[1]何金泉,吴彩明,李国强.广东虎门地区健康人群低血红蛋白密度(LHD%)参考区间的建立和临床应用[J].现代检验医学杂志,2017,32(02):86-88，91.[doi:10.3969/j.issn.1671-7414.2017.02.023]
　HE Jin-quan,WU Cai-ming,LI Guo-qiang.Building the Reference Range of Low Hemoglobin Density(LHD%) of Healthy Population in Humen District of Guangdong and Discuss Its Clinical Application Value[J].Journal of Modern Laboratory Medicine,2017,32(02):86-88，91.[doi:10.3969/j.issn.1671-7414.2017.02.023]
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广东虎门地区健康人群低血红蛋白密度(LHD%)参考区间的建立和临床应用()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年02期
页码:
86-88，91
栏目:
论著
出版日期:
2017-03-25

文章信息/Info

Title:
Building the Reference Range of Low Hemoglobin Density(LHD%) of Healthy Population in Humen District of Guangdong and Discuss Its Clinical Application Value
文章编号:
1671-7414(2017)02-086-04
作者:
何金泉; 吴彩明; 李国强
东莞市虎门医院检验科,广东东莞 523900
Author(s):
HE Jin-quan; WU Cai-ming; LI Guo-qiang
Department of Clinical Laboratory, Humen Hospital of Dongguan City,Guangdong Dongguan 523900,China
关键词:
低血红蛋白密度;  参考区间;  缺铁性贫血;  价值
分类号:
R446.111
DOI:
10.3969/j.issn.1671-7414.2017.02.023
文献标志码:
A
摘要:
目的 建立广东虎门地区健康人群低血红蛋白密度(low hemoglobin density,LHD%)的参考区间,并探讨其临床应用价值。方法 选取2015年1月～2016年9月来东莞市虎门医院体检的健康人群1 650例为对照组,并选择同期经临床确诊为缺铁性贫血(iron-deficiency anemia,IDA)患者67例为IDA组,分别采用Sysmex XT-1800i全自动血细胞分析仪检测血常规,然后根据平均血红蛋白浓度(mean corpuscular hemoglobin concentration,MCHC),计算低血红蛋白密度(LHD%),并对结果进行统计分析。结果 对照组健康人群LHD%值为2.41%±0.85%,95%参考区间为0.74%～4.08%,男性高于女性,差异有统计学意义(t=3.209,P<0.05)。IDA组患者治疗前LHD%为30.97%±18.65%,明显高于对照组,差异有统计学意义(t=19.536,P<0.01),且与血红蛋白(Hb)水平呈负相关性(r=-0.4313)。IDA组患者治疗后LHD%值均明显降低,但恢复速度比Hb和MCHC慢。通过ROC曲线分析,当LHD%的cut-off值为4.10%时,LHD%用于IDA早期诊断的敏感度为96.78%,特异度为100%。结论 建立了广东虎门地区健康人群LHD%的正常参考区间,LHD%是IDA早期诊断和疗效动态监测的良好指标。
Abstract:
Objective To establishe the reference range oflow hemoglobin density(LHD%)of health population in Humen District of Guangdong,and discuss the clinical application value.Methods Randomly selected from January 2015 to September 2016 in Humen Hospital of Dongguan City physical examination of 1 650 cases of healthy people as control group,and selected the same period by the clinical diagnosis of iron deficiency anemia(iron-deficiency anemia,IDA)group,67 cases of patients with IDA Sysmex XT-1800i fully automatic blood analyzer were used respectively to detect blood routine,and then based on the average haemoglobin concentration(mean corpuscular hemoglobin concentration,MCHC),calculate the LHD%,and the calculation resultswere analyzed.Results The control healthy crowd LHD% value was 2.41%±0.85%,95% reference range was 0.74%～4.08%,male was higher than the female,the difference was statistically significant(t=3.209,P<0.05).IDA patients before treatment LHD% was 30.97%±18.65%,significantly higher than the control group,the difference was statistically significant(t=19.536,P<0.01),and with the level of hemoglobin(Hb)showed a negative correlation(r=-0.4313).LHD% values after treatment in patients with IDA groupwere significantly lower,but the recovery speed was slower than the Hb and MCHC.By ROC curve analysis,when the cut-off of LHD% value was 4.10%,the LHD% for IDA early diagnostic sensitivity of 96.78%,specificity of 100%.Conclusion Established the reference range of low hemoglobin density(LHD%)of healthy population in Humen district of Guangdong,and LHD% is IDA goodindicator of early diagnosis and curative effect of dynamic monitoring.

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备注/Memo

备注/Memo:

作者简介:何金泉(1978-),男,本科,学士,主管技师,主要从事临床检验工作,Tel:13729992029,E-mail:zengsiqiang@163.com。
更新日期/Last Update: 2017-04-10