[1]曹小燕,付 坤,叶 青,等.SLE患者的血清载脂蛋白M表达水平与疾病活动相关性研究[J].现代检验医学杂志,2017,32(01):138-140,143.[doi:10.3969/j.issn.1671-7414.2017.01.038]
　CAO Xiao-yan,FU Kun,YE Qing,et al.Correlation between Serum Apolipoprotein M Expression and Disease Activity in Patients with SLE[J].Journal of Modern Laboratory Medicine,2017,32(01):138-140,143.[doi:10.3969/j.issn.1671-7414.2017.01.038]
点击复制

SLE患者的血清载脂蛋白M表达水平与疾病活动相关性研究()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年01期
页码:
138-140,143
栏目:
检验与临床
出版日期:
2017-01-25

文章信息/Info

Title:
Correlation between Serum Apolipoprotein M Expression and Disease Activity in Patients with SLE
文章编号:
1671-7414(2017)01-138-04
作者:
曹小燕; 付 坤; 叶 青; 李凤霞
十堰市人民医院/湖北医药学院附属人民医院风湿免疫科,湖北十堰 442000
Author(s):
CAO Xiao-yan; FU Kun; YE Qing; LI Feng-xia
Department of Rheumatology and Immunology,Renmin Hospital of Shiyan City,Affiliated Hospital of Hubei Medical College,Hubei Shiyan 442000,China
关键词:
载脂蛋白M;  载脂蛋白;  系统性红斑狼疮;  活动度
分类号:
R593.241; R446.11
DOI:
10.3969/j.issn.1671-7414.2017.01.038
文献标志码:
A
摘要:
目的 研究系统性红斑狼疮(systemic lupus erythematosus,SLE)患者中血清载脂蛋白M的表达水平及其疾病活动度指数。方法 选取十堰市人民医院2013年1月～2015年12月门诊确诊为系统性红斑狼疮患者65例,另选该院女性职工20人设为对照组。检测血脂,Apo,CRP与ESR的含量,对比Apo M与Apo A1,Apo B的表达水平及疾病活动度。结果 活动组和缓解组的Apo A1,HDL,TC和Apo M均低于对照组,差异有统计学意义(P＜0.01); 活动组和缓解组的LDL和ApoB高于对照组,差异有统计学意义(P＜0.01); 活动组和缓解组的TG高于对照组,但差异无统计学意义(F=0.061,P=0.937); Apo A1与总胆固醇、高密度脂蛋白、滑蛋白呈正相关(P＜0.05),与ESR,24 h尿蛋白定量呈明显负相关(P＜0.05); Apo B与三酰甘油、总胆固醇、低密度脂蛋白呈明显正相关(P＜0.05); Apo M与三酰甘油、总胆固醇、低密度脂蛋白、高密度脂蛋白、滑蛋白呈明显正相关(P＜0.05),与ESR,抗ds-DNA抗体呈负相关。结论 SLE患者中Apo M表达水平明显降低,与三酰甘油、总胆固醇、低密度脂蛋白、高密度脂蛋白、滑蛋白呈明显正相关,与ESR,抗ds-DNA抗体呈负相关,疾病活动度指数较大。
Abstract:
Objective To study the level of serum apolipoprotein M and its disease activity index in patients with SLE.Methods65 cases of systemic lupus erythematosus patients in Shiyan City Renmin Hospital from January 2013 to December 2015 were selected.In addition,female workers 20 people as control group.Tested the level of serum lipids,Apo,CRP and ESR.Compared the expression level with Apo M and Apo A1,and Apo B and the degree of disease activity.Results Activity group andApo A1,HDL,TC,remission group,Apo and M were lower than the control group,the difference was statistically significant(P＜0.01).Active group,remission group LDL and Apo B was higher than the control group,and the difference was statistically significant(P＜0.01).Active group and remission group TG was higher than the control group,but no significant significant differences(F=0.061,P=0.937).Apo A1 and total cholesterol,high density lipoprotein,smooth protein was positively correlated(P＜0.05),and ESR was negatively correlated with the 24h urinary protein(P＜0.05).Apo B was positively correlated with triglyceride,total cholesterol,and low density lipoprotein(P＜0.05).Apo M and triglyceride,total cholesterol,low density lipoprotein cholesterol,high density lipoprotein,albumin was significantly positively correlated,and ESR was negatively correlated with anti ds-DNA antibody(P＜0.05).Conclusion The level of Apo M was significantly lower in SLE patients which showed a significant positive correlation with triglyceride,total cholesterol,low density lipoprotein,high density lipoprotein and albumin.And showed a negatively correlated with anti ds-DNA antibody and ESR.Disease activity index of Apo M is larger.

