[1]杨建华,王炳华,林 勇.血清胃蛋白酶原和胃泌素-17 对萎缩性胃炎及胃癌患者诊断价值[J].现代检验医学杂志,2016,31(03):51-54.[doi:10.3969/j.issn.1671-7414.2016.03.014]
　YANG Jian-hua,WANG Bing-hua,LIN Yong.Clinical Value of Serum Pepsinogen and Gastrin-17 Levels in Patients with Atrophic Gastritis and Gastric Cancer[J].Journal of Modern Laboratory Medicine,2016,31(03):51-54.[doi:10.3969/j.issn.1671-7414.2016.03.014]
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血清胃蛋白酶原和胃泌素-17 对萎缩性胃炎及胃癌患者诊断价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年03期
页码:
51-54
栏目:
论著
出版日期:
2016-06-15

文章信息/Info

Title:
Clinical Value of Serum Pepsinogen and Gastrin-17 Levels in Patients with Atrophic Gastritis and Gastric Cancer
文章编号:
1671-7414(2016)03-051-04
作者:
杨建华1; 王炳华1; 林 勇1; 2
1.上海市静安区中心医院 复旦大学附属华山医院静安分院检验科,上海200040;
2.复旦大学附属华山医院检验医学科,上海 200040
Author(s):
YANG Jian-hua1; WANG Bing-hua1; LIN Yong1; 2
1.Department of Clinical Laboratory,Jing'an District Centre Hospital of Shanghai,Huashan Hospital Jing'an Branch Affiliated to Fudan University,Shanghai 200040,China;
2.Department of Laboratory Medicine,Huashan Hospital Affiliated to Fudan University
关键词:
胃蛋白酶原;  胃泌素-17;  萎缩性胃炎;  胃癌
分类号:
R573.32; R735.2; R446.112
DOI:
10.3969/j.issn.1671-7414.2016.03.014
文献标志码:
A
摘要:
目的 探索血清胃蛋白酶原(pepsinogen,PG)Ⅰ,PGⅡ和胃泌素-17(gastrin-17,G-17)对萎缩性胃炎及胃癌患者的早期临床诊断价值。方法 研究采用观察性病例-对照研究,共430例受检者纳入研究。血清测试前,受检者经活检组织病理学检查证实。根据病理结果将受检者分为非萎缩性胃炎160例、萎缩性胃炎118例、胃癌152例,用酶联免疫吸附试验方法(enzyme-linked immunosorbent assay,ELISA)检测血清PGⅠ,PGⅡ和G-17含量,并计算PGⅠ/PGⅡ比值。结果与非萎缩性胃炎组相比,萎缩性胃炎组血清PGⅠ和G-17均降低,差异具有统计学意义(P<0.05),胃癌组血清PGⅠ,PGⅡ,PGⅠ/PGⅡ及G-17均降低,差异具有统计学意义(P<0.05); 与萎缩性胃炎组相比,胃癌组血清PGⅠ和G-17均降低,差异具有统计学意义(P<0.05)。根据受试者工作特征曲线(receiver operating characteristiccurve, ROC),PGⅠ,PGⅡ,PGⅠ/PGⅡ及G-17诊断萎缩性胃炎的最佳临界值为84.706 μg/L,10.873 μg/L,11.008和8.265 pg/L,诊断胃癌的最佳临界值为65.145 μg/L,10.089 μg/L,6.375和4.971 pg/L。结论 血清PGⅠ,PGⅡ,PGⅠ/PGⅡ及G-17水平低下是萎缩性胃炎及胃癌生物学标志,对胃癌早期诊断具有重要的临床意义。
Abstract:
Objective To investigate the clinical value ofserum pepsinogen(PG)Ⅰ,Ⅱ and gastrin-17(G-17)levels in early diagnosis foratrophic gastritis and gastric cancer.Methods The studywas performed on a case-control trial,and 430 subjects were recruited.Each of them underwent endoscopy biopsies before serum tests were performed.These patients were further divided into three groups based on endoscopic and histological findings:160 non-atrophic gastritis group,118 atrophic gastritis group and152 gastric cancer group.Serum samples of PGⅠ,PGⅡ and G-17 were analyzed byenzyme-linked immunosorbent assay(ELSIA),and calculated the values of PGⅠ/PGⅡratio.Results Compared with the non-atrophic gastritis group,serum PGⅠ and G-17 values in atrophic gastritis and serum PGⅠ,PGⅡ,PGⅠ/PGⅡratio and G-17 values in gastric cancer group decreased significantly(P<0.05); compared with the atrophic gastritis group,serum PGⅠ and G-17 values in gastric cancer group decreased significantly(P<0.05).By usingreceiver operating characteristic curves(ROC),the cut-off points of PGⅠ84.706 μg/L,PGⅡ 10.873 μg/L,PGⅠ/PGⅡ ratio 11.008 and G -178.265 pg/L inatrophic gastritis group,PGⅠ65.145 μg/L,PGⅡ 10.089 μg/L,PGⅠ/PGⅡ ratio6.375 and G-17 4.971 pg/L in gastric cancer group.Conclusion Low serum PGⅠ,PGⅡ,PGⅠ/PGⅡ ratio and G-17 values are biomarkers of atrophic gastritis and gastric cancer and valuable for the early diagnosisofgastric cancer.

