[1]程俊杰,李 静,梁西强,等.高血压并发脑梗死患者不同血脂分层下病死率的分析研究[J].现代检验医学杂志,2017,32(03):97-100.[doi:10.3969/j.issn.1671-7414.2017.03.026]
 CHENG Jun-jie,LI Jing,LIANG Xi-qiang,et al.Significance on Cerebral Infarction’s Fatality Rate for the Retrospective Analysis of Hypertension under Serum Lipids Layer Management[J].Journal of Modern Laboratory Medicine,2017,32(03):97-100.[doi:10.3969/j.issn.1671-7414.2017.03.026]
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高血压并发脑梗死患者不同血脂分层下病死率的分析研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年03期
页码:
97-100
栏目:
论著
出版日期:
2017-05-25

文章信息/Info

Title:
Significance on Cerebral Infarction’s Fatality Rate for the Retrospective Analysis of Hypertension under Serum Lipids Layer Management
文章编号:
1671 -7414(2017)03-097-04
作者:
程俊杰12李 静3梁西强1段霞霞1肖 尧1郭 炫1
1.西安交通大学第一附属医院检验科,西安 710061;
2.陕西省核工业二一五医院检验科,陕西咸阳 712000;
3.西安市中心医院输血科 ,西安 710003
Author(s):
CHENG Jun-jie12LI Jing3LIANG Xi-qiang 1DUAN Xia-xia1XIAO Rao1GUO Xuan1
1.Department of Clinical Laboratory,the First Affiliated Hospi tal of Xi’an Jiaotong University,Xi’an 710061,China;
2.Department of Clinical Labor atory, Nuclear Industry 215 Hospital of Shaanxi Province,Shaaxi Xianyang 712000 ,China;
3.Departmen
关键词:
血脂分层管理H型高血压脑梗死病死率
分类号:
R544.11;R446.112
DOI:
10.3969/j.issn.1671-7414.2017.03.026
文献标志码:
A
摘要:
目的 通过分析高血压并发脑梗死患者在不同血脂分层下病 死率的情况,阐明血脂分层管理在高血压治疗中的意义。方法 604 例高血压并发脑梗死患者根据血脂分层管理的要求分为中危组(198例),高危组(198例)和极 高危组(208例),并将各组根据血清中HCY(同型半胱氨酸)水平,分为H型高血压亚组(HCY<10 μmol/L)与单纯高血压亚组(HCY<10 μmol/L),比较各组患者10年病死率的情况。〖HT 5”H〗结果 H型高血压亚组与单纯高血压亚组间病死率比较,其中中危组中两 亚组间比较,差异有统计学意义(χ2= 5.095,P=0.024 205),极高危组中两亚组 间比较,差异有统计学意义(χ2= 7.859,P=0.005 056),高危组中两亚组间比较 ,差异有统计学意义(χ2= 9.961,P=0.001 599)。单纯高血压亚组中不同血脂分 层组间病死率比较,其中高危组与中危组组间比较,差异有统计学意义(χ2=6.575,P =0.010 343),极高危组与高危组组间比较,差异有统计学意义(χ2=6.868,P= 0.008 774)。H型高血压亚组中组间病死率比较,其中极高危组与高危组组间比较,差异 有统计学意义(χ2=4.745,P=0.029 388), 高危组与中危组组间比较,差异有统 计学意义(χ2=11.668,P=0.000 636)。结论 高血脂尤其 是高LDL以及高HCY是引起高血压并发脑梗死患者死亡的重要原因,临床可通过血脂分层管理 有指导性地降低LDL水平以及通过加强对HCY水平的控制来降低患者病死率,提高患者生存率 。
Abstract:
Objective By analyzing the mortality of patient s with hypertension and cerebral infarction in different blood lipid stratifica tion,the significance of blood lipid stratification management in the treatment of hypertension was clarified.Methods 604 patients with hypertension combined with cerebral infarction were divided into middle risk g roup (198 cases),high risk group (n=198) and extremely high risk group (n =208) and each group of different stratification according to the serum lipid HCY level,divided into H type hypertension group (HCY=10 μmol/L) and hy pertension group ((HCY<10 μmol/L group) and comparison of the 10 year mortalit y in each group.Results Comparison of mortality between H type hypertension group and simple hypertension group,among them,the differe nce between the two groups in middle risk group was statistically significant ( χ2=5.095,P=0.024 205).The difference between the two groups in extrem ely high risk group was statistically significant (χ2=7.859,P=0.005 05 6).The difference between the two groups in high risk group was statistically s ignificant (χ2=9.961,P=0.001 599).There was a significant difference in mortality between the groups with different blood lipids in simple hypertensi on group.Among the high-risk group and the middle risk group,the difference w as statistically significant (χ2=6.575,P=0.010 343),and there was sig nificant difference between high risk group and high risk group (χ2=6.868 ,P=0.008 774).Comparison of mortality between different lipid levels in H t ype hypertension group,the difference was statistically significant.There was significant difference between the extremely high risk group and the high risk g roup (χ2=4.745,P=0.029 388) and there was significant difference betwe en the high risk gro up and the middle risk group (χ2=11.668,P=0.000 636).Concl usion Hyperlipidemia,especially high LDL and high HCY are the main causes of death in patients with hypertension complicated with cerebral infarcti on,the clinical use of blood lipid levels can reduce the level of LDL and reduc e the mortality of patients by strengthening the control of HCY level.Improve t he survival rate of patients.

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备注/Memo

备注/Memo:
作 者简介:程俊杰(1969-),男,研究生,副主任技师,主攻临床检验诊断,E-mai l:953598984@qq.com。
通讯作者:郭 炫,主任技师,研士研究生导师,E-mail:3504 49850@qq.com。
更新日期/Last Update: 2017-06-25