[1]李小侠a,解 娟a,詹 颉a,等.围产期胎膜早破与生殖道病原菌感染的分析[J].现代检验医学杂志,2016,31(04):90-92.[doi:10.3969/j.issn.16717-414.2016.04.024]
　LI Xiao-xiaa,XIE Juana,ZHAN Jiea,et al.Analysis of Perinatal Premature Rupture of Membranes and Reproductive Tract Pathogen Infection[J].Journal of Modern Laboratory Medicine,2016,31(04):90-92.[doi:10.3969/j.issn.16717-414.2016.04.024]
点击复制

围产期胎膜早破与生殖道病原菌感染的分析()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年04期
页码:
90-92
栏目:
论著
出版日期:
2016-08-10

文章信息/Info

Title:
Analysis of Perinatal Premature Rupture of Membranes and Reproductive Tract Pathogen Infection
文章编号:
1671-7414(2016)04-090-03
作者:
李小侠a; 解 娟a; 詹 颉a; 马 娟a; 孙 杨b; 苍金荣a; 秦 利c; 张利侠a
陕西省人民医院a.检验科;
b.统计室;
c.产科,西安 710068
Author(s):
LI Xiao-xiaa; XIE Juana; ZHAN Jiea; MA Juana; SUN Yangb; CANG Jin-ronga; QIN Lic;  ZHANG Li-xiaa
a.Department of Clinical Laboratory;
b.Department of Data Analysis;
c.Department of Gynaecology,Shaanxi Provincial People's Hospital,Xi'an 710068,China
关键词:
胎膜早破;  病原菌感染;  分析
分类号:
R714.433; R446.5
DOI:
10.3969/j.issn.16717-414.2016.04.024
文献标志码:
A
摘要:
目的 分析围产期发生胎膜早破与生殖道病原菌感染的关系。方法 依照病例定义选择2011年6月～2012年5月陕西省人民医院产科的正常孕妇112例和胎膜早破的孕妇108例,采集孕妇的阴道分泌物和宫颈分泌物用定量PCR检测解脲支原体(ureaplasma urealyticum,UU)、沙眼衣原体(chlamydia trachomatis,CT)、B族链球菌(group B streptococcus,GBS)、白色念珠菌(candida albicans,C.albicans)、淋病奈瑟菌(neisseria gonorrhoeae,NG)、单疱病毒Ⅰ(herps simple virusⅠ,HSV-Ⅰ)和单疱病毒Ⅱ(herps simple virusⅡ,HSV-Ⅱ)共7种病原菌,对研究数据用卡方检验和Fisher判别分析病原菌感染与胎膜早破的关系。结果 7种病原菌中UU,GBS和CT的感染在正常孕产妇组和胎膜早破孕产妇组之间的差异有统计学意义(χ2=3.644～6.093,P<0.05),而C.albicans,NG,HSV-Ⅰ,HSV-Ⅱ的感染在二组间差异无统计学意义(χ2=0.000～0.046,P> 0.05)。同时阴道分泌物病原菌定量检测:UU≥105 copy/ml,CT≥103 copy/ml和GBS≥103 copy/ml的含量在正常孕产妇和胎膜早破孕产妇之间的差异有统计学意义(χ2=0.278～7.015,P<0.05)。采用Fisher判别分析病原菌的分类正确性,对UU按照<103 copy/ml,103～104 copy/ml,≥105 copy/ml分为三段; GBS按照<103 copy/ml和≥103 copy/ml分为两段; CT按照<103 copy/ml和≥103 copy/ml分为两段作散点图,投影显示UU,GBS和CT感染分类区分明显,说明病原菌感染的数量与胎膜早破的发生是密切相关的,为临床提供了判断感染的依据。结论 围产期发生胎膜早破与生殖道病原菌感染的数量有关,临床应结合病原菌的感染数量来评估其与胎膜早破发生的相关性。
Abstract:
Objective To analysis of the perinatal premature rupture of membranes occurred relations with genital tract pathogen infection.Methods According to the case definition,selected 112 cases of normalpregnant women and 108 cases of pregnant women with premature rupture of membranes in Shaanxi Provincial People's Hospital from June 2011 to May 2012.Collected vaginal and cervical secretions of the pregnant women,and detected 7 kinds of pathogen Ureaplasma Mycoplasma,Chlamydia trachomatis,group B Streptococcus bacteria,Candida albicans,Neisseria gonorrhea,Herps simple virus Ⅰ and Herps simple virus Ⅱ totally with quantitative PCR method.To the research data,discriminated and analyzed the relationship between pathogen infection and premature rupure of membranes.Results Seven kinds of pathogenic bacteria in UU,GBS and CT infection in the normal maternal premature rupture of membranes and maternal group the difference was statistically significant between(χ2=3.644～6.093,P<0.05),while C.albicans.NG,HSV-Ⅰ,HSV-Ⅱ no statistical difference between two groups(χ2=0.000～0.046,P> 0.05).And vaginal pathogen quantitative detection:UU≥105 copy/ml,CT≥103 copy/ml,GBS≥103 copy/ml in premature rupture of membranes and maternal between the difference was statistically significant(χ2=0.278～7.015,P<0.05).By the Fisher discriminant analysis pathogen classification accuracy,the UU according to UU<103 copy/ml,103～104 copy/ml,≥105 copy/ml was divided into three sections; GBS according to <103 copy/ml and ≥103 copy/ml was divided into two sections; CT according to <103 copy/ml and ≥103 copy/ml was divided into two segments to make a scatter diagram,projection display UU,GBS and CT classification to distinguish between apparent infection,the number of pathogen infection and is closely related to the occurrence of premature rupture of membranes,for clinical provides the basis of infection.Conclusion Perinatal premature rupture of membranes occurred related to the number of genital tract pathogen infection,clinical should be combined with pathogen infection number to assess their correlation with premature rupture of membranes.

