[1]王 冰,朱月蓉,何玉杰,等.血清结合珠蛋白在宫颈癌诊断中的应用研究[J].现代检验医学杂志,2017,32(01):106-108.[doi:10.3969/j.issn.1671-7414.2017.01.029]
　WANG Bing,ZHU Yue-rong,HE Yu-jie,et al.Application of Haptoglobin in Cervical Cancer Diagnosis[J].Journal of Modern Laboratory Medicine,2017,32(01):106-108.[doi:10.3969/j.issn.1671-7414.2017.01.029]
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血清结合珠蛋白在宫颈癌诊断中的应用研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年01期
页码:
106-108
栏目:
论著
出版日期:
2017-01-25

文章信息/Info

Title:
Application of Haptoglobin in Cervical Cancer Diagnosis
文章编号:
1671-7414(2017)01-106-03
作者:
王 冰; 朱月蓉; 何玉杰; 邱 红
解放军第81医院检验科,南京 210002
Author(s):
WANG Bing; ZHU Yue-rong; HE Yu-jie; QIU Hong
Department of Clinical Laboratory,PLA 81 Hospital,Nanjing 210002,China
关键词:
结合珠蛋白;  宫颈癌;  肿瘤标志物
分类号:
R737.33; R730.43
DOI:
10.3969/j.issn.1671-7414.2017.01.029
文献标志码:
A
摘要:
目的 探讨血清结合珠蛋白(haptoglobin,Hp)的含量在宫颈癌诊断中的临床意义。方法 收集45例宫颈癌患者、37例宫颈良性疾病患者和41例女性健康对照血清,采用免疫比浊法测定血清中Hp的含量,化学发光法测定SCC和CA125的含量,各组间比较采用t检验。结果 宫颈癌患者Hp平均含量为1.69 g/L,与宫颈良性疾病患者Hp含量(0.90 g/L)和健康人血清Hp含量(0.69 g/L)相比差异均有统计学显著性意义(t值分别为3.26和4.42,P值分别为0.001和0.000)。在宫颈癌早期血清Hp含量即明显升高。Hp,SCC和CA125诊断宫颈癌的ROC曲线下面积分别为0.853,0.751和0.494。Hp,SCC和CA125诊断宫颈癌的灵敏度分别为87%,49%和29%,特异度分别为68%,88%和83%,三者联合检测的灵敏度为93%。结论 血清结合珠蛋白在宫颈癌诊断中具有一定的临床价值,是潜在的血清肿瘤标志物。
Abstract:
Objective To investigate the clinical value ofserum Haptoglobin(Hp)levels in cervical cancer patients.MethodsSerum Hp(with immunoturbidimetry method),SCC,CA125(with electrochemiluminescence immunoassay method)level were detected in 45 patients with cervical cancer,37patients with cervical benign disease and 41 female healthy controls.Results Serum Hp level of cervical cancer patients(mean:1.69 g/L)was strongly higher than the level of cervical benign diseasepatients(mean:0.90g/L)and healthy subjects(mean:0.69 g/L)(t=3.26,4.42,P=0.001,0.000,respectively).Hp level rises highly in the early stage of cervical cancer.The area under receiver operating characteristic curve(AUCROC)of Hp was 0.853 which was higher than SCC(AUC=0.751)andCA125(AUC=0.494).The sensitivity of Hp,SCC,and CA125 were 87%,49% and 29% respectively.The specificity of Hp,SCC and CA125 were 68%,88% and 83% respectively.Three tumor markers combined together could produce a positive detection rate of93%.Conclusion The detection of Hp has clinic significance on diagnosis of cervical cancer,and it's possible to become a serum tumor marker.

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备注/Memo

备注/Memo:
作者简介:王 冰(1980-),女,博士,主管技师,主要从事临床生化检验工作,Tel:025-80864159,E-mail:wb800225@163.com。
通讯作者:邱 红,女,硕士,主任技师,主要从事临床生化检验工作,E-mail:mapleqh@126.com。
更新日期/Last Update: 2017-01-20