[1]秦绪珍a,王丹晨a,叶益聪b,等.血清多种生化指标在PCI患者围术期的浓度变化[J].现代检验医学杂志,2018,33(01):35-39.[doi:10.3969/j.issn.1671-7414.2018.01.001]
　QIN Xu-zhena,WANG Dan-chena,YE Yi-congsup>b,et al.Perioperative Changes of Serum Biochemical Markers in Patients with PCI[J].Journal of Modern Laboratory Medicine,2018,33(01):35-39.[doi:10.3969/j.issn.1671-7414.2018.01.001]
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血清多种生化指标在PCI患者围术期的浓度变化()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年01期
页码:
35-39
栏目:
论著
出版日期:
2018-02-05

文章信息/Info

Title:
Perioperative Changes of Serum Biochemical Markers in Patients with PCI
文章编号:
1671-7414(2018)01-035-05
作者:
秦绪珍1a; 王丹晨1a; 叶益聪1b; 唐国栋2; 侯立安1a; 刘 荔1a; 鲁 军1a;  尤婷婷1a; 李洪磊1a; 邱 玲1a
1.中国医学科学院北京协和医院 a.检验科; b.心内科,北京 100730; 2.北京医院心内科,北京 100730
Author(s):
QIN Xu-zhen1a; WANG Dan-chen1a; YE Yi-cong<sup>1b; TANG Guo-dong2; HOU Li-an1a; LIU Li1a;  LU Jun1a; YOU Ting-ting1a; LI Hong-lei1a; QIU Ling1a
1a.Department of Laboratory Medicine; 1b.Department of Cardiology,Peking Union Medical College Hospital, Chinese Academic Medical Science and Peking Union Medical College,Beijing100730,China; 2.Department of Cardiology,Beijing Hospital,Beijing 100730,China
关键词:
经皮冠状动脉介入术;  心型脂肪酸结合蛋白;  缺血修饰清蛋白;  白细胞介素;  肿瘤坏死因子;  髓过氧化物酶
分类号:
R616; R446.112
DOI:
10.3969/j.issn.1671-7414.2018.01.001
文献标志码:
A
摘要:
目的 探讨经皮冠状动脉介入治疗(percutaneous coronaryintervention,PCI)患者心型脂肪酸结合蛋白(heart-type fatty acid-binding protein, h-FABP)、缺血修饰清蛋白(ischemia modified albumin,IMA)、白细胞介素-2受体(interleukin-2 receptor,IL-2R)、白细胞介素-6(interleukin-6,IL-6)、白细胞介素-8(interleukin-8,IL-8)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、髓过氧化物酶(myeloperoxidase,MPO)等指标在术后24 h内的变化规律。方法 收集2011年11月～2012年2月北京协和医院心内监护室实施PCI术后34例患者2,4,8和24 h血清标本,分别检测IL-2R,IL-6,IL-8,TNF-α,h-FABP,IMA和MPO血清浓度。结果 MPO,h-FABP和CKMB浓度在PCI术后2h已明显升高(2 h与24 h比较,Z值分别为-3.621,-5.123,-2.789,均P<0.05),h-FABP浓度在24 h内快速降到正常范围内,MPO浓度在4 h后明显降低,CKMB浓度在4 h达峰值,然后迅速降低; CK,cTnI浓度在PCI术后4 h升高(4 h和24 h比较,Z值分别为-2.803,-2.31,均P<0.05),8 h达峰值后逐渐降低。Spearman相关分析cTnI与CKMB,CK相关系数大于0.6以上。结论 研究发现PCI术后多种生化标志物的变化规律,为临床诊治提供依据。
Abstract:
Abstract:Objective To evaluate the perioperative changes of h-FABP,IMA,IL-2R,IL-6,IL-8,TNF-α and MPO in patients with PCI.Methods The serial serum samples from 34 patients were collected from November of 2011 to February of 2012 in coronary care unit of Peking Union Hospital on separately 2,4,8 and 24 hours after PCI,then IL2R,IL6,IL8,TNF-α,h-FABP,IMA and MPO were measured.Results MPO,h-FABP and CKMB increased dramatically at 2 hours after PCI(Z value were separately -3.621,-5.123 and -2.789 compared with the level at 2 h and 24h,all P<0.05),and h-FABP within 24 hours fell into the normal range.MPOdropped quickly after 4 hours of surgery and CKMB peaked at 4 hours,then decreased.The concentration of CK and cTnI rose up at 4h(Z value were separately -2.803 and -2.31 compared with the level at 2h and 24 h,all P<0.05)and declined with a climax at 8h after PCI.The correlation coefficient of CKMB and CK with cTnI were higher than 0.6.Conclusion This study provided an overview of the change of multi-biomarkers following PCI,which gave avaluable information for clinical treatment.

