[1]刘 玥,刘西玲,张 欣,等.Lp-PLA2,Hcy,HbA1c,LDL-C水平与脑微出血相关性研究[J].现代检验医学杂志,2017,32(06):35-38.[doi:10.3969/j.issn.1671-7414.2017.06.001]
　LIU Yue,LIU Xi-ling,ZHANG Xin,et al.Study on the Relationship between Lipoprotein-Related Phospholipase A2,Homocysteine,Beta-N-1-Deoxy Fructosyl Component of Hemoglobin and Cerebral Microbleeds[J].Journal of Modern Laboratory Medicine,2017,32(06):35-38.[doi:10.3969/j.issn.1671-7414.2017.06.001]
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Lp-PLA2,Hcy,HbA1c,LDL-C水平与脑微出血相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年06期
页码:
35-38
栏目:
论著
出版日期:
2017-12-25

文章信息/Info

Title:
Study on the Relationship between Lipoprotein-Related Phospholipase A2,Homocysteine,Beta-N-1-Deoxy Fructosyl Component of Hemoglobin and Cerebral Microbleeds
文章编号:
1671-7414(2017)06-035-04
作者:
刘 玥; 刘西玲; 张 欣; 侯 辰; 唐 鹏
陕西省人民医院 神经内三科,西安 710068
Author(s):
LIU Yue; LIU Xi-ling; ZHANG Xin; HOU Chen; TANG Peng
the Third Department of Neurology,Shaanxi Provincial People's Hospital,Xi'an 710068,China
关键词:
脑微出血;  脂蛋白相关磷脂酶A2;  同型半胱氨酸;  糖化血红蛋白;  低密度脂蛋白胆固醇
分类号:
R743.34; R446.112
DOI:
10.3969/j.issn.1671-7414.2017.06.001
文献标志码:
A
摘要:
目的 研究脑微出血(cerebral microbleeds,CMBs)患者脂蛋白相关磷脂酶A2(lipoprotein associated phospholipase A2,Lp-PLA2)、血同型半胱氨酸(homocysteine,Hcy)、糖化血红蛋白(beta-N-1-deoxy fructosyl component of hemoglobin,HbA1c)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)水平与脑微出血的相关关系。方法 采用2014年中国脑小血管病诊治共识定义,连续纳入2016年1月～2017年1月就诊于陕西省人民医院的CMBs患者62例(男性48例,女性14例),正常对照组30例(男性20例,女性10例),采集人口学资料及病史。对两组人群进行Lp-PLA2,Hcy,HbA1c和LDL-C的检查。比较两组间Lp-PLA2,Hcy,HbA1c和LDL-C水平的差异,并统计CBMs组各检验指标与CMBs数量及发生部位的相关关系。结果 CMBs组的Lp-PLA2(202.22±109.52 ng/ml),Hcy(21.42±14.62 μmol/L),HbA1c(6.42%±1.29%)水平均高于对照组(分别为110.11±38.51 ng/ml,15.09±5.72 μmol/L和5.81%±0.52%),差异具有统计学意义(t=2.67,2.97和3.24,P值均<0.05)。CMBs患者中,HbA1c水平与CMBs数量具有相关性(r=0.287,P=0.024),HbA1c水平与脑深部CMBs数量相关(r=0.304,P=0.016),而与脑皮质CMBs数量无明显相关(P>0.05)。结论 CMBs患者的Lp-PLA2,Hcy和HbA1c水平均高于正常人群。HbA1c水平与CMBs数量具有相关性,主要与脑深部CMBs数相关。
Abstract:
Abstract:Objective To investigate the relationship between lipoprotein-related phospholipase A2(Lp-PLA2),homocysteine(Hcy),beta-N-1-deoxy fructosyl component of hemoglobin(HbAlc),low density lipoprotein cholesterol(LDL-C)and cerebral microbleeds in patients.Methods Patients with CMBs were consecutively recruited from the Department of Neurology,in Shaanxi Provincial People's Hospital by using the diagnostic criteria according to the diagnosis and treatment of cerebralcerebrovascular disease in China in 2014.In addition,volunteers were includedas normal controls.The demographic characteristics and the history of patientswere collected.The level of Lp-PLA2,Hcy,HbA1c and LDL-C in each group was analyzed.Results 62 patients with CMBs were included in this study,including 48 males and 14 females.30 patients were included into thenormal control group,including 20 males and 10 females.The levels of Lp-PLA2,Hcy and HbA1c in the CMBs group were significantly higher than those in the control group(t=2.67,2.97,3.24,P<0.05).The level of HbA1c levels were correlated with the number of CMBs(r=0.287,P=0.024).The level ofHbA1c was correlated with the number of CMBs in deep white matter(r=0.304,P=0.016),while it was not correlated with the number of CMBs in the cortex(P>0.05).Conclusion The levels of Lp-PLA2,Hcy andHbA1c in CMBs were higher than those in normal control group.HbA1c levels were associated with the number of CMBs,especially in deep white matter.

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备注/Memo

备注/Memo:
作者简介:刘 玥(1983-),女,硕士,神经内科主治医师,研究方向:缺血性脑血管病的病因及个体化防治的相关研究,E-mail:june0420@sina.com。 通讯作者:刘西玲,E-mail:liuxiling0220@163.com。
更新日期/Last Update: 2017-12-26