[1]江梅,狄长春,郭磊,等.促肾上腺皮质激素,皮质醇节律变化与原发性高血压的关系探讨[J].现代检验医学杂志,2016,31(06):13-16.[doi:10.3969/j.issn.1671-7414.2016.06.004]
　JIANG Mei,DI Chang-chun,GUO Lei,et al.Relationship Receach on Adrenocorticotropic Hormone,Cortisol of Patients with Essential Hypertension about Rhythmic Variation[J].Journal of Modern Laboratory Medicine,2016,31(06):13-16.[doi:10.3969/j.issn.1671-7414.2016.06.004]
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促肾上腺皮质激素,皮质醇节律变化与原发性高血压的关系探讨()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年06期
页码:
13-16
栏目:
论著
出版日期:
2016-12-20

文章信息/Info

Title:
Relationship Receach on Adrenocorticotropic Hormone,Cortisol of Patients with Essential Hypertension about Rhythmic Variation
作者:
江梅; 狄长春; 郭磊; 申黎阳; 段红兴
焦作市第二人民医院,河南理工大学第一附属医院,河南焦作 454001
Author(s):
JIANG Mei; DI Chang-chun; GUO Lei; SHEN Li-yang; DUANHong-xing
the Second People's Hospital of Jiaozuo,the First Affiliated Hospital of Henan Polytechnic University,Henan Jiaozuo 454001,China
关键词:
促肾上腺皮质激素;  皮质醇;  单纯原发性高血压;  原发性高血压伴冠心病;  原发性高血压并发缺血性脑卒中
分类号:
R544.11; R392.11
DOI:
10.3969/j.issn.1671-7414.2016.06.004
文献标志码:
A
摘要:
目的 探讨不同时间点血浆促肾上腺皮质激素(ACTH)与皮质醇(Cor)节律变化与原发性高血压的关系。方法 选取焦作市第二人民医院2012年7月～2014年3月期间住院及门诊原发性高血压患者90例并进一步经冠状动脉造影术和头颅磁共振成像(MRI)或计算机断层扫描(CT)分为3组:(B组)单纯原发性高血压组(42例),(C组)原发性高血压伴冠心病组(17例)和(D组)原发性高血压并发缺血性脑卒中组(31例)及(A组)健康查体者60例作为对照组。均采用放射免疫法进行24h内血浆ACTH和血清Cor 8:00,16:00,24:00不同时点检测,结果进行统计学分析。结果 血浆ACTH 8:00,16:00,24:00水平,D组(18.23±6.36,11.29±7.35,5.69±3.02 pg/ml)低于A组(24.83±8.98,15.56±8.56,9.45±2.22 pg/ml),差异有统计学显著性意义(t=4.56,P=0.012)。其余B组,C组与A组血浆ACTH 8:00,16:00,24:00比较差异无统计学意义(t=1.021～1.766,P值均>0.05),血清Cor 8:00,16:00,24:00水平,D组(326.53±56.3,176.9±59.6,165.2±42.5 ng/ml)和C组(310.03±45.01,167.6±55.0,161.9±49.6 ng/ml)均较B组(227.6±65.2,127.9±29.7,121.6±15.4 ng/ml)的表达为高,差异有统计学显著性意义(t=3.26,4.62,均P=0.016); 三者与A组(127.6±21.3,87.9±18.5,27.9±6.5 ng/ml)比较差异均有统计学显著性意义(t=6.39,6.89和7.23,P=0.001)。结论原发性高血压患者尤其有缺血性脑卒中时血浆ACTH水平更低。单纯原发性高血压患者血清Cor水平升高; 当并发冠心病或缺血性脑卒中时,血清Cor水平则更高。
Abstract:
Objective To explore rhythmic variation about the relationship of adrenocorticotropic hormone(ACTH)and cortisol(Cor)with theessential hypertension at different time.Methods Chose90 cases of patients in hospital and outpatient who visited the Second People'sHospital of Jiaozuo between July 2012 and March 2014 with essential hypertension(EH)and furthere by coranory angiograph and head MRI or CT,they was dividedinto three groups:B groups(n=42),C groups(n=17)and D group(n=31).60 cases of healthy physical examination was as a control group.Detected plasma ACTH and serum Cor at 8:00,16:00,24:00 o'clock with the radioimmunoassay.Results The plasma ACTH at 8:00,16:00,24:00 o'clock of D group(18.23±6.36,11.29±7.35,5.69±3.02 pg/ml)were lower than A group(24.83±8.98,15.56±8.56,9.45±2.22 pg/ml)with significant diffences(t=4.56,P=0.012).and other groups B,C,A showed no significant change(t=1.566,P>0.05).Serum cortisol levels,D group(326.53±56.3,176.9±59.6,165.2±42.5 ng/ml)and B groups(310.03±45.01,167.6±55.0,161.9±49.6 ng/ml)were higher than C groups(227.6±65.2,127.9±29.7,121.6±15.4 ng/ml)with significant difference(t=3.26,4.62,P=0.016).Three groups compared with the B group(127.6±21.3,87.9±18.5,27.9±6.5 ng/ml)had very significant difference(t=6.39,6.89 and 7.23,P=0.001).Conclusion ACTH levels were lower with cerebral ischemic stroke.There were elevated Cor in serum of pureessentian hypertension patients,with amalgamative coronary heart disease(CHD)or ischemic stroke,serum cortisol levels were higher.

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备注/Memo

备注/Memo:
作者简介:江 梅(1973-),女,硕士研究生,副主任检验技师,研究方向:细胞生物学和分子生物学,Tel:13069453885。
更新日期/Last Update: 2016-12-20