[1]周 玉,曲 芬,龚美亮,等.老年住院患者感染鲍曼不动杆菌克隆相关性及耐药表型分析研究[J].现代检验医学杂志,2017,32(03):14-17.[doi:10.3969/j.issn.1671-7414.2017.03.004]
　ZHOU Yu,QU Fen,GONG Mei-liang,et al.Clonal Relatedness and Antimicrobial Susceptibility Profiling of Acinetobacter Baumannii Isolates from Senile Patients[J].Journal of Modern Laboratory Medicine,2017,32(03):14-17.[doi:10.3969/j.issn.1671-7414.2017.03.004]
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老年住院患者感染鲍曼不动杆菌克隆相关性及耐药表型分析研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年03期
页码:
14-17
栏目:
论著
出版日期:
2017-05-25

文章信息/Info

Title:
Clonal Relatedness and Antimicrobial Susceptibility Profiling of Acinetobacter Baumannii Isolates from Senile Patients
文章编号:
1671-7414 (2017)03-014-04
作者:
周 玉1; 曲 芬2; 龚美亮1; 徐雅萍1; 陈素明2;  丛玉隆1; 邓新立1
1.解放军总医院南楼检验科，北京 100853；
2.302医院临床检验中心 ，北京 100039
Author(s):
ZHOU Yu1; QU Fen2; GONG Mei-liang1; XU Ya-ping 1; CHEN Su-ming2;  CONG Yu-long1; DENG Xin-li1
1．Department of Clinical Lab oratory in Nanlou， PLA General Hospital，Beijing 100853，China；
2.Diagnostic Center of Clin ical Laboratory， the 302nd Hospital of the People’s Liberation Army，Beijing 100039，China
关键词:
鲍曼不动杆菌; 医院获得性感染; 泛耐药; 分子流行病学
分类号:
R378；R446.5
DOI:
10.3969/j.issn.1671-7414.2017.03.004
文献标志码:
A
摘要:
目的 对分离自老年住院患者的鲍曼不动杆菌药物敏感性和 基因型进行横向和纵向分析，以获得其耐药表型及克隆相关性。方法 〖HT5”K 〗横向分析对象是2013～2014年间分离自170例老年住院患者的170株鲍曼不动杆菌，纵向 分析对象是随机选择8例长期感染鲍曼不动杆菌的老年患者，共收集77株反复分离出的菌株 。结果 170株非重复菌株中75.3%对碳青霉烯类药物不敏感，表现 为泛耐药或多重耐药，分布在老年病房的各个科室；通过脉冲电场凝胶电泳(PFGE)把170株 菌分为36个型，其中I型(共119株菌)为主要流行株，表现为泛耐药。纵向研究中，77株菌都 为泛耐药表型，PFGE分型显示其中76株菌都属于I型。结论 泛耐药 鲍曼不动杆菌在该院老年病房肆虐流行，克隆播散是其最主要的传播方式。相关人员需要加 强管控措施阻断人与 人之间的水平传播，阻止泛耐药菌的继续播散。
Abstract:
Objective To investigate the clonal relatedness of A．baumannii isolates from senile patients by conducting cross-sectiona l and longitudinal studies on antimicrobial susceptibility profiling and genomic diversity．Methods Cross-sectional study was done among the 170 non-repetitive A．baumannii isolates which were collected from sen ile patients during two years．Longitudinal study was conducted among 77 A．ba umannii collected from 8 senile patients within longtime hospitalization．Results 75.3% of the 170 isolates were non-susceptible to c arbapenems，and the phenotype were XDR or MDR which spread evenly all over the s enile wards．The isolates belonged to 36 pulsotypes determined by PFGE．Groups I (contain119 isolates) were major epidemic strains，which were CRAB with XDR phe notype．In longitudinal study，comparison of pulsotypes was performed for each p atient and all isolates were clustered into group I except one isolate．All the 77 isolates were XDR．Conclusion Extensive drug-resistan ce of A．baumannii was a serious problem in the gerontal wards．Clone dissem ination was the most important style of XDR strains spread．Horizontal infection control measures to interrupt person-to-person transmission should be reinfor ced to reduce the further spread of XDR A．baumannii．

参考文献/References:

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备注/Memo

备注/Memo:
基金项目：全军医学科技“十二五”科研项目重点课题(BWS11-C073)。
作者简介：周 玉(1982-)，女，博士，主治医师，主要研究方 向：临床微生物诊断及耐药监测，E-mail：zhouy427@163.com。
通讯作者：邓新立(1969-)，男，博士，副主任医师，E-mail：b jdxl@163.com。
更新日期/Last Update: 2017-06-25