[1]邢雪梅a,李艳琴a,沈 刚a,等.抗着丝点抗体在多种疾病中的变化和意义[J].现代检验医学杂志,2016,31(03):88-91.[doi:10.3969/j.issn.1671-7414.2016.03.024]
 XING Xue-meia,LI Yan-qina,SHEN Ganga,et al.Variation and Significance of Anticentromere Antibody(ACA) in Multi-Diseases[J].Journal of Modern Laboratory Medicine,2016,31(03):88-91.[doi:10.3969/j.issn.1671-7414.2016.03.024]
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抗着丝点抗体在多种疾病中的变化和意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年03期
页码:
88-91
栏目:
论著
出版日期:
2016-06-15

文章信息/Info

Title:
Variation and Significance of Anticentromere Antibody(ACA) in Multi-Diseases
文章编号:
1671-7414(2016)03-088-04
作者:
邢雪梅1a李艳琴1a沈 刚1a张 军1a刘 蓉2李 毅1b李向东1b
1.西安交通大学医学部附属3201医院a.检验科;
b.肾病科,陕西汉中723000;
2.陕西省疾病预防控制中心慢性病管理科,西安 710054
Author(s):
XING Xue-mei1aLI Yan-qin1aSHEN Gang1aZHANG Jun1aLI Rong2 LI Yi1bLI Xiang-dong1b
1a.Department of Clinical Laboratory;
1b.Department of Nephrology,3201 Hospital Affiliated to Xi'an Jiaotong University School of Medicine,Shaanxi Hanzhong 723000,China;
2.Chronic Disease Management Department, Shaanxi Province Center for Disea
关键词:
抗着丝点抗体 着丝点蛋白B 自身免疫性疾病
分类号:
R593.2; R392.11
DOI:
10.3969/j.issn.1671-7414.2016.03.024
文献标志码:
A
摘要:
目的 研究抗着丝点抗体(anticentromere antibody,ACA)在多种疾病中的表达,为临床诊治提供指导。方法 回顾性分析129例ACA阳性患者的临床资料及实验室检测指标。结果 ①129例ACA阳性患者中女性116例,男性13例,女性ACA的血清滴度高,复合型抗体多见,与男性相比差异有统计学意义(χ2=6.28,P=0.01; χ2=6.85,P=0.003)。②118例有详细临床资料的患者中自身免疫疾病65例(55.08%),非自身免疫疾病53例(44.92%)。自身免疫疾病多见复合型、高滴度抗体,与非自身免疫疾病比较差异有统计学意义(χ2=21.97,P<0.001; χ2=11.44,P=0.001)。结论 ACA在自身免疫疾病和非自身免疫疾病中均可见到,临床表现多样,且可引起多器官受累,应引起足够重视。
Abstract:
Objective To study the expression of anticentromere antibody(ACA)on multiple diseases to help the clinical diagnosis and treatment.Methods The clinical and laboratory data of 129 cases with positive ACA were retrospectively analyzed.Results ①116 females and 13 males were found among 129 cases with positive ACA,andserology titer of ACA in female patients was higher than male and more compoundantibody were shown in female patients,which was significantly different compared with males(χ2=6.28,P=0.01; χ2=6.85,P=0.003).②Among 118 cases which had detailed clinical information,there were 65 patients suffered from autoimmune diseases(55.08%)and 53 cases suffered from non-autoimmune diseases(44.92%).Autoimmune disease cases showed more compound and high serology titer,there were significant difference between the two groups(χ2=21.97,P<0.001; χ2=11.44,P=0.001).Conclusion Though ACA was rarely found,it was shown in autoimmune and non-autoimmune diseases and can be not too severe or fetal and even lead to multi-organ failure.So it should be taken seriously.

参考文献/References:

[1] Moroi Y,Peebles C,Fritzler MJ,et al.Autoantibody to centromere(kinetochore)in scleroderma sera[J].Proc Natl Acad Sci USA,1980,77(3):1627-1631.
[2] 穆亚宏,刘小玲,任子荣,等.抗着丝粒蛋白B抗体在风湿性疾病中的临床价值[J].现代检验医学杂志,2013,28(3):152,155. Mu YH,Liu XL,Ren ZR,et al.Clinical value of antibody of anti centromere protein B in theumatic disease[J].J Mod Lab Med,2013,28(3):152,155.
[3] Miyawaki S,Asanuma H,Nishiyama S,et al.Clinical and serological heterogeneity in patients with anticentromere antibodies[J].J Rheumatol,2005,32(8):1488-1494.
[4] Earnshaw W,Bordwell B,Marino C,et al.Three human chromosomal autoantigens are recognized by sera from patients with anti-centromere antibodies[J].J Clin Invest,1986,77(2):426-430.
[5] Agarwal SK.The genetics of systemic sclerosis[J].Discov Med, 2010,10(51):134-143.
[6] Schachna L,Wigley FM,Morris S,et al.Recognition of granzyme B-generated autoantigen fragments in scleroderma patients with ischemic digital loss[J].Arthritis Rheum,2002,46(7):1873-1884.
[7] 武永康,王兰兰,彭晓东,等.抗着丝点抗体在自身免疫性疾病中的临床应用价值探讨[J].华西医学,2005.20(4):650-652. Wu YK,Wang LL,Peng XD,et al.Clinical analysis and applicable value of anticentromere antibodies in autoimmune disease[J].West China Medical Journal,2005,20(4):650-652.
[8] 夏 晴,仲人前,范列英,等.385例癌患者自身抗体检测结果分析[J].上海医学检验杂志,2001,16(1):5-7. Xia Q,Zhong RQ,Fan LY,et al.Analysis of serum autoantibodies in385 case of malignancies[J].Shanghai Journal of Medical Laboratory Sciences,2001,16(1):5-7.
[9] Vlachoyiannopouloss PG,Moutsopoulos HM.Antice-ntromere(ACA)-positiveSj(¨overo)gren's syndrome:a disease entity?[J].Clin Exp Rheumatol,2013,31(2):163-164.

备注/Memo

备注/Memo:
作者简介:邢雪梅(1973-),女,大学本科,主治医师,从事自身免疫疾病实验室诊断,E-mail:13379369191@163.com。
更新日期/Last Update: 2016-06-25