参考文献/References:

[1] 张利侠,吴桂清,秦 利,等.围产期发生胎膜早破的多因素分析[J].现代检验医学杂志,2013,28(6):142-143,146-147. Zhang LX,Wu GQ,Qin L,et al.Analysis multiple factors to perinatal premature rupture of membranes occurred[J].Journal of Mordern Laboratory Medicine,2013,28(6):142-143,146-147.
[2] Al Riyami N,Al-Ruheili I,Al-Shezaw F,et al.Extreme preterm premature rupture of membranes:risk factors and feto maternal outcomes[J].Oman Medical Journal,2013,28(2):108-111.
[3] 张 赟,李 娅,郭旭昌,等.胎膜早破孕妇生殖道感染病原菌的分布及耐药性分析[J].现代检验医学杂志,2015,30(3):98-100. Zhang Y,Li Y,Guo XC,et al.Distribution and drug resistance of genital tract pathogenic bacteria in pregnant women with premature repture of membrane[J].Journal of Mordern Laboratory Medicine,2015,30(3):98-100.
[4] 秦 利,李晓侠,张利侠,等.胎膜早破阴道分泌物异常对母婴结局的影响[J].陕西医学杂志,2013,42(9):1220-1221. Qin L,Li XX,Zhang LX,et al.The influence of the vaginal sectretions on PEOM and the maternal infant outcome[J].Shaanxi Medical Journal,2013,42(9):1220-1221.
[5] 李亚梅,张利侠,秦 利,等.围产期孕妇B族链球菌的感染和耐药性检测及对妊娠结局的影响[J].现代 检验医学杂志,2013,28(1):87-89. Li YM,Zhang LX,Qin L,et al.Detection of group B streptococusand analysis of drug resistance in perinatal pregnant women and the influence of the pregnancy outcome[J].Journal of Modern Laboratory Medicine,2013,28(1):87-89.
[6] Casanueva E,Ripoll C,Meza-Camacho C,et al.Possible interplay betweenvitamin C deficiency and prolactin in pregnant women with premature rupture ofmembranes:facts and hypothesis[J].Medical Hypotheses,2005,64(2):241-247.
[7] Lee SM,Park JW,Kim BJ,et al.Acute histologic chorioamnionitis is a riskfactor for adverse neonatal outcome in late preterm birth after preterm premature rupture of membranes[J].PloS Oone,2013,8(12):e79941.
[8] 李武菊.未足月胎膜早破60例相关因素分析[J].陕西医学杂志,2011,40(6):742-743. Li WJ.Premature rupture of membranes before term 60 cases related factors analysis[J].Shaanxi Medical Journal,2011,40(6):742-743.
[9] 刘媛媛,单瑞芹.胎膜早破病因的研究进展[J].中国妇幼保健杂志,2008,23(13):1888-1889. Liu YY,Shan RQ.The research progress of cause premature rupture ofmembranes[J].Maternal and Child Health Care of China,2008,23(13):1888-1889.

