[1]房国忠,吴 红,杨 琛.联合检测血清胃蛋白酶原和胸苷激酶1在胃部疾病诊断中的意义[J].现代检验医学杂志,2016,31(02):124-126.[doi:10.3969/j.issn.1671-7414.2016.02.037]
　FANG Guo-zhong,WU Hong,YANG Chen.Clinical Significance of Detecting Serum Pepsinogen and Thymidine Kinase 1 Levels in Patients with Gastric Diseases[J].Journal of Modern Laboratory Medicine,2016,31(02):124-126.[doi:10.3969/j.issn.1671-7414.2016.02.037]
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联合检测血清胃蛋白酶原和胸苷激酶1在胃部疾病诊断中的意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年02期
页码:
124-126
栏目:
检验与临床
出版日期:
2016-06-01

文章信息/Info

Title:
Clinical Significance of Detecting Serum Pepsinogen and Thymidine Kinase 1 Levels in Patients with Gastric Diseases
作者:
房国忠1; 吴 红2; 杨 琛1
1.天津市河东区大王庄街社区卫生服务中心检验科,天津 300171; 2.新疆生产建设兵团第二师库尔勒医院检验科,新疆库尔勒 841000
Author(s):
FANG Guo-zhong1; WU Hong2; YANG Chen1
1.Department of Clinical Laboratory,Dawangzhuang Community Medical Services Center in Tianjin City Hedong Dirtric,Tianjin 300171,China; 2.Department of Clinical Laboratory, the Second Division of Production and Construction Corps,Korla Hospital,Xinjiang K
关键词:
胃蛋白酶原;  胸苷激酶1;  胃溃疡;  胃癌
分类号:
R573; R446.112
DOI:
10.3969/j.issn.1671-7414.2016.02.037
文献标志码:
A
摘要:
目的 探讨血清胃蛋白酶原(pepsinogen,PG)含量和细胞胸苷激酶1(thymidine kinase 1,TK1)水平检测与胃部疾病诊断的关系。方法 经胃镜和病理检查诊断浅表性胃炎65例,萎缩性胃炎30例,胃溃疡35例(其中良性胃溃疡15例,恶性胃溃疡20例),胃癌20例,同期健康体检者160例。用乳胶增强免疫比浊法测定血清中的PGⅠ和PGⅡ含量,同时计算出PGⅠ/PGⅡ比值(PGR)。免疫印迹增强化学发光法测定TK1含量。结果 对照组和胃部疾病组血清PGⅠ和PGR以及TK1含量差异均有统计学意义(F=88.45～128.71,均P<0.05)。浅表性胃炎组、萎缩性胃炎组、胃溃疡组和胃癌组之间PGⅠ和PGR以及TK1含量比较差异均有统计学意义(t=16.45～38.71,t=31.25～66.32,t=3.78～8.23,均P<0.05),而PGⅡ含量比较差异无统计学意义(P>0.05)。胃溃疡恶性组TK1含量明显比良性组高,且两组比较差异有统计学意义(t=8.45,P<0.05)。结论 联合检测血清PG和TK1含量可诊断胃炎、胃溃疡和胃癌,特别能鉴别胃溃疡良恶性。
Abstract:
Objective To investigate the relationship between serum pepsinogen(PG)levels as well as thymidine kinase 1(TK1)with Gastric Diseases.Methods 150 cases were selected in the study,superficial gastritis,atrophic gastritis,gastrohelcosis and gastric carcinoma were diagnosed by endoscopy and pathology.And 160 cases were normal subjects.These were measured serum pepsingen Ⅰ,pepsinogen Ⅱlevels by lactoprene immunoturbidimetric assay and calculate PGⅠ/PGⅡratio(PGR).TK1 was detected by Chemiluminiscence assay.Results There were obvious differencesof PGⅠ,PGR and TK1 levels between gastric diseases group and normal group(F=88.45～128.71,P<0.05),however no differences of PGⅡlevel(P>0.05).There were also obviously differences among superficial gastritis group,atrophic gastritis group, gastrohelcosis group and gastric carcinoma group(t=16.45～38.71,t=31.25～66.32,t=3.78～8.23,P<0.05 and t=8.45,P<0.05).Conclusion The combined detection of PG level and TK1are valuable for diagnosis of gastritis,gastrohelcosis and gastric carcinoma and its pathological changes.It is possible for detection of serum TK1 to identify between benign gastrohelcosis and malignancy gastrohelcosis.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:房国忠(1971-),男,检验师,主要从事临床疾病的检验工作。
更新日期/Last Update: 2016-02-20