[1]朱文芳,沈建军,韩 双,等.血清Lp-PLa2,Hcy及CysC联合检测在妊娠期高血压诊断中的临床意义[J].现代检验医学杂志,2017,32(05):55-58.[doi:10.3969/j.issn.1671-7414.2017.05.015]
　ZHU Wen-fang,SHEN Jian-jun,HAN Shuang,et al.Clinical Significance of Combined Detection of Serum Lp-PLa2,Hcy and CysC for the Diagnosis of Hypertensive Disorder Complicating Pregnancy[J].Journal of Modern Laboratory Medicine,2017,32(05):55-58.[doi:10.3969/j.issn.1671-7414.2017.05.015]
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血清Lp-PLa2,Hcy及CysC联合检测在妊娠期高血压诊断中的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年05期
页码:
55-58
栏目:
论著
出版日期:
2017-11-02

文章信息/Info

Title:
Clinical Significance of Combined Detection of Serum Lp-PLa2,Hcy and CysC for the Diagnosis of Hypertensive Disorder Complicating Pregnancy
文章编号:
1671-7414(2017)05-055-04
作者:
朱文芳1; 沈建军1; 韩 双1; 邹爱民1; 张静1
1.长安医院检验科,西安 710016; 2.第四军医大学唐都医院检验科,西安 710038
Author(s):
ZHU Wen-fang1; SHEN Jian-jun2; HAN Shuang1; ZOU Ai-min1; ZHANG Jing1
1.Department of Clinical Laboratory,Changan Hospital,Xi'an 710016,China; 2.Department of Clinical Laboratory,Tangdu Hospital of the Fourth Military Medical University,Xi'an 710038,China
关键词:
妊娠高血压综合症;  血清脂蛋白磷脂酶a2;  血清同型半胱氨酸;  血清胱抑素C
分类号:
R714.252; R446.112
DOI:
10.3969/j.issn.1671-7414.2017.05.015
文献标志码:
A
摘要:
目的 探讨血清脂蛋白相关磷脂酶a2(Lp-PLa2)、同型半胱氨酸(Hcy)与胱抑素C(CysC)联合检测在妊娠期高血压综合征(HDCP)诊断的临床意义。方法 选取2013年1月～2016年5月长安医院就诊的113例妊娠期高血压患者为观察组,分为A,B,C三组(A组为妊娠高血压患者55例、B组为轻度子痫前期患者32例、C组为重度子痫前期患者26例),同时选择该院同期50例正常妊娠者作为对照组,检测血清Lp-PLa2(酶联免疫法)、Hcy(循环酶法)以及CysC(微粒子增强免疫比浊法),对检测结果进行比较分析。结果 血清Lp-PLa2,Hcy和CysC检测结果在对照组、观察组A、观察组B及观察组C呈递增性升高,以观察组C升高最明显,与对照组相比观察组血清Lp-PLa2,Hcy和CysC检测结果明显升高,差异有统计学意义(F=8.102,7.231,6.926,均P<0.05); Pearson相关性分析结果显示血清Lp-PLa2,Hcy和CysC检测结果与血压之间存在正相关关系(r=0.71,0.69,0.63,均P<0.05); 血清Lp-PLa2,Hcy及CysC三项联合检测异常率高于单项检测异常率,差异有统计学意义(χ2=6.725,P<0.001); 且血清Lp-PLa2,Hcy及Cys单项检测结果异常率随着HDCP病情的加重而升高,差异具有统计学意义(χ2 =9.351,P<0.000)。结论 血清Lp-PLa2,Hcy和CysC与妊娠期高血压综合征的发生、发展密切相关,联合检测有利于提高HDCP异常结果的检出率,对HDCP早期诊断及预后判断具有重要临床意义。
Abstract:
Abstract:Objective To investigate the clinical significance of combined detection of lipoprotein associated serum phospholipase A2(Lp-PLa2),homocysteine(Hcy)and cystatin C(CysC)in the diagnosis of hypertensivedisorders complicating pregnancy(HDCP).Methods From January 2013 to May 2016 in Changan Hospital,selected 113 cases of pregnancy induced hypertension patients as the observation group,and were divided into three group A,B and C(group A:55 cases of HDCP patients,group B:32 cases of mild preeclampsia and group C for patients with severe preeclampsia 26 cases).At the same period,selected 50 cases of normal college pregnancy as control group,serum Lp-PLa2(enzyme-linked immunosorbent assay),Hcy(cyclophorase method)and CysC(particle enhanced turbidimetric method),the test results were analyzed and compared.Results Serum Lp-PLa2,Hcy and CysC test results in the control group,the observation group A,observation group B and observation group C increased significantly,in the observation group C increased most obviously.Compared with the control group,the serum levels of Lp-PLa2,Hcy and CysC in the observation group were significantly higher,the difference was statistically significant(F=8.102,7.231 and 6.926,all P<0.05).Pearson correlation analysis showed that there was a positive correlation between serum Lp-PLa2,Hcy and CysC and blood pressure(r=0.71,0.69,0.63,all P<0.05).The abnormal rate of serum Lp-PLa2,Hcy and CysC for three joint detection was higher than that of single detection,and the difference was statistically significant(χ2 =6.725,P<0.001).The abnormal rate of serum Lp-PLa2, Hcy and Cys single test results increased with the exacerbation of HDCP,and the difference was statistically significant(χ2=9.351,P<0.000).Conclusion Serum Lp-PLa2,Hcy,CysC and pregnancy would be closely related to the occurrence and development of hypertension syndrome,so combined detection of HDCP can improve the detection rate of abnormal results,and it has important clinical significance for early diagnosis and prognosis of HDCP.

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备注/Memo

备注/Memo:
作者简介:朱文芳(1976-),女,本科,主管检验师,研究方向临床生物化学检验,E-mail:qq15728784@sina.com。
更新日期/Last Update: 1900-01-01