相似文献/References:

[1]张 赟,李 娅,郭旭昌,等.胎膜早破孕妇生殖道感染病原菌的分布及耐药性分析[J].现代检验医学杂志,2015,30(03):98.[doi:10.3969/j.issn.1671-7414.2015.03.028]
　ZHANG Yun,LI Ya,GUO Xu-chang,et al.Distribution and Drug Resistance of Genital Tract Pathogenic Bacteria in Pregnant Women with Premature Rupture of Membrane[J].Journal of Modern Laboratory Medicine,2015,30(04):98.[doi:10.3969/j.issn.1671-7414.2015.03.028]
[2]吴 慧a,韩文龙b,柏 蕾,等.胎膜早破产妇血清SFRP5，TIMP-1 和HMGB1 水平与并发组织学绒毛膜羊膜炎的相关性研究[J].现代检验医学杂志,2022,37(05):112.[doi:10.3969/j.issn.1671-7414.2022.05.022]
　WU Huia,HAN Wen-longb,BO Lei,et al.Correlation of Serum SFRP5, TIMP-1 and HMGB1 Levels with Histological Chorioamnitis in Pregnant Women with Premature Rupture of Membranes[J].Journal of Modern Laboratory Medicine,2022,37(04):112.[doi:10.3969/j.issn.1671-7414.2022.05.022]
[3]杨 柳,付 欣,张小飞.胎膜早破孕妇生殖道无乳链球菌血清型分型和耐药基因分析[J].现代检验医学杂志,2023,38(03):123.[doi:10.3969/j.issn.1671-7414.2023.03.022]
　YANG Liu,FU Xin,ZHANG Xiao-fei.Serotyping and Resistance Gene Analysis of Reproductive Streptococcus Agalactiae in Women with Premature Rupture of Membranes[J].Journal of Modern Laboratory Medicine,2023,38(04):123.[doi:10.3969/j.issn.1671-7414.2023.03.022]
[4]宋 园,屈小红,李维玲,等.胎膜早破并发绒毛膜羊膜炎患者胎盘组织中组蛋白H3K4me3，H3K27me3及修饰酶表达的临床价值研究[J].现代检验医学杂志,2025,40(02):174.[doi:10.3969/j.issn.1671-7414.2025.02.033]
　SONG Yuan,QU Xiaohong,LI Weiling,et al.Clinical Value of Histone H3K4me3, H3K27me3 and Modifying Enzyme Expression in Placental Tissue of Patients with Premature Rupture of Fetal Membrane Complicated with Chorioamnionitis[J].Journal of Modern Laboratory Medicine,2025,40(04):174.[doi:10.3969/j.issn.1671-7414.2025.02.033]

备注/Memo

备注/Memo:
基金项目:陕西省科技厅自然基金项目(2014JM-8200)。
作者简介:李小侠(1976-),女,大学本科,主管技师,从事临床检验工作,E-mail:lixiaoxiamrr@163.com。
通讯作者:张利侠(1970-),女,在读博士,研究方向:临床感染与诊断治疗。
更新日期/Last Update: 2016-08-10