[1]白香妮,张 英.血清Cys C,NGAL及尿IL-18对ICU儿童急性肾损伤的早期诊断价值[J].现代检验医学杂志,2017,32(05):104-107.[doi:10.3969/j.issn.1671-7414.2017.05.017]
　BAI Xiang-ni,ZHANG Ying.Early Diagnostic Value of the Detection of Serum Cys C,NGAL and Urinary IL-18 for Acute Kidney Injury in Pediatric Intensive Care Units[J].Journal of Modern Laboratory Medicine,2017,32(05):104-107.[doi:10.3969/j.issn.1671-7414.2017.05.017]
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血清Cys C,NGAL及尿IL-18对ICU儿童急性肾损伤的早期诊断价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年05期
页码:
104-107
栏目:
论著
出版日期:
2017-11-02

文章信息/Info

Title:
Early Diagnostic Value of the Detection of Serum Cys C,NGAL and Urinary IL-18 for Acute Kidney Injury in Pediatric Intensive Care Units
文章编号:
1671-7414(2017)05-104-04
作者:
白香妮1; 张 英2
1.西电集团医院检验科,西安 710077; 2.西电集团医院西开分院检验科,西安 710077
Author(s):
BAI Xiang-ni1; ZHANG Ying2
1.Department of Clinical Laboratory,Xidian Group Hospital,Xi'an 710077,China; 2.Department of Clinical Laboratory, the Xikai Branch of Xidian Group Hospital,Xi'an 710077,China
关键词:
急性肾损伤;  血清胱抑素C;  中性粒细胞明胶酶相关脂质运载蛋白;  白介素-18
分类号:
R692; R392.11
DOI:
10.3969/j.issn.1671-7414.2017.05.017
文献标志码:
A
摘要:
目的 探讨血清胱抑素C(Cys C)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)及尿白细胞介素-18(IL-18)对ICU重症儿童急性肾损伤(AKI)的早期诊断价值。方法 选取2015年6月～2017年2月入住西电集团医院ICU的重症患儿114例作为研究对象,根据患儿是否继发AKI,将其分为AKI组(64例)和非AKI组(50例),同时从同期健康体检者中选取50例作为对照组。检测各组受试者血肌酐(Scr)、尿素(BUN)、血清Cys C,NGAL及IL-18水平; 采用Pearson分析法分析AKI组患儿各指标间相互关系; 通过AKI患儿工作特征曲线(ROC)分析血清Cys C,NGAL及尿IL-18在AKI诊断中的价值。结果 AKI组患儿Scr,BUN,血清Cys C,NGAL及尿IL-18水平均明显高于非AKI组和对照组,差异均具有统计学意义(t=3.137～28.642,t1=7.653～33.672,均P<0.05); 血清Cys-C,NGAL水平与Scr水平呈正相关(Beta=0.273,0.514,均P<0.05),尿IL-18水平与血清清蛋白(Alb)呈负相关(Beta=-0.342,P<0.05); 血清Cys C,NGAL及尿IL-18 ROC曲线下面积(ACU)分别为0.872(95% CI:0.831～0.936),0.823(95% CI:0.641～0.925)和0.714(95%CI:0.598～0.833)。结论 血清Cys C及NGAL水平升高早于Scr,可作为ICU重症儿童AKI早期临床诊断的可靠指标。
Abstract:
Abstract:Objective To explore the diagnosis value of serum cystatin C(Cys C),neutrophil gelatinase-associated lipocalin(NGAL)and urinary interleukin-18(IL-18)levels in critically cases from pediatric Intensive Care Units(ICU).Methods 114 cases from June 2015 toJanuary 2017 in Xidian Group Hospital were enrolled in the study.According to whether cases secondary to AKI,they were divided into AKI group(64 cases)and non-AKI group(50 cases).At same time 50 healthy cases were selected as the control group.TheSerum creatinine(Scr),urinary nitrogen(BUN),Cys C,NGAL and urinary IL-18 levels were measured in each subject.The relationship between the indexes of AKIgroup was analyzed by Pearson analysis.The value of serum Cys-C,NGAL and urinary IL-18 in the diagnosis of AKI was analyzed by receiver operating characteristic(ROC)curve.Results Serum Cys-C,NGAL and urinaryIL-18 levels of the AKI group were higher than that of the non-AKI group andthe control group,the difference had statistical significance(t=3.137～28.642,t1=7.653～33.672,all P<0.05).The levels of serum Cys-C and NGAL were positively correlated with Scr levels(Beta=0.273,0.514,all P<0.05).The urinary IL-18 levels were negatively correlated with serum albumin(Alb)(Beta=-0.342,P<0.05).The area under the ROC carve(AUC)of serum Cys-C,NGAL and urinary IL-18 was 0.872(95% CI:0.831～0.936),0.823(95%CI:0.641～0.925)and 0.714(95%CI:0.598～0.833).Conclusion The levels of serum Cys-C and NGAL were elevated earlier than Scr,andit can be used as reliable indicators of early diagnosis of early cases AKI in ICU.

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备注/Memo

备注/Memo:
作者简介:白香妮(1976-),女,大专,主管检验师,主要研究方向:医学检验,E-mail:baixiangni123@163。 通讯作者:张 英。
更新日期/Last Update: 1900-01-01