[1]金永久,李明,曹晓玲,等.基于ICP-MS探讨血液透析患者与正常人全血中矿物元素含量的差异[J].现代检验医学杂志,2016,31(06):112-114，117.[doi:10.3969/j.issn.1671-7414.2016.06.032]
　JIN Yong-jiu,LI Ming,CAO Xiao-ling,et al.Study on Differences in Mineral Elements in Blood between Post-dialysis Patients and Healthy Human Beings[J].Journal of Modern Laboratory Medicine,2016,31(06):112-114，117.[doi:10.3969/j.issn.1671-7414.2016.06.032]
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基于ICP-MS探讨血液透析患者与正常人全血中矿物元素含量的差异()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年06期
页码:
112-114，117
栏目:
研究简报·实验技术
出版日期:
2016-12-20

文章信息/Info

Title:
Study on Differences in Mineral Elements in Blood between Post-dialysis Patients and Healthy Human Beings
作者:
金永久1; 李明1; 曹晓玲1; 张悦2; 黄伟华1
1.南昌市疾病预防控制中心,南昌 330038; 2.南昌市第二医院,南昌330003
Author(s):
JIN Yong-jiu1; LI Ming1; CAO Xiao-ling1; ZHANGYue2; HUAMG Wei-hua1
1.Nanchang Center for Disease Control and Prevention,Nanchang330038,China; 2.the Second Hospital of Nanchang,Nanchang 330003,China
关键词:
血液透析;  全血;  矿物元素;  电感耦合等离子质谱(ICP-MS)
分类号:
R459.5; R446.112
DOI:
10.3969/j.issn.1671-7414.2016.06.032
文献标志码:
A
摘要:
目的 比较血液透析患者与健康人群全血中矿物元素含量,为血液透析病人合理治疗和保健提供依据。方法 以维持血液透析治疗1年以上的33例患者为实验组,和实验组年龄、性别相匹配的33例健康人为对照组,分别采集其静脉血5 ml,使用电感耦合等离子质谱(ICP-MS)分析法测定静脉血中部分矿物元素含量,并按照独立样本t检验,对结果进行比较。结果 全血中铁、钙、锌、铜、硒和铅平均含量,实验组分别为219.01,50.02,3.91,0.70,0.077和0.085 mg/L; 对照组分别为426.59,73.43,4.73,0.80,0.18和0.071 mg/L。按成组样本t检验,全血中铁、钙、锌、铜和硒含量实验组低于对照组(t=-18.3～3.84,P值均<0.01); 而血铅浓度实验组高于对照组(t=2.06,P< 0.05)。结论 血液透析患者钙、铁、铜、锌和硒等矿物元素含量低于健康人群,为维持机体正常机能应适当补充,同时应监测血铅含量,以防铅中毒。
Abstract:
Objective To investigate difference in mineralelements in blood between post-dialysis patients and healthy human beings in order to provide the basis for the treatment and care of dialysis patients.Methods 33 patients as experimental group who were treated with hemodialysis for more than 1 year and 33 healthy human beings as control groupwho were matched with the experimental group by age and gender were selected,then samples of blood were respectively collected about 5ml and the contents of mineral elements in blood samples were detected by ICP-MS and the results were applied independent-Samples t test to perform statistical analysis for the experimental group and the control group.Results For the experimental group,Iron,calcium,zinc,copper,selenium average concentration were219.01,50.02,3.91,0.70 and 0.077 mg/L respectively and were significantly lower than the control group with 426.59,73.43,4.73/L,0.80 and 0.18 mg/L,respectively(t=-18.3～3.84,P<0.01).However,lead average concentration(0.085 mg/L)of the experimental group was higher than that of the control group(0.071 mg/L,t=2.06,P< 0.05).Conclusion Long-term dialysis patients should have appropriate supplement with calcium,iron,copper,zinc,selenium and other mineral elements in order to maintain the body's normal function.And furthermore,there was a risk of poisoning caused by transient sharp increase of blood lead contents.

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备注/Memo

备注/Memo:
基金项目:南昌市科技局计划项目(立项文号158,项目编号38)。 作者简介:金永久(1980-),男,硕士,主管技师,研究方向:卫生理化分析,E-mail:yongjiu jin@163.com。 通讯作者:黄伟华,女,主任技师,E-mail:huangweihua 1984@163.com。
更新日期/Last Update: 2016-12-20