[1]白 茹,仇秋明.凋亡促进分子TFAR19与子宫肌瘤关系的研究[J].现代检验医学杂志,2016,31(05):94-96.[doi:10.3969/j.issn.1671-7414.2016.05.025]
　BAI Ru,QIU Qiu-ming.Relationship between Apoptosis Promoting Effector Molecule TFAR19 and Uterine Myoma[J].Journal of Modern Laboratory Medicine,2016,31(05):94-96.[doi:10.3969/j.issn.1671-7414.2016.05.025]
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凋亡促进分子TFAR19与子宫肌瘤关系的研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年05期
页码:
94-96
栏目:
论著
出版日期:
2016-10-21

文章信息/Info

Title:
Relationship between Apoptosis Promoting Effector Molecule TFAR19 and Uterine Myoma
文章编号:
1671-7414(2016)05-094-03
作者:
白 茹; 仇秋明
北京市怀柔区妇幼保健院,北京 101400
Author(s):
BAI Ru; QIU Qiu-ming
Maternal and Child Health Hospital of Beijing Huairou, Beijing101400,China
关键词:
子宫肌瘤;  TFAR19;  细胞凋亡
分类号:
R711.74; R446
DOI:
10.3969/j.issn.1671-7414.2016.05.025
文献标志码:
A
摘要:
目的 检测子宫肌瘤患者血清TFAR19活性。方法随机选择北京市怀柔区妇幼保健院妇产科住院接受手术的子宫肌瘤患者45例,其中6 cm≤单个最大肌瘤直径≤10㎝的患者29例(A组)、单个最大肌瘤直径>10 cm的患者16例(B组),同时随机选取育龄期健康体检者25例作为对照组(C组),A,B组于入院当晚采集外周静脉血,C组于体检当天采集外周静脉血,采用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)检测子宫肌瘤患者血清中TFAR19活性。结果 A组、B组、C组TFAR19活性分别为25.32±1.93,14.41±2.28,34.79±4.65活性单位; 各组间TFAR19活性差异有统计学意义(F=7.93,P=0.01); 与C组相比,B组(q=5.606,P<0.001)、A组(q=3.055,P=0.034)间TFAR19活性差异具有统计学意义; A组,B组之间TFAR19活性差异有统计学意义(q=3.086,P=0.033)。各组之间年龄差异无统计学意义(F=2.086,P=0.132)。结论 子宫肌瘤患者血清TFAR19表达下调抑制了细胞凋亡过程,参与了子宫肌瘤的发生,并且与肌瘤的大小相关,肌瘤直径越大,TFAR19表达越低。
Abstract:
Objective To examine serum TFAR19 activity in uterine myoma patients.Methods 45 of operation patients with uterine myoma in Beijing Huairou Maternal and Child Health Hospital were recruited.Among them,diameter of maximal myoma from 6 to 10 centineters were 29(group A),diameter of maximal myoma more than 10 centineters were 16(group B).In addition,25 unrelated healthy women of childbearing age from physical examination center were enrolled as controls(group C),all of the peripheral venous blood was collected after admission.Enzyme-linked immunosorbent assay(ELISA)was used to examine serum TFAR19 activity in uterine myoma patients.Results The activity of TFAR19 in group A,group B and group C were 25.32±1.93,14.41±2.28 and 34.79±4.65 respectively.The TFAR19 activityin each group was statistically significant difference(F=7.93,P=0.01).Compared with group C,the TFAR19 activity in group B(q=5.606,P<0.001),group A(q=3.055,P=0.034)was statistically significant difference.The TFAR19 activity in uterine myoma patients subgroups(group A,group B)was statistically significant difference(q=3.086,P=0.033).Age between each groupswas not statistically significant difference(F=2.086,P=0.132).Conclusion The decrease of TFAR19 can inhibit apoptosis.Participating the occurrence of uterine myoma,it is connected with diameter of myoma.The larger diameter of myoma,the lower TFAR19 activity of examination will be.

参考文献/References:

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备注/Memo

备注/Memo:

作者简介:白 茹(1981-),女,本科,主治医师,研究方向:妇科,Tel:13901018552,E-mail:BaiRu608@163.com。
更新日期/Last Update: 2016-10-30