[1]程俊杰,李 静,梁西强,等.非高密度脂蛋白胆固醇 与冠心病患者心功能分级的相关性研究[J].现代检验医学杂志,2016,31(03):43-47.[doi:10.3969/j.issn.1671-7414.2016.03.012]
　CHENG Jun-jie,LI Jing,LIANG Xi-qiang,et al.Correlation between Non High Density Lipoprotein Cholesterol and Cardiac Function in Patients with Coronary Heart Disease[J].Journal of Modern Laboratory Medicine,2016,31(03):43-47.[doi:10.3969/j.issn.1671-7414.2016.03.012]
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非高密度脂蛋白胆固醇 与冠心病患者心功能分级的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年03期
页码:
43-47
栏目:
论著
出版日期:
2016-06-15

文章信息/Info

Title:
Correlation between Non High Density Lipoprotein Cholesterol and Cardiac Function in Patients with Coronary Heart Disease
文章编号:
1671-7414(2016)03-043-05
作者:
程俊杰1; 2; 李 静3; 梁西强1; 段霞霞1; 肖尧1; 郭 炫1
1.西安交通大学第一附属医院检验科,西安 710061;
2.陕西省核工业二一五医院检验科,陕西咸阳 712000;
3.西安市中心医院输血科,西安 710031
Author(s):
CHENG Jun-jie1; 2; LI Jing3; LIANG Xi-qiang1; DUAN Xia-xia1; XIAO Rao1; GUO Xuan1
1.Department of Clinical Laboratory,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China;
2.Department of Clinical Laboratory, Nuclear Industry 215 Hospital of Shaanxi Province,Shaanxi Xianyang 712000,China;
3.Departmen
关键词:
非高密度脂蛋白胆固醇;  心功能分级;  冠心病
分类号:
R541.4; R446.112
DOI:
10.3969/j.issn.1671-7414.2016.03.012
文献标志码:
A
摘要:
目的 探讨非高密度脂蛋白胆固醇(non-HLD-C)与冠心病(cardiac heart disease,CHD)患者心功能分级的相关性。方法 选取162例CHD患者为CHD实验组,并同期选取经健康体检合格者100例为正常对照组。CHD实验组按照心功能受损程度分为轻度受损组和重度受损组,其中轻度受损组包括心功能分级的I级与II级,重度受损组包括心功能分级的III级和IV级。分别测定各组总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C),并计算出非高密度脂蛋白胆固醇(non-HDL-C)的含量。比较CHD实验组与正常对照组中血脂各指标的差异性及血脂各指标与心功能受损程度的相关性。结果 CHD实验组中心功能轻度受损组血清中的TG,LDL,non-HDL-C高于正常对照组,两组间差异有统计学意义(t=2.438,2.887,5.253,P值均<0.05),CHD实验组中的心功能重度受损组血清中的TG,LDL,non-HDL-C高于正常对照组中,两组间差异有统计学意义(t=4.979,4.957,7.190,P值均<0.05),CHD实验组中心功能轻度受损组血清中的HDL较正常对照组低,两组间差异有统计学意义(t=-3.132,P<0.05),CHD实验组中心功能重度受损组血清中的HDL较正常对照组低,两组间差异有统计学意义(t=-6.028,P<0.05),CHD实验组中只有心功能重度受损组的TC与正常对照组间差异有统计学意义(t=3.278,P<0.05),CHD实验组中心功能轻度受损组的LDL,non-HDL-C,TG与重度受损组间差异有统计学意义(t=2.051,2.057,2.281,P值均<0.05)。Logistic回归分析显示,CHD组血清non-HDL-C的OR值低于LDL,高于HDL和TG,并随着心功能受损程度的增加OR值增加。结论 non-HDL-C与CHD的严重程度呈正相关,可在一定程度上反映CHD的严重程度,是CHD临床诊断与治疗的重要参考指标。
Abstract:
Objective To investigate the correlation between non high density lipoprotein cholesterol(non-HLD-C)and cardiac function in patients with coronary heart disease(heart disease cardiac,CHD).Methods 162 patients with CHD were selected as the experimental group of CHD,100 cases of healthy physical examination qualified as the normal control group.CHD experimental group was divided into mild impairment group and severe impairment group according to the degree of impairment of the heart function.The mild impairment group include I and II levels of cardiac function classification and the severe impairment group included III and IV levels of cardiac function classification.To measure separately total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoproteincholesterol(LDL-C),and to calculate the content of non high density lipoprotein cholesterol(non-HDL-C).To compare the differences between CHD experimental group and normal control group,and the correlation between different indexesof blood lipid and the degree of loss of cardiac function.ResultsThe serum levels of non-HDL-C,TG and LDL in the Cardiac function in mild damage group of the CHD experimental group were significantly higher thanthose in the normal control group,and there were statistically significant differences between the two groups(t=2.438,2.887,5.253,P<0.05).The serum levels of non-HDL-C,TG and LDL in the severe heart function impairment group of the CHD experimental group were significantly higher than those in the normal control group,and there were statistically significant differences between the two groups(t=2.438,2.887,5.253,P<0.05).The serum level of HDL inthe cardiac function in mild damage group of the CHD experimental group was significantly lower than that in the normal control group(t=-3.132,P<0.05).The serum level of HDL in the severe heart function impairment group of the CHD experimental group was significantly lower than that in the normal control group(t=-6.028,P<0.05).In the CHD group,only the serum level of TC in thesevere impairment group was significantly different from that in the control group(t=3.278,P<0.05).The serum levels of non-HDL-C,TG,LDL of mild impairment of cardiac function in the CHD experimental group were significantly different from the serum levels of the severe impairment group(t=2.051,2.057,2.281,P<0.05).Logistic regression analysed that the OR value of serum non-HDL-C in CHD group was slightly lower than that of LDL,and significantly higher than TC and TG.With the increase of the degree of cardiac function,the value of OR increased significantly.Conclusion Serumnon-HDL-C had a positive correlation with severity of CHD.To a certainextent,it can reflect the severity of CHD and is an important reference index for clinical diagnosis and treatment of CHD.

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备注/Memo

备注/Memo:
作者简介:程俊杰,硕士研究生在读,E-mail:953598984@ qq.com。 通信作者:郭 炫,主任技师,硕士研究生导师,E-mail:350449850@qq.com。
更新日期/Last Update: 2016-06-25