[1]何晓璇a,王 刚a,郭 炫a,等.FIB,DD和FDP在高血压肾损伤中的变化及临床意义[J].现代检验医学杂志,2016,31(02):73-76.[doi:10.3969/j.issn.1671-7414.2016.02.022]
　HE Xiao-xuana,WANG Ganga,GUO Xuana,et al.Changes and Clinical Significance Observation on FIB, DD and FDP in Renal Impairment of Hypertension[J].Journal of Modern Laboratory Medicine,2016,31(02):73-76.[doi:10.3969/j.issn.1671-7414.2016.02.022]
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FIB,DD和FDP在高血压肾损伤中的变化及临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年02期
页码:
73-76
栏目:
论著
出版日期:
2016-06-01

文章信息/Info

Title:
Changes and Clinical Significance Observation on FIB, DD and FDP in Renal Impairment of Hypertension
作者:
何晓璇1a; 王 刚1a; 郭 炫1a; 王春林2; 肖菊香1b
1.西安交通大学第一附属医院, a.检验科; b.肿瘤内科,西安 710061; 2.深圳迈瑞生物医疗电子股份有限公司,广东深圳 518057
Author(s):
HE Xiao-xuan1a; WANG Gang1a; GUO Xuan1a; WANG Chun-lin2; XIAO Ju-xiang1b
1a.Department of Clinical Laboratory; 1b.Department ofOncology,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,710061,China; 2.Shenzhen Mindray Biomedical Electronic Limited by Share Ltd,Guangdong Shenzhen 518057,China
关键词:
纤维蛋白原;  D-二聚体;  纤维蛋白原降解产物;  高血压;  肾损伤
分类号:
R544.1; R446.112
DOI:
10.3969/j.issn.1671-7414.2016.02.022
文献标志码:
A
摘要:
目的 研究纤维蛋白原(FIB)、D-二聚体(DD)、纤维蛋白原降解产物(FDP)在高血压肾损伤中的变化及临床意义。方法 选取145例原发性高血压患者作为病例组,按24 h尿微量清蛋白(24hU-mALB)分为正常蛋白尿组、微量蛋白尿组及大量蛋白尿组; 选取同期查体的健康人44例作为正常对照组。检测各组尿素氮(BUN)、胱抑素C(Cys-C)、尿酸(UA),FIB,DD和FDP,通过统计观察其差异及相关性。结果 ①BUN,Cys-C,UA,FIB,DD和FDP在四组间比较,差异具有统计学意义(P<0.05)。正常蛋白尿组(DD,FDP),微量蛋白尿组(BUN,Cys-C,FIB,DD和FDP)及大量蛋白尿组(BUN,Cys-C,FIB,DD和FDP)与正常对照组比较,差异均具有统计学意义(Z=2.798,3.077,2.148,4.158,3.243,3.298,3.669,3.663,6.678,5.925,4.432和4.507,P<0.05); 微量蛋白尿组(BUN,Cys-C,FIB)及大量蛋白尿组(BUN,Cys-C,FIB,DD和FDP)与正常蛋白尿组比较,差异均具有统计学意义(Z=2.510,4.233,2.302,4.090,6.678,5.266,2.736和2.709,P<0.05); 大量蛋白尿组(BUN,Cys-C,FIB)与微量蛋白尿组比较,差异具有统计学意义(Z=2.355,3.587和3.839,P<0.05); 微量蛋白尿组和大量蛋白尿组与其他各组比较,UA的差异均有统计学意义(P<0.05)。②相关性分析:FIB与24hU-mALB,BUN,Cys-C和UA呈正相关(r=0.462,0.252,0.411和0.183,P<0.05); DD与24hU-mALB,BUN和Cys-C呈正相关(r=0.194,0.286和0.346,P<0.05); FDP与24hU-mALB,BUN和Cys-C呈正相关(r=0.197,0.239和0.322,P<0.05)。结论 FIB,DD和FDP在高血压肾病早期和进展期表现出不同程度的升高,能够为临床及时发现病情进展提供一定的帮助。
Abstract:
Objective To study the changes and clinical significance of coagulation-related parameters in renal injury of patients with hypertension.Methods 145 patients with essential hypertension were selected as the case group.Divided the case group into normal,microand massive proteinuria group according to the content of 24 hours urinary micro albumin(24hU-mALB).At the same time,44 healthy persons were selected as the contrast group.Cystatin C(Cys-C),uric acid(UA),urea nitrogen(BUN),fibri-nogen(FIB),D-Dimer(DD)and fibrinogen degradation products(FDP)were detected in every sample.Finding the difference and correlation by statistical analysis in each group to observe the changes and effects on FIB,DD and FDP in renalimpairment of hypertension.Results ①BUN,Cys-C,UA,FIB,DD and FDP in the comparison between the four groups,the difference appeared statistical significance(P< 0.05).Compared with the contrast group,thestatistical difference was found in DD,FDP of the normal proteinuria group,BUN,Cys-C,FIB,DD and FDP of the micro proteinuria group,and BUN,Cys-C,FIB,DD and FDP of the massive proteinuria group(Z=2.798,3.077,2.148,4.158,3.243,3.298,3.669,3.663,6.678,5.925,4.432 and 4.507,all P<0.05).Compared with the no-rmal proteinuria group,the statistical difference was showed in BUN,Cys-C and FIB of the micro proteinuria group,and BUN,Cys-C,FIB,DD,FDP of the massive proteinuria group(Z=2.510,4.233,2.302,4.090,6.678,5.266,2.736 and 2.709,all P<0.05).Compared with the micro proteinuria group,BUN,Cys-C and FIB in the massive proteinuria group appeared obviously statistical significance(Z=2.355,3.587 and 3.839,all P<0.05).Each of the micro proteinuria group and massive proteinuriagroup compared with the other groups,UA showed obviously statistical significance(P<0.05).②Correlation analysis:FIB was positively related to 24hU-mALB,BUN,Cys-C,UA(r=0.462,0.252,0.411,0.183,all P<0.05).DDwas positively related to 24hU-mALB,BUN,Cys-C(r=0.194,0.286,0.346,all P<0.05).FDP was positively related to 24hU-mALB,BUN,Cys-C(r=0.197,0.239,0.322,all P<0.05).Conclusion FIB,DD and FDP could show different changes both in early and advanced stage of renal injury with hypertension,which can provide some help for the clinical diagnosis of disease.

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备注/Memo

备注/Memo:
作者简介:何晓璇(1985-),女,本科,检验师,主要从事临床检验诊断工作,E-mail:hexiaoxuan1029@ 163.com。 通讯作者:肖菊香,女,主任医师,硕士生导师,主要从事肿瘤内科临床与基础研究工作,E-mail:1983181726@qq.com。
更新日期/Last Update: 2016-02-20