[1]李 薪,魏力强.2型糖尿病患者血清中脂蛋白相关磷脂酶A2检测的临床意义[J].现代检验医学杂志,2017,32(06):85-88.[doi:10.3969/j.issn.1671-7414.2017.06.001]
　LI Xin,WEI Li-qiang.Clinical Significance of Detection of Lipoprotein Associated Phospholipase A2 in Serum of Patients with Type 2 Diabetes Mellitus[J].Journal of Modern Laboratory Medicine,2017,32(06):85-88.[doi:10.3969/j.issn.1671-7414.2017.06.001]
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2型糖尿病患者血清中脂蛋白相关磷脂酶A2检测的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年06期
页码:
85-88
栏目:
论著
出版日期:
2017-12-25

文章信息/Info

Title:
Clinical Significance of Detection of Lipoprotein Associated Phospholipase A2 in Serum of Patients with Type 2 Diabetes Mellitus
文章编号:
1671-7414(2017)06-085-04
作者:
李 薪1; 魏力强2
1.西安医学院2015级硕士研究生,西安 710021; 2.陕西省人民医院 陕西省临床检验中心,西安 710068
Author(s):
LI Xin1; WEI Li-qiang2
1.Graduate Students of Xi'an Medical University in Grade 2015,Xi'an 710021,China; 2.Shaanxi Clinical Laboratory Center,Shaanxi Provincial People's Hospital,Xi'an 710068,China
关键词:
脂蛋白相关磷脂酶A2;  2型糖尿病;  高脂血症;  动脉粥样硬化
分类号:
R587.1; R446.112
DOI:
10.3969/j.issn.1671-7414.2017.06.001
文献标志码:
A
摘要:
目的 通过检测2型糖尿病患者血清中脂蛋白相关磷脂酶A2(Lp-PLA2)水平,分析Lp-PLA2与2型糖尿病的关系,并进一步探讨Lp-PLA2在2型糖尿病并发症的发生、发展中的作用及临床意义。方法 选择陕西省人民医院内分泌科2型糖尿病住院患者189例,将其分为3组,包括单纯2型糖尿病患者49例,2型糖尿病并发高脂血症患者56例,2型糖尿病并发动脉粥样硬化患者84例,同期选择正常对照组65例,分别检测Lp-PLA2,HbA1c质量水平,对各组间的结果进行比较。结果 单纯2型糖尿病组(184.83±23.33 ng/ml)、2型糖尿病并发高脂血症组(204.06±28.05 ng/ml)、2型糖尿病并发动脉粥样硬化组(231.50±38.19 ng/ml)Lp-PLA2水平均高于对照组(88.51±21.91 ng/ml),四组间的差异具有统计学意义(F=194.78,P<0.01)。在单纯2型糖尿病组中对HbA1c与Lp-PLA2进行Pearson相关分析,结果显示2型糖尿病患者HbA1c与Lp-PLA2呈显著正相关(r=0.33,P<0.05)。结论 Lp-PLA2参与了2型糖尿病及其并发症的发生、发展过程,定期监测相关指标对预防、治疗和减少糖尿病患者并发症的发生有着非常重要的临床意义。
Abstract:
Abstract:Objective To analysis of the relationship between Lp-PLA2 and type 2 diabetes,and to further explore the Lp-PLA2 in complications of type 2 diabetes in the occurrence and development of the role and clinical significance through the detection of serum in patients with type 2 diabetes mellitus lipoprotein associated phospholipase A2(Lp-PLA2)level.Method 189 patients with type 2 diabetes in the department of endocrinology of shaanxi people's hospital were selected and divided into 3 groups,including 49 patients with type 2 diabetes mellitus,type 2 diabetes mellitus with hyperlipidemia patients 56 cases,type 2 diabetes mellitus with atherosclerosis 84 cases.At the same time,65 cases of normal control group were selected.The levels of Lp-PLA2 and HbA1c were detected,and the results were compared among the groups.Results The levels of Lp-PLA2 in type 2 diabetes mellitus group(184.83±23.33 ng/ml),type 2 diabetes mellitus complicated with hyperlipidemia group(204.06±28.05 ng/ml),type 2 diabetes mellituscomplicated with atherosclerosis group(231.50±38.19 ng/ml)were higher thanthose in control group(88.51±21.91 ng/ml),and the difference between the four groups was statistically significant(F=194.78,P<0.01).In the simpletype 2 diabetes group.Pearson correlation analysis was performed between HbA1cand Lp-PLA2.The results showed that there was a significant positive correlation between HbA1c and Lp-PLA2 in patients with type 2 diabetes mellitus(r=0.33,P<0.05).Conclusion Lp-PLA2 is involved in theoccurrence and development of type 2 diabetes mellitus and its complications.Regular monitoring of related indicators is of great clinical significance for prevention, treatment and reduction of complications in diabetic patients.

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备注/Memo

备注/Memo:
作者简介:李 薪(1990-),女,西安医学院硕士研究生在读,专业:临床检验诊断学。 通讯作者:魏力强,主任检验技师,E-mail:wlq8399@126.com。
更新日期/Last Update: 2017-12-26