[1]李 礼,胡娟玉,于正清.IL-19在2型糖尿病患者中的 表达及与血管病变的关系[J].现代检验医学杂志,2016,31(03):92-94.[doi:10.3969/j.issn.1671-7414.2016.03.025]
　LI Li,HU Juan-yu,YU Zheng-qing.Expression of Interleukin-19 and Its Relationship with Angiopathy in 2 Diabetes Mellitus[J].Journal of Modern Laboratory Medicine,2016,31(03):92-94.[doi:10.3969/j.issn.1671-7414.2016.03.025]
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IL-19在2型糖尿病患者中的 表达及与血管病变的关系()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年03期
页码:
92-94
栏目:
论著
出版日期:
2016-06-15

文章信息/Info

Title:
Expression of Interleukin-19 and Its Relationship with Angiopathy in 2 Diabetes Mellitus
文章编号:
1671-7414(2016)03-092-03
作者:
李 礼1; 胡娟玉2; 于正清1
1.滨海县人民医院检验科,江苏滨海 224500;
2.滨海县第二人民医院检验科,江苏滨海 224541
Author(s):
LI Li1; HU Juan-yu2; YU Zheng-qing1
1.Department of Clinical Laboratory, Binhai County People's Hospital,Jiangsu Binhai 224500,China;
2.Department of Clinical Laboratory,Binhai County the Second People's Hospital,Jiangsu Binhai 224541,China
关键词:
白细胞介素-19;  2型糖尿病;  血管并发症
分类号:
R587.1; R392.11
DOI:
10.3969/j.issn.1671-7414.2016.03.025
文献标志码:
A
摘要:
目的 探讨白细胞介素-19(IL-19)水平在2型糖尿病(T2DM)患者中的表达以及与血管病变的关系。方法 选取T2DM患者120例(其中并发大血管病变32例,微血管病变52例,无血管病变36例),同期选择健康体检者50例为对照组,分别检测研究对象中IL-19,空腹血糖(FBG),胰岛素(FINS)和糖化血红蛋白(HbA1c)水平,并与对照组作比较。结果 T2DM组中IL-19水平显著高于正常对照组(41.9±11.9 pg/ml vs 16.2±8.5 pg/ml),差异有统计学意义(t=7.56,P<0.05)。T2DM并发大血管病变组和微血管病变组IL-19水平显著高于无血管病变组(t=4.57,3.26; 均P<0.05),且与病变血管数量有关。IL-19与胰岛素抵抗(HOMA-IR),HbA1c呈显著正相关(r分别为0.523和0.491,均P<0.01)。结论T2DM患者中IL-19水平显著升高,与HbA1c和HOMA-IR抵抗密切相关,并且IL-19可能参与了T2DM血管病变的发生和发展。
Abstract:
Objective To explore the expression of interleukin-19(IL-19)and to investigate the relationship between IL-19 and type 2 diabetes mellitus9(T2DM)with angiopathy.Methods IL-19,FBG,FINS and HbA1c were measured in 120 T2DM(including 32 patients with macroangiopathy,52 patients with microangiopathy and 36 without angiopathy)and 50healthy subjects,the results were compared.Results Compared with control group,the level of IL-19 in T2DM(41.9±11.9pg/ml vs 16.2±8.5pg/ml)was significantly higher than those of healthy subjects,and thedifference was signifecant(t=7.56,P<0.05).The levels of IL-19 in T2DM with macroangiopathy or microangiopathy increased significantly in comparison withthose without angiopathy(t=4.57,3.26; all P<0.05),and closely correlated with the number of angiopathy.The level of IL-19 in T2DM was significantly positive correlated with HOMA-IR and HbA1c(r=0.523 and 0.491,P<0.01).Conclusion IL-19 level was significantly increased in patients with T2DM,and was closely related with HbA1c,insulin resistance,IL-19 may play acertain role in the pathogenesis of in T2DM with vascularcomplications.

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备注/Memo

备注/Memo:
基金项目:南京医科大学江苏康达医药卫生发展研究院科研项目(NYKDKJ2015020); 滨海县人民医院科研项目(BYKJ2016)。 作者简介:李 礼(1977-),男,副主任检验师,主要从事临床生化检验诊断,E-mail:lili5898@126.com。
更新日期/Last Update: 2016-06-25