参考文献/References:

[1] Jeyakkumar P,Zhang L,Avula SR,et al.Design,synthesis and biological evaluation of berberine-benzimidazole hybrids as new type of potentially DNA-targeting antimicrobial agents[J].Eur J Med Chem,2016,122:205-215.
[2] Ye WL,Tang N,Wen YB,et al.Underlying renal insufficiency:the pivotalrisk factor for Pneumocystis jirovecii pneumonia in immunosuppressed patients with non-transplant glomerular disease[J].Int Urol Nephrol,2016,48(11):1863-1871.
[3] 吴 鹰,刘晓莉.系统性红斑狼疮患者C反应蛋白及白细胞与血脂的关系[J].实用医学杂志,214,30(7):1097-1100. Wu Y,Liu XL.The relationship between C reactive protein and whiteblood cell and serum lipids in patients with systemic lupus erythematosus[J].The Journal of Practical Medicine,2014,30(7):1097-1100.
[4] 陈 杰,胡 娜,苏斌涛,等.系统性红斑狼疮患者血清中Tim-1蛋白水平及其基因多态性[J].中国免疫学杂志,2014,30(1):114-116,120. Chen J,Hu N,Su BT,et al.Serum level of Tim-1 protein and genetic variations in Tim-1 gene in patients with systemic lupus erythematosus[J].Chinese Journal of Immunology,2014,30(1):114-116,120.
[5] Han K,Peyret T,Marchand M,et al.Population phar-macokinetics of bevacizumab in cancer patients with external validation[J].Cancer Chemother Pharmacol,2016,78(2):341-351.
[6] Perontsis S,Hatzidimitriou AG,Papadopoulos AN,et al.Nickel-diflunisal complexes:synthesis,characterization,in vitro antioxidant activity and interaction with DNA and albumins[J].J Inorg Biochem,2016,162:9-21.
[7] 黄中伟,陈军浩,张立平.系统性红斑狼疮患者外周血调节性B细胞的检测及意义[J].现代检验医学杂志,2014,29(2):115-116,120. Huang ZW,Chen JH,Zhang LP.Detection of regulatory B cell in peripheral blood form patients with systemic lupus erythematosus[J].Journal of Modern Laboratory Medicine,2014,29(2):115-116,120.
[8] Colina-Vegas L,Dutra JL,Villarreal W,et al.Ru(II)/clotrimazole/diphenylphosphine/bipyridine complexes:Interaction with DNA,BSA and biological potential against tumor cell lines and Mycobacterium tuberculosis[J].J InorgBiochem,2016,162:135-145.
[9] Naz F,Jyoti S,Akhtar N,et al.Effect of oral contraceptive pillson the blood serum enzymes and DNA damage in lymphocytes among users[J].Indian J Clin Biochem,2016,31(3):294-301.
[10] Xu Z,Liu Y,Zhou S,et al.Analysis of the interaction of Dp44mT with human serum albumin and calf thymus DNA using molecular docking and spectroscopic techniques[J].Int J Mol Sci,2016,17(7):1042.
[11] 杜文涵,王 玲,李 慧,等.系统性红斑狼疮患者血清apo M的表达及其与疾病活动度的相关性[J].中南大学学报(医学版),2015,40(4):367-372. Du WH,Wang L,Li H,et al.Association of serum level of apolipoprotein M with disease activity in systemic lupus erythematosus[J].Journal of Central South University(Medical Science),2015,40(4):367-372.
[12] 徐庆雷,朱宝林,马小波,等.系统性红斑狼疮患者外周血CD4+T细胞来源瘦素水平及意义[J].现代检验医学杂志,2013,28(5):30-32,35. Xu QL,Zhu BL,Ma XB,et al.Level of CD4+T cell-derived leptin inperipheral blood mononuclear cells from systemic lupus erythematosus and its significance[J].Journal of Modern Laboratory Medicine,2013,28(5):30-32,35.
[13] Roy AS,Samanta SK,Ghosh P,et al.Cell cytotoxicity and serum albumin binding capacity of the morin-Cu(ii)complex and its effect on deoxyribonucleicacid[J].Mol Biosyst,2016,12(9):2818-2833.
[14] 饶 慧,肖嫦娟,曾清华,等.来氟米特联合糖皮质激素治疗系统性红斑狼疮的临床疗效及对血清IL-8和IL-10水平的影响[J].中国老年学杂志,2015,35(23):6874-6876. Rao H,Xiao CJ,Zeng QH,et al.Effects of leflunomide combined withglucocorticoid on systemic lupus erythematosus and the level of serum IL-8 andIL-10 in patients with systemic lupus erythematosus[J].Chinese Journal of Gerontology,2015,35(23):6874-6876.
[15] 侯秀竹,张 萌,崔丽艳.系统性红斑狼疮患者并发骨质疏松的血清免疫学相关危险因素分析[J].山东医药,2015,55(24):79-80. Hou XZ,Zhang M,Cui LY.Analysis of serum immunological risk factors in patients with systemic lupus erythematosus complicated with osteoporosis[J].Shandong Medical Journal,2015,55(24):79-80.

相似文献/References:

[1]张灵玲,熊大迁,葛一漫,等.血清载脂蛋白M与1-磷酸鞘氨醇在细菌性血流感染中的表达及相关性研究[J].现代检验医学杂志,2019,34(05):56.[doi:10.3969/j.issn.1671-7414.2019.05.014]
　ZHANG Ling-ling,XIONG Da-qian,GE Yi-man,et al.Expression and Correlation of Serum Apolipoprotein M and Sphingosine 1-Phosphate in Bacterial Bloodstream Infection[J].Journal of Modern Laboratory Medicine,2019,34(01):56.[doi:10.3969/j.issn.1671-7414.2019.05.014]

备注/Memo

备注/Memo:
作者简介:曹小燕(1981-),女,本科(学士),讲师/主治医师,研究方向:风湿免疫学,Tel:18154497079,E-mail:caoxiaoyan371@163.com。
通讯作者:付 坤(1982-),女,本科(学士),讲师/主治医师,研究方向:风湿免疫学,Tel:13997815274,E-mail: fukun5535@163.com。
更新日期/Last Update: 2017-01-20