测和Hp感染的临床意义[J].现代检验医学杂志,2016,31(02):26-28,31.[doi:10.3969/j.issn.1671-7414.2016.02.008]
　DUAN Xiu-zhi,JIN Yuan-qing.Clinical Meaning of Pepsinogen Test and Helicobacter Pylori Serology in the Health Check-up Population[J].Journal of Modern Laboratory Medicine,2016,31(02):26-28,31.[doi:10.3969/j.issn.1671-7414.2016.02.008]
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健康人群血清PG定量检测和Hp感染的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年02期
页码:
26-28,31
栏目:
论著
出版日期:
2016-06-01

文章信息/Info

Title:
Clinical Meaning of Pepsinogen Test and Helicobacter Pylori Serology in the Health Check-up Population
作者:
段秀枝; 金苑卿
浙江大学医学院附属第二医院检验科,杭州 310009
Author(s):
DUAN Xiu-zhi; JIN Yuan-qing
Department of Laboratory Medicine,the Second Affiliated Hospital of Medical School,Zhejiang University,Hangzhou 310009,China
关键词:
胃蛋白酶原;  幽门螺杆菌感染;  健康人群
分类号:
R378; R446.11
DOI:
10.3969/j.issn.1671-7414.2016.02.008
文献标志码:
A
摘要:
目的 探讨健康体检人群的血清胃蛋白酶原(PG)与幽门螺杆菌(Hp)现症感染状况的关系。评估年龄、性别和幽门螺杆菌状态对胃蛋白酶原检测的影响以及建立胃蛋白酶原检测结果和幽门螺杆菌血清学检测在健康体检人群中的临床应用。方法 采用胶体金法对800例查体者进行Hp感染检测。采用化学发光微粒子免疫检测法进行血清PGI和PGII测定并计算PGI/II比值,定量检测人血清或血浆中的PG水平。结果 体检人群Hp感染率为50.63%; 性别与Hp感染率差异无统计学显著性意义(P>0.05); 年龄段与Hp感染率差异有统计学显著性意义(P<0.05),40～60岁Hp阳性率最高; 血清PGI和PGII水平在Hp阳性者中高于Hp阴性者(P<0.05)。PGI/II比值在Hp阳性者中低于Hp阴性者(P<0.05)。结论 健康体检人群中,年龄、性别和Hp感染状态与血清PG水平有一定关联。 其中Hp感染状况与血清PG水平及PG异常率密切相关,因此Hp与PG水平检测相结合可用于健康体检人群的普查筛选。
Abstract:
Objective To explore the relationship between the status of infection of levels of serum pepsinogen(PG)and Helicobacter pylori(Hp)in the health check-up group.To assess the affects of age,sex,andHp status on PG testing and to establish the clinical implications of PG test results and Hp in the health check-up population.Methods Using colloidal gold mining Hp IgG antibodies test kit detected 800 health population.Using chemiluminescence immune assay determinated serum PGI and PGII particles and calculate the PGI/II ratio in the serum or plasma.Results Hp infection rate of population health people for 50.63%.There was no significant difference in gender and Hp infection rate(P>0.05).Ageand Hp infection rate had significant difference(P<0.05).Hp positive ratewas highest at the age of 40 to 60.The level of serum PGI and PGII Hp was higher than in the negative(P<0.05).Hp negative was lower than in Hp positiveof PGI/II ratio(P<0.05).Conclusion The age,genderand state of Hp infection associated with serum PG level in the health check-up crowd.The Hp infection status is closely related to the level and abnormal rate of serum PG,Hp combined with PG level detection could be used in the physical examination population census screening.

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备注/Memo

备注/Memo:
基金项目:浙江省自然科学基金面上项目(LY15H200002)。 作者简介:段秀枝(1985-),女,硕士研究生,初级检验师,主要研究方向:雄激素非依赖性前列腺癌的分子机制研究,Tel:1885788 0665,E-mail:duanxiuzhi@zju.edu.cn。金苑卿,并列第一作者。
更新日期/Last Update: 2016-02-20