参考文献/References:

[1] Lo N,Michael T,Moin D,et al.Periprocedural myocardial injuryin chronic total occlusion percutaneous interventions:a systematic cardiac biomarker evaluation study[J].JACC Cardiovasc Interv,2014,7(1):47-54.
[2] Levine GN,Bates ER,Blankenship JC,et al.2011 ACCF/AHA/SCAI guidelinefor percutaneous coronary intervention:a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions[J].Circulation,2011,124(23):e574-651.
[3] Ahmad T,Fluzat M,Felker GM,et al.Novel biomarkers in chronic heart failure[J].Nat Rev Cardiol,2012,9(6):347-359.
[4] 王继贵.急性冠脉综合征生化标志物研究的现代进展[J].现代检验医学杂志,2012,27(3):1-5,9. Wang JG.Modern progress of research on biochemical markers in acutecoronary syndrome[J].Journal of Modern Laboratory Medicine,2012,27(3):1-5,9.
[5] Al-Hadi HA,Fox KA.Cardiac markers in the early diagnosis and management of patients with acute coronary syndrome[J].Sultan Qaboos University Medical Journal,2009,9(3):231-246.
[6] Brennan ML,Penn MS,Van Lente F,et al.Prognostic value of myeloperoxidase in patients with chest pain[J].N Engl J Med,2003,349(17):1595-1604.
[7] Pang Z,Zhao W,Yao Z.Cardioprotective effects of nicorandil on coronaryheart disease patients undergoing elective percutaneous coronary intervention[J].Med Sci Monit,2017,23:2924-2930.
[8] 胡道军,郁 淼,张洪磊,等.基于logistics回归和ROC曲线综合评价IMA,NLR,hsCRP和CKMB联合检测对早期急性心肌梗死的诊断价值[J].现代检验医学杂志,2016,31(5):76-80. Hu DJ,Yu M,Zhang HL,et al.Comprehensive evaluation of the diagnostic value of the combined detection of IMA,NLR,hs-CRP and CK-MB for acute myocardial infarction based on ROC curve and logistic regression analysis[J].Journal of Modern Laboratory Medicine,2016,31(5):76-80.
[9] 肖路延,王 萌,唐志毅,等.缺血修饰清蛋白在急性冠状动脉综合征早期诊断中的临床意义[J].现代检验医学杂志,2009,24(3):154-157. Xiao LY,Wang M,Tang ZY,et al.Clinical significance of ischemia modified albumin in early diagnosis of acute coronary syndromes[J].Journal ofModern Laboratory Medicine,2009,24(3):154-157.
[10] Andrié RP,Becher UM,Frommold R,et al.Interleukin-6 is thestrongest predictor of 30-day mortality in patients with cardiogenic shock dueto myocardial infarction[J].Critical Care,2012,16:R152.
[11] Frangogiannis NG.The inflammatory response in m-yocardial injury,repair and remodeling[J].Nature Reviews Cardiology,2014,11(5):255-265.
[12] 梁 瀛,王新宇,牛 杰,等.急性心肌梗死患者血清炎症因子的动态变化及相互关系[J].中华医学杂志,2011,91(12):819-823. Liang Y,Wang XY,Niu J,et al.Temporal changes and interaction of serum cytokines in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention[J].National Medical Journal of China,2011,91(12):819-823.
[13] Nursalim A,Suryaatmadja M,Panggabean M.Potential clinical applicationof novel cardiac biomarkers for acute myocardial infarction[J].Acta Med Indones,2013,45(3):240-250.
[14] 喻红波,刘 阳,罗俊卿,等.髓过氧化物酶在非ST段抬高急性冠状动脉综合征诊断和预后中的临床应用[J].现代检验医学杂志,2015,30(3):77-79. Yu HB,Liu Y,Luo JQ,et al.Clinical application of myeloperoxidase in diagnosis and prognosis of Non-ST elevation acute cornary syndromes[J].Journalof Modern Laboratory Medicine,2015,30(3):77-79.
[15] Singh TP,Nigam AK,Gupta AK,et al.Cardiac biomarkers:when to test?-physician perspective[J].Journal Indian Academy of Clinical Medicine,2011,12(2):117-121. 收稿日期:2017-10-24 修回日期:2017-12-07

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备注/Memo

备注/Memo:
基金项目:863计划心脑血管慢性损伤及急救指标等体外诊断试剂的研制(2011AA02A111)。 作者简介:秦绪珍(1980-),女,硕士,副主任医师,主要从事心血管流行病学和肿瘤免疫研究,E-mail:qxz_01@163.com。 通讯作者:邱 玲,女,研究员,E-mail:lingqiubj@aliyun.com。
更新日期/Last Update: 2018-02-07