[1]施瑞洁,闫福堂,刘文康,等.西安地区健康人群血清NGAL参考值范围的调查[J].现代检验医学杂志,2017,32(04):130-132.[doi:10.3969/j.issn.1671-7414.2017.04.037]
　SHI Rui-jie,YAN Fu-tang,LIU Wen-kang,et al.Investigation on the Serum NGAL Reference Range of Healthy Populations in Xi'an[J].Journal of Modern Laboratory Medicine,2017,32(04):130-132.[doi:10.3969/j.issn.1671-7414.2017.04.037]
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西安地区健康人群血清NGAL参考值范围的调查()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年04期
页码:
130-132
栏目:
论著
出版日期:
2017-07-25

文章信息/Info

Title:
Investigation on the Serum NGAL Reference Range of Healthy Populations in Xi'an
文章编号:
1671-7414(2017)04-130-03
作者:
施瑞洁; 闫福堂; 刘文康; 张 华; 袁 军; 弥 鹏; 胡淑玲; 郑 霄
陕西省人民医院检验科,西安 710068
Author(s):
SHI Rui-jie; YAN Fu-tang; LIU Wen-kang;  ZHANG Hua; YUAN Jun; MI Peng; HU Shu-ling; ZHENG Xiao
Department of Clinical Laboratory,Shaanxi Provincial People'sHospital,Xi'an 710068,China
关键词:
血清;  中性粒细胞明胶酶相关性脂质运载蛋白;  健康人群;  参考值
分类号:
R446.112
DOI:
10.3969/j.issn.1671-7414.2017.04.037
文献标志码:
A
摘要:
目的 建立西安地区健康人群血清中性粒细胞明胶酶相关脂质运载蛋白(NGAL)的参考区间。方法 选取2014年3月～2016年10月于陕西省人民医院体检中心健康查体者2 665例(年龄6～95岁,男性1 370例,女性1 295例); 来医院预防接种的学龄前儿童682例(年龄0～6岁,男性356例,女性326例)。采用胶乳增强免疫比浊法在Beckman-AU5800全自动生化分析流水线上测定血清NGAL浓度,检测数据进行统计学分析,然后建立西安地区人群不同年龄、性别血清NGAL参考值范围。结果 血清NGAL水平在健康人群中呈偏态分布,其中6岁以下学龄前儿童为37.66±23.12 ng/ml,6～15岁为39.25±25.34 ng/ml,16～49岁为46.68±27.06 ng/ml,50～69岁为57.82±29.13 ng/ml,前二者与后者比较差异有统计学意义(t=0.589,P<0.05); 而70岁以上为61.87±32.64 ng/ml,15～49岁与70～91岁比较差异有统计学显著性意义(t=8.529,P<0.01)。同时经相关性分析,血清NGAL与年龄较为密切(r=0.298,P<0.01)。而男女之间血清NGAL水平的差异无统计学意义(t=0.263～0.542,均P>0.05)。以50岁为分界年龄,以87.0 ng/ml为参考值上限。结论血清NGAL水平与年龄有关,且随着年龄的增长而呈上升趋势,而与性别无关。
Abstract:
Objective To establish serum NGAL reference range of healthy populations in Xi'an Area.Methods 2 665 cases(aged 6 to 95 years old,male 1 370,female 1 295)of health-check peoplewere collected from March 2014 to October 2016 in Medical Examination Center ofShaanxi Provincial People's Hospital,and 682 cases(aged 0 to 6 years old,male 356,female 326)were collected from preschool children of prevention.SerumNGAL concentration of them were analysed by immunoturbidimetry method with theAutomatic Biochemical Analysis Assembly Line of Beckman-AU5800,and the detection data for statistical analysis.Then established the reference range of serumNGAL population of different age and different sex in Xi'an.Results The serum NGAL levels in healthy subjects showed a skewed distribution,which were preschool children under 6 years of age 37.66±23.12 ng/ml,6～15 years 39.25±25.34 ng/ml,16～49 years 46.68±27.06 ng/ml,and 50～69 years 57.82±29.13 ng/ml.Compared the first two with the latter,there was a significant difference(t=0.589,P<0.05).The serum NGAL levels of over 70years were 61.87±32.64 ng/ml,and there was a significant difference betweenthe ages of 15 and 49 and over 70 years(t=8.529,P<0.01).At the same time,the serum NGAL was closely correlated with age(r=0.298,P<0.01).But there was no significant difference in serum NGAL level between male and female(t=0.263～0.542,all P>0.05).87ng/ml was the upper limit of the reference value for the age of 50 years.Conclusion The level of serum NGAL was related to age and increased with age,but not with gender.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:施瑞洁(1971-),女,主管检验师,擅长临床生化、临床体液和血液检验及相关研究,E-mail: xasrj001@163.com。 通讯作者:张 华,女,主管检验师,擅长临床生化、免疫检验及相关研究,E-mail:zhanghua@126.com。
更新日期/Last Update: 1900-01-01