[1]白雪梅,李月玲,于培红,等.中国长寿地区中老年人群脑卒中发生率调查及其与高血压、糖尿病、心脏病的相关性分析[J].现代检验医学杂志,2018,33(01):5-9.[doi:10.3969/j.issn.1671-7414.2018.01.001]
　BAI Xue-mei,LI Yue-Ling,YU Pei-hong,et al.Incidence of Cerebral Apoplexy in the Elderly Population in Longevity Areas in China and Its Correlation with Hypertension,Diabetes and Heart Disease[J].Journal of Modern Laboratory Medicine,2018,33(01):5-9.[doi:10.3969/j.issn.1671-7414.2018.01.001]
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中国长寿地区中老年人群脑卒中发生率调查及其与高血压、糖尿病、心脏病的相关性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年01期
页码:
5-9
栏目:
论著
出版日期:
2018-02-05

文章信息/Info

Title:
Incidence of Cerebral Apoplexy in the Elderly Population in Longevity Areas in China and Its Correlation with Hypertension,Diabetes and Heart Disease
文章编号:
1671-7414(2018)01-005-05
作者:
白雪梅1; 李月玲1; 于培红1; 殷召雪2; 施小明3
1.首都医科大学,北京 100069; 2.中国疾病预防控制中心慢性病防治与社区卫生处,北京 102206; 3.中国疾病预防控制中心环境与健康相关产品安全所,北京 100020
Author(s):
BAI Xue-mei1; LI Yue-Ling1; YU Pei-hong1; YIN Zhao-xue2; SHI Xiao-ming3
1.Capital Medical University,Beijing 100069,China; 2.Division of Chronic Diseases Control and Community Health,Chinese Center for Disease Control and Prevention, Beijing 102206,China; 3.National Institute of Environmental Health,Chinese Center for Disease Control and Prevention,Beijing 100020,China
关键词:
脑卒中;  高血压;  糖尿病;  心脏病
分类号:
R743.3; R446
DOI:
10.3969/j.issn.1671-7414.2018.01.001
文献标志码:
A
摘要:
目的 研究中国长寿地区中老年人群中脑卒中发生率,及其与高血压、糖尿病、心脏病等老年人常见慢性疾病的相关性,研究已发生脑卒中受试者与未发生脑卒中受试者(且排除高血压、糖尿病、心脏病)以下常见血液生化指标的差异:超氧化物歧化酶(SOD)、丙二醛(MDA)、超敏C反应蛋白(hsCRP)、清蛋白(ALB)、葡萄糖(GLU)、胆固醇(CHO)、三酰甘油(TG)、高密度脂蛋白(HDLC)、糖化血清蛋白(GSP)、尿素氮(BUN)、肌酐(CREA)和尿酸(UA)。方法 以中国8个长寿之乡参加2014年长寿县市“老年人口健康状况的生物医学研究”的居民作为目标对象,有2 315例40岁以上受试者参加调查且留取了足量的静脉血,其中40～岁组22例,60～岁组238例,70～岁组490例,80～岁组629例,90～岁组518例,100～岁组418例。采用自行设计的调查表收集社会人口学特征等信息,由临床医生采用统一的检查工具对研究对象进行体检。空腹采集静脉血,检测SOD,MDA,hsCRP,ALB,GLU,CHO,TG,HDLC,GSP,BUN,CREA和UA。并比较不同年龄组、不同性别受试者高血压、糖尿病、心脏病、脑卒中的患病情况和上述指标在不同健康人群中的差异。结果 高血压、糖尿病、心脏病、脑卒中的患病率都随着年龄而增加,达到峰值后,又缓慢降低,达到峰值的年龄分别是90～99,60～69,70～79和80～89。脑卒中受试者与非脑卒中受试者高血压患病率分别为71.62%和60.54%,其差异有统计学意义(χ2=7.162,P=0.007); 糖尿病患病率分别为18.92%和11.35%,其差异有统计学意义(χ2=7.602,P=0.006); 心脏病的患病率分别为20.98%和5.26%,其差异有统计学意义(χ2=25.915,P=0.000); 非高血压、非糖尿病、非心脏病的比率分别为4.73%和33.41%,其差异有统计学意义(χ2=52.444,P=0.000)。已发生脑卒中受试者与未发生脑卒中受试者人群常见生物化学指标比较((-overx)±s)如下:SOD分别为55.76±8.27和57.16±8.00 U/ml,差异无统计学意义(t=0.341,P=0.053),MDA分别为5.81±3.82和5.67±3.16 μmol/L,差异无统计学意义(t=0.329,P=0.661),hsCRP分别为4.15±12.33和2.94±6.25 mg/L,差异无统计学意义(t=0.026,P=0.080); ALB分别为41.60±4.51和42.08±3.94 g/L,差异无统计学意义(t=0.032,P=0.194); GLU分别为5.89±2.67和4.90±0.90mmol/L,差异有统计学意义(t=0.000,P=0.000); CHO分别为4.81±1.00和4.71±1.02 mmol/L,差异无统计学意义(t=0.670,P=0.318); TG分别为1.33±0.69和1.14±0.57 mmol/L,差异有统计学意义(t=0.012,P=0.000); HDLC分别为1.29±0.35和1.41±0.40 mmol/L,差异有统计学意义(t=0.004,P=0.001); GSP分别为259.10±60.90和246.75±24.52 μmol/L,差异有统计学意义(t=0.000,P=0.000); BUN分别为6.84±3.53和6.62±2.20 mmol/L,差异无统计学意义(t=0.110,P=0.338); CREA分别为84.92±33.00和80.14±24.64 μmol/L,差异有统计学意义(t=0.013,P=0.044); UA分别为296.73±91.34和288.12±80.47 μmol/L,差异无统计学意义(t=0.123,P=0.247)。结论 糖尿病、高血压和心脏病是脑卒中发生的危险因素,血糖、血脂代谢异常、GLU增高、TG增高、HDLC降低是脑卒中发生的重要常见生化指标,并且脑卒中病人已有一定的肾功能损伤。
Abstract:
Abstract:Objective To study the incidence of stroke among elderly people in China's longevity area and its association with diseases such as hypertension,diabetes and heart disease.The differences in the followingcommon hematological indicators in subjects with stroke and non-hypertension,diabetes,heart disease and stroke were studied:superoxide dismutase(SOD),malondialdehyde(MDA),hypersensitive c-reactive protein(hsCRP),albumin(propagated)glucose(GLU),cholesterol(CHO),triglyceride(TG),high-density lipoprotein cholesterol(HDLC),glycosylated serum protein(GSP)urea nitrogen(BUN),creatinine(CREA)and uric acid(UA).Methods Residents whoparticipated in the project of biomedical research of aging population conducted in 2014 were selected from 8 longevity Areas in China.2 315 people aged 40 and over attended the study,including 22 aged 40 and over,238 aged 60 and over,490aged 70 and over,629 aged 80 and