[1]宋文炜.血浆D-二聚体检测对甲状腺癌患者的临床意义[J].现代检验医学杂志,2016,31(06):138-140.[doi:10.3969/j.issn.1671-7414.2016.06.041]
　SONG Wen-wei.Clinical Significance of Plasma D-dimer Testing in Patients with Thyroid Cancer[J].Journal of Modern Laboratory Medicine,2016,31(06):138-140.[doi:10.3969/j.issn.1671-7414.2016.06.041]
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血浆D-二聚体检测对甲状腺癌患者的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年06期
页码:
138-140
栏目:
检验与临床
出版日期:
2016-12-20

文章信息/Info

Title:
Clinical Significance of Plasma D-dimer Testing in Patients with Thyroid Cancer
作者:
宋文炜
徐州矿物集团总医院检验科,江苏徐州 221000
Author(s):
SONG Wen-wei
Department of Clinical Laboratory, Xuzhou Mining Group General Hospital,Jiangsu Xuzhou 221000,China
关键词:
D-二聚体;  甲状腺癌;  临床分期
分类号:
R736.1; R730.43
DOI:
10.3969/j.issn.1671-7414.2016.06.041
文献标志码:
A
摘要:
目的 观察血浆D-二聚体检测在甲状腺癌患者手术前后及分期的变化,探讨其对甲状腺癌患者的临床意义。方法 选择60例甲状腺癌患者,同期甲状腺良性病变患者50例,健康体检者52例,观察各组空腹血浆D-二聚体水平,并进行比较; 同时,对甲状腺癌患者术后血浆D-二聚体水平进行监测。结果 甲状腺癌患者血浆D-二聚体水平(2.01±0.75 mg/L)明显高于良性组(0.63±0.31 mg/L)及健康体检组(0.28±0.12 mg/L),差异具有统计学意义(t=11.72,11.06,均P<0.000 1); 血浆D-二聚体水平与甲状腺癌恶性程度相关,分期Ⅲ～Ⅳ期患者血浆D-二聚体水平明显高于l～Ⅱ期患者(t=9.83,P<0.05); 在术后一周甲状腺癌患者D-二聚体水平明显下降。结论 D-二聚体水平在甲状腺癌患者手术前后有明显变化,且与临床分期有关,可作为甲状腺癌患者治疗评价及疾病监测、预后的指标,具有临床应用价值。
Abstract:
Objective To observe the levels of plasma D-dimer in patients with thyroid cancer before and after surgery,and explore itsclinical significance.Methods 60patients with thyroid cancer,50 patients with thyroid benign lesions and 52 healthy controls were chosen in the study.D-dimer levels in different groups weretested.At the same time,for patients with thyroid carcinoma,the postoperative levels of plasma D-dimer were monitored.Results Level of plasma D-dimer in patients with thyroid cancer(2.01±0.75 mg/L)was significantly higher than those in thyroid benign lesions group(0.63±0.31 mg/L)and healthy control(0.28±0.12 mg/L)(t=11.72,11.06,all P<0.000 1).Plasma D-dimer levels were corelated with malignant degrees of thyroid carcinoma,patients in stage Ⅲ-Ⅳ had a higher level of plasma D-dimer than I-Ⅱperiod patients(t=9.83,P<0.05).The postoperative level of D-dimer in patients with thyroid cancer were significantly decreased.Conclusion D-dimer levels were obviously changed in thyroid cancer patients before and after surgery,and was corelated with clinical stages.Thus,it could be used as an evaluation index of treatment outcome and a prognostic factor for patients with thyroid cancer.

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备注/Memo

备注/Memo:
作者简介:宋文炜(1974-),男,学士学位,副主任技师,专业:临床检验,E-mail:37580753@qq.com。
更新日期/Last Update: 2016-12-20