[1]张 梅,李林娟,冯旭霞a,等.T2DM并发NAFLD患者血清Nesfatin-1水平变化及相关影响研究[J].现代检验医学杂志,2018,33(01):77-80，85.[doi:10.3969/j.issn.1671-7414.2018.01.001]
　ZHANG Mei,LI Lin-juan,FENG Xu-xiaa,et al.Analysis of T2DM to the Serum Nesfatin-1 Level Changes of Patients with NAFLD Horizontal[J].Journal of Modern Laboratory Medicine,2018,33(01):77-80，85.[doi:10.3969/j.issn.1671-7414.2018.01.001]
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T2DM并发NAFLD患者血清Nesfatin-1水平变化及相关影响研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年01期
页码:
77-80，85
栏目:
论著
出版日期:
2018-02-05

文章信息/Info

Title:
Analysis of T2DM to the Serum Nesfatin-1 Level Changes of Patients with NAFLD Horizontal
文章编号:
1671-7414(2018)01-077-05
作者:
张 梅1; 李林娟1; 冯旭霞2a; 李 亚1; 薛亚妮2b
1.延安大学附属医院东关分院综合内科,陕西延安 716000; 2.延安大学附属医院 a.CT/MR诊断科; b.呼吸内科,陕西延安 716000
Author(s):
ZHANG Mei1; LI Lin-juan1; FENG Xu-xia2a; LI Ya1; XUE Ya-ni2b
1.Dongguan Branch of Affiliated Hospital of Yan'an University,Shaanxi Yan'an 716000,China; 2a.CT/MR Diagnostic Department; 2b.Department of Respiratory Medicine,Affiliated Hospital of Yan'an University,Shaanxi Yan'an 716000,China
关键词:
血清Nesfatin-1;  2型糖尿病;  非酒精性脂肪肝
分类号:
R587.1; R575.5
DOI:
10.3969/j.issn.1671-7414.2018.01.001
文献标志码:
A
摘要:
目的 研究2型糖尿病并发非酒精性脂肪肝(Nonalcoholic fatty liver disease,NAFLD)患者血清Nesfatin-1水平变化及相关影响,为阐明其生理作用提供可靠依据。方法 选取2014年1月～2016年1月延安大学附属医院内分泌科收治的2型糖尿病患者300例作为研究对象,根据患者是否并发NAFLD将其分为T2DM伴有NAFLD组150例与T2DM不伴有NAFLD组150例,另外选取同期在医院进行健康体检的150例志愿者作为对照组,比较三组患者的血清Nesfatin-1水平和相关生化指标,并监测两组2型糖尿病患者的胰岛素对抗指数。结果 BMI(kg/m2),TG(mmol/L),ALT(mmol/L)和INS(mIU/L)指标对比结果为:T2DM组(分别为22.1±2.5,2.0±0.9,22.1±10.5和11.2±4.5)和NGT组(分别为23.1±1.9,1.7±0.5,26.9±12.7和9.7±2.4)显著低于T2DM-NAFLD组(分别为26.5±3.8,3.0±2.5,31.9±11.5和14.2±6.5,P值均为0.00)。FBG(mmol/L),HbAlc(%),LDL-C(mmol/L),HOMA-IR和血清Nesfatin-1(ng/ml)指标对比结果为:T2DM组(分别为8.4±3.1,8.8±2.7,3.4±1.0,4.5±2.9和6.9±3.0)和T2DM-NAFLD组(分别为8.2±2.7,8.5±1.9,3.7±2.1,5.2±2.7和5.2±2.7)显著高于NGT组(分别为5.1±0.5,5.4±0.4,2.7±0.8,2.7±0.8和2.3±0.7,P值均为0.00)。Pearson分析发现T2DM组患者与T2DM-NAFLD组患者的血清Nesfatin-1水平呈现中度相关性(r=-0.421,P<0.05)。BMI,TG和血清Nesfatin-1水平与脂肪肝的发生有密切的联系(r=-0.402～-0.273,P=0.00～0.01)。结论 血清Nesfatin-1可能参与2型糖尿病与NAFLD的发生。
Abstract:
Abstract:Objective To study the effects of theserum Nesfatin-1 level change by type 2 diabetes in patients withNon-alcoholic fatty liver,and provides a reliable basis for its prysiologicaleffects.Methods Selected 300 cases with type 2 diabetesmellitus in deoartment of endocrinology from January 2014 to January 2016 inAffiliated Hospital of Yan'an University as the object of this study.Accordingto whether the patients were combined with non-alcoholic fatty liver,the patientswere divided into T2DM with NAFLD group(150 cases)and T2DM without NAFLD group(150 cases).In addition,150 volunteers for healthy check-up in the hospital were selected as control group.Compared the serum Nesfatin-1 levels of three group patients,and monitored the insulin resistance index of two groups patients with type 2 diabetes.Results BMI,TG,ALT and INS of NGT(23.1±1.9,1.7±0.5,26.9±12.7 and 9.7±2.4,respectively)group andT2DM(22.1±2.5,2.0±0.9,22.1±10.5 and 11.2±4.5,respectively)group were significantly lower than those of T2DM-NAFLD group(26.5±3.8,3.0±2.5,31.9±11.5 and 14.2±6.5; all P value were 0.00).FBG,HbAlc,LDL-C,HOMA-IR and Nesfatin-1 of T2DM group(8.4±3.1,8.8±2.7,3.4±1.0,4.5±2.9 and 6.9±3.0)and T2DM-NAFLD group(8.2±2.7,8.5±1.9,3.7±2.1,5.2±2.7 and 5.2±2.7)were significantly higher than those in serumNGT group(5.1±0.5,5.4±0.4,2.7±0.8,2.7±0.8 and 2.3±0.7,allP value were 0.00).The serum Nesfatin-1 levels of T2DM patients and patients with T2DM-NAFLD had moderate correlation(r=-0.421,P<0.05)by Pearson correlation analysis.BMI,TG and serum Nesfatin-1 levels were closely associated with the occurrence of fatty liver(r=-0.402～-0.273; P=0.00～0.01).Conclusion Nesfatin-1 may be involved in type 2 diabetes mellitus and the occurrence of non-alcoholic fatty liver.

参考文献/References:

[1] 皇甫竞坤,闫 杰,王艳斌,等.血清脂联素水平与非酒精性脂肪性肝病相关性研究[J].中华临床医师杂志(电子版),2013,7(7):2852-2855. Huangfu JK,Yan J,Wang YB,et al.The relationship between serum adiponectin and nonalcoholic fatty liver disease[J].Chinese Journal of Clinicians(Electronic Edition),2013,7(7):2852-2855.
[2] Arslan N,Sayin O,Tokgoz Y.Evaluation of serum xenin and ghrelin levelsand their relationship with nonalcoholic fatty liver disease and insulin resistance in obese adolescents[J].Journal of Endocrinological Investigation,2014,37(11):1091-1097.
[3] Cohen RI,Ginsberg N,Tsang D,et al.Association of nesfatin-1