[1]卢美红,杨春兰,景蓉蓉,等.血清人附睾蛋白4表达与慢性肾脏病的相关性研究[J].现代检验医学杂志,2017,32(02):75-77,81.[doi:10.3969/j.issn.1671-7414.2017.02.020]
　LU Mei-hong,YANG Chun-lan,JING Rong-rong,et al.Study on Association with Expression in Patients with Chronic Kidney Disease[J].Journal of Modern Laboratory Medicine,2017,32(02):75-77,81.[doi:10.3969/j.issn.1671-7414.2017.02.020]
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血清人附睾蛋白4表达与慢性肾脏病的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年02期
页码:
75-77,81
栏目:
论著
出版日期:
2017-03-25

文章信息/Info

Title:
Study on Association with Expression in Patients with Chronic Kidney Disease
文章编号:
1671-7414(2017)02-075-04
作者:
卢美红; 杨春兰; 景蓉蓉; 金春景; 丛 辉
南通大学附属医院检验科,江苏南通 226001
Author(s):
LU Mei-hong; YANG Chun-lan; JING Rong-rong; JIN Chun-jing; CONG Hui
Department of Laboratory Medicine, Affiliated Hospital of Nantong University,Jiangsu Nantong 226001,China
关键词:
慢性肾脏病;  人附睾分泌蛋白4;  肾功能
分类号:
R692; R392.11
DOI:
10.3969/j.issn.1671-7414.2017.02.020
文献标志码:
A
摘要:
目的 初步探讨人附睾蛋白4(human epididymal protein 4,HE4)在慢性肾脏病(chronic kidney disease,CKD)中的表达水平及临床诊断价值。方法 收集2014年4月～2015年12月南通大学附属医院确诊为CKD的92例非肿瘤患者及84例健康对照者的血清样本,分别检测尿素氮(blood urea nitrogen,BUN)、血清肌酐(creatinine,Scr)、胱抑素C(cystatin C,Cys C)和β2微球蛋白(β2microglobulin,β2MG)在不同CKD分期中的水平变化,以及HE4浓度与BUN,Scr,Cys C和β2MG浓度的相关性。用ROC曲线评价HE4,BUN,Scr,Cys C和β2MG 这五个指标对CKD辅助诊断价值。结果 肾功能受损的患者血清HE4表达量为388.2(130.1～1 659.5)mIu/L,明显高于对照组的38.1(32.77～48.17)mIu/L,(F=16.237,P=0.001)。随着肾损害的加重患者血清HE4水平也随之逐渐升高,各组间差异有统计学意义(P<0.05)。HE4水平与Cys C,β2MG水平呈正相关,用ROC曲线下面积(area under the curve,AUC)分析血清HE4,BUN,Scr,Cys C和β2MG检测对CKD的诊断效能,结果显示曲线下面积分别为0.878,0.785,0.816,0.874和0.819,HE4有明显的诊断价值。结论 HE4检测时要考虑肾功能受损害的存在,HE4有可能是一种新的CKD早期诊断指标。
Abstract:
Objective To investigate the expression of human epididymal protein 4(HE4)in chronic kidney disease(CKD)and its clinical value.Methods From April 2014 to December 2015,Serum samples of 92 non-cancer patients diagnosed as CKD and 84 healthy controls were collected in Nantong University Hospital.HE4,BUN,Scr,Cys C and β2MG were detected.The difference of HE4 expression in different stages of CKD and the correlation of HE4 with Urea,Scr,Cys C and β2MG were analysized,respectively.ROC curve was used to evaluate the auxiliary diagnostic value of HE4,BUN,Scr,Cys Cand β2MG.Results The serum HE4 expression in patientswith impaired renal function was 388.2(130.1～1 659.5)mIu/L,(F= 16.237,P=0.001).Which was significantly higher than that in the control group [38.1(32.77～48.17)mIu/L].The serum HE4 expression was increased by the stageof renal damage and the difference was existed among different groups(P<0.05).HE4 expression was positive related with Cys C and β2MG.The AUC of HE4,BUN,Scr,Cys C and β2MG were 0.878,0.785,0.816,0.874 and 0.819,respectively.Conlusion It needs to consider the exsits of impaired renal function when the HE4 was detected.The HE4 might be a novel early diagnostic indication for CKD.

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备注/Memo

备注/Memo:
基金项目:江苏省“六大人才高峰”项目(WS-066)。
作者简介:卢美红(1975-),女,硕士,副主任技师,研究方向为临床免疫学检验。
通讯作者:丛 辉,Tel:0513-85052103,E-mail:huicjs@163.com。
更新日期/Last Update: 2017-04-10