over,518 aged 90 and over,418 aged 100 and over.Using the self-designed questionnaire to collect information about the characteristics of social demographics,the clinical doctors used the unified inspection tool to examine the subjects.The fasting blood samples were collected byvacuum tube at early morning.The contents of plasma SOD,MDA,hsCRP,ALB,GLU,CHO,TG,HDLC,GSP,BUN,CREA and UA were detected and compared among these elderly who were classified into different genders and different age groups and different healthy groups.Results The prevalence of high blood pressure,diabetes,heart disease and stroke increased with age,reaching a peak and then slowly decreasing.The age of peak was 90～99,60～69,70～79 and 80～89.The prevalence of hypertension was 71.62% and 60.54% respectively for strokesubjects and non-cerebral apoplexy subjects,and the difference was statistically significant.The prevalence of diabetes was 18.92% and 11.35% respectively,and the difference was statistically significant.The prevalence of heart disease was 20.98% and 5.26%,respectively,and the difference was statistically significant.The rates of non-hypertension,non-diabetic and non-heart diseasewere 4.73% and 33.41% respectively,and the difference was statistically significant.In the groups of Stroke subjects and Non-high blood pressure,non-diabetic,non-heart disease subjects the following indicators were Compared,values of SOD were 55.76±8.27 and 57.16±8.00 U/ml respectively,the differencebetween groups were not statistically significant(t=0.341,P=0.053),values of MDA were 5.81±3.82 and 5.67±3.16 μmol/L respectively,the difference between groups were not statistically significant(t=0.329,P=0.661),values of hsCRP were 4.15±12.33 and 2.94±6.25 mg/L,respectively,the difference between groups were not statistically significant(t=0.026,P=0.080),values of ALB were 41.60±4.51 and 42.08±3.94 g/L respectively,the difference between groups were not statistically significant(t=0.032,P=0.194),values of ALB were 41.60±4.51 and 42.08±3.94 g/L respectively,the difference between groups were not statistically significant(t=0.032,P=0.194),values of ALB were 41.60±4.51 and 42.08±3.94 g/L respectively,the difference between groups were not statistically significant(t=0.032,P=0.194),values of GLU were 5.89±2.67 and 4.90±0.90 mmol/L respectively,the difference between groups showed statistically significant(t=0.000,P=0.000)),values of CHO were 4.81±1.00 and 4.71±1.02 mmol/L respectively,the difference between groups were not statistically significant(t=0.670,P=0.318),values of TG were1.33±0.69 and 1.14±0.57 mmol/L respectively,the difference between groups showed statistically significant(t=0.012,P=0.000),values of HDLC were 1.29±0.35 and 1.41±0.40 mmol/L respectively,the difference between groups showed statistically significant(t=0.004,P=0.001),values of GSP were 259.10±60.90 and 246.75±24.52 μmol/L respectively,the difference between groups showed statistically significant(t=0.000,P=0.000),values of BUN were 6.84±3.53 and 6.62±2.20 mmol/L respectively,the difference between groups were not statistically significant(t=0.110,P=0.338),values of CREAwere 84.92±33.00 and 80.14±24.64 μmol/L respectively,the difference between groups showed statistically significant(t=0.013,P=0.044),values ofUA were 296.73±91.34 and 288.12±80.47 μmol/L respectively,the difference between groups were not statistically significant(t=0.123,P=0.247).Conclusion Diabetes,hypertension,and heart disease arerisk factors for stroke.Abnormal blood glucose and lipid metabolism:the increase of GLU,TG and the decrease of HDLC are important common biochemical index ofstroke.Patients with cerebral apoplexy have certain renal impairment.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(71110107025,71233001,71490732,81273160)。 作者简介:白雪梅(1976-),女,医学学士,主管检验师,主要研究方向:临床化学和免疫学,E-mail:bai_xm@163.com。 通讯作者:于培红,首都医科大学临床检验中心主任,研究方向:临床化学和免疫学,E-mail:yuph@ccmu.edu.cn。 殷昭雪,中国疾病预防控制中心慢性病防治与社区卫生处,副研究员,研究方向:老年健康,E-mail: zhaoxue_y@163.com。
更新日期/Last Update: 2018-02-07