参考文献/References:

[1] Zheng KC,Aoki K,Li XQ,et al.Serum pepsinogen,gastrin-17 andHelicobacter pylori antibody in the residents of two cities in china with distinct mortality rates of gastric cancer[J].The Tohoku Journal of Experimental Medicine,2012,228(4):289-294.
[2] 费凤英,王金金,祝新华,等.血清胃蛋白酶原检测在胃部疾病诊断中的意义[J].检验医学,2012,27(1):57-59. Fei FY,Wang JJ,Zhu XH,et al.Clinical significance of serum pepsinogen determination in the diagnosis of various gastric diseases[J].Laboratory Medicine,2012,27(1):57-59.
[3] 张玲霞,庄 坤,张 沥,等.血清胃蛋白酶原和胃泌素-17与萎缩性胃炎关系的研究[J].陕西医学杂志,2014,43(3):279-282. Zhang LX,Zhuang K,Zhang L,et al.Significance of detection of serum pepsinogen levels and gastrin-17 levels in patients with atrophic gastritis[J].Shaanxi Medical Journal,2014,43(3):279-282.
[4] Agréus L,Kuipers EJ,Kupcinskas L,et al.Rationale in diagnosis and screening of atrophic gastritis with stomach-specific plasma biomarkers[J].Scandinavian Journal of Gastroenterology,2012,47(2):136-147.
[5] 蒋孟军,肖志坚,杨希震,等.胃蛋白酶原与胃癌的相关性研究[R].中国核情报中心,2001. Jiang MJ,Xiao ZJ,Yang XZ,et al.Correlation between pepsinogens and gastric cancer[R].China Nuclear Information Centre,2001.
[6] Mohamadkhani A,Darvish Moghaddam S,Salmanroghani H,et al.Are the serum biomarkers pepsinogen I and II good predictors for the detection of subjects with atrophic gastritis in areas that have different gastric cancer incidence?[J].Archives of Iranian Medicine(AIM),2013,16(4):208-212.
[7] Kang JM,Kim N,Yoo JY,et al.The role of serum pepsinogen and gastrin test for the detection of gastric cancer in Korea[J].Helicobacter,2008,13(2):146-156.
[8] Shikata K,Ninomiya T,Yonemoto K,et al.Optimal cutoff value of the serum pepsinogen level for prediction of gastric cancer incidence:the Hisayama Study[J].Scandinavian Journal of Gastroenterology,2012,47(6):669-675.
[9] Cao XY,Jia ZF,Jin MS,et al.Serum pepsinogen II is a better diagnosticmarker in gastric cancer[J].World J Gastroenterol,2012,18(48):7357-7361.
[10] Lomba-Viana R,Dinis-Ribeiro M,Fonseca F,et al.Serum pepsinogen test for early detection of gastric cancer in a European country[J].European Journal of Gastroenterology & Hepatology,2012,24(1):37-41.

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备注/Memo

备注/Memo:
作者简介:杨建华(1967-),女,主管技师,研究方向:临床免疫学检验研究,E-mail:13621720825@163.com。 通讯作者:林 勇,Tel:021-52888321,E-mail:linyong7007@163.com。
更新日期/Last Update: 2016-06-25