[1]赵 娜,王兴宁,贾良勇.HLA-DR53,anti-Sa和anti-CCP抗体联合检测对诊断类风湿关节炎的临床应用价值[J].现代检验医学杂志,2017,32(02):78-81.[doi:10.3969/j.issn.1671-7414.2017.02.021]
　ZHAO Na,WANG Xing-ning,JIA Liang-yong.Diagnostic Value and Significance of the HLA-DR53，Anti-Sa and Anti-CCP Antibody Factors Combination in Rheumatoid Arthritis[J].Journal of Modern Laboratory Medicine,2017,32(02):78-81.[doi:10.3969/j.issn.1671-7414.2017.02.021]
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HLA-DR53,anti-Sa和anti-CCP抗体联合检测对诊断类风湿关节炎的临床应用价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年02期
页码:
78-81
栏目:
论著
出版日期:
2017-03-25

文章信息/Info

Title:
Diagnostic Value and Significance of the HLA-DR53，Anti-Sa and Anti-CCP Antibody Factors Combination in Rheumatoid Arthritis
文章编号:
1671-7414(2017)02-078-04
作者:
赵 娜1; 王兴宁2; 贾良勇2
1.延安大学附属医院心脑血管分院输血科，陕西延安 716000；
2.延安大学附属医院检验科，陕西延安 716000
Author(s):
ZHAO Na1; WANG Xing-ning2; JIA Liang-yong2
1.Department of Blood Transfusion Affiliated Hospital of Yan’an University Cardiovascalar Branch，Shaanxi Yan’an 716000，China；
2.Department of Clinical Laboratory， Affiliated Hospital of Yan’an University，Shaanxi Yan’an 716000，China
关键词:
人类白细胞抗原-DR53; 抗Sa; 抗环瓜氨酸肽; 类风湿关节炎
分类号:
R593.22；R392.11
DOI:
10.3969/j.issn.1671-7414.2017.02.021
文献标志码:
A
摘要:
目的 探究人类白细胞抗原(HLA)-DR53，抗Sa(anti-Sa) 和抗环瓜氨酸肽抗体(anti-CCP)联合检测对诊断类风湿关节炎(RA) 的临床价值。方法 对170例RA患者及50例健康体检者，用PCR-SSP法检测HLA-DR53，ELIS A法检测anti-Sa和anti-CCP抗体，回顾性分析检测结果。结果 RA 患者anti-Sa，HLA-DR53和anti-CCP抗体检测敏感度分别为44.07% (P=0.00，χ2 =165.214)，68.65%(P=0.00，χ2=9.837)和79.45%(P=0.00，χ2=48 .028)，与对照组比较差异均有统计学意义（P<0.01）；相关性分析，HLA-DR53，an ti-CCP和anti-Sa抗体的OR值分别为3.94，38.16和184.52，均为RA关联较强的正相关 危险因素；anti-CCP敏感度、约登指数最高，anti-Sa和anti-CCP抗体并联检测敏感度增 高为88.51%，HLA-DR53和anti-CCP抗体并联检测敏感度高达93.56%，anti-Sa和anti- CCP对检测RA的特异度高达100%。结论 HLA-DR53，anti-CCP和ant i-Sa抗体均是RA的正相关危险因素，联合检测可提高RA的诊断率。
Abstract:
Objective To explore the value of human leucocy te antigen-DR53 (HLA-DR53)，anti-Sa antibody and anti-cyclic citrullinated peptide antibody(anti-CCP) factors combination in rheumatoid arthritis．Methods 170 patients with rheumatoid arthritis and 50 healthy in dividuals in the hospital were chosen．The levels of HLA-DR53 by PCR-SSP，the levels of anti-Sa and anti-CCP by ELISA，compared their diagnostic value by c onsistency analysis and joint detection analysis．Results The sensibility of anti-Sa，HLA-DR53 and anti-CCP in RA were 44.07%(P=0 .00，χ2=165.214)，68.65%(P=0.00，χ2=9.837) and 79.45%(P=0.0 0，χ2=48.028)．Consistency analysis in RA，HLA-DR53，anti-CCP and anti- Sa highly consistent，OR were 3.94，38.6 and 184.52．The sensitivity and Youd en index of anti-CCP were the highest．The sensitivity of anti-Sa and anti-CC P parallelled was 88.51%．The sensitivity of HLA-DR53 and anti-CCP parallelle d was 93.56%，and the specificity of anti-Sa and anti-CCP of RA were 100%．Conclusion There is a certain correlation between　HLA-DR5 3，anti-Sa and anti-CCP antibody，which　are related risk factors of RA，co-d etection will　improve the diagnosis of RA．

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备注/Memo

备注/Memo:
基金项目：延安市惠民计划，项目编号：2015HM-06-01。
作者简介:赵 娜(1967-)，女，本科，副主任检验师，研究方向 ：免疫检验学，Tel：13509110868,E-mail： zhaona197611@163.com。
更新日期/Last Update: 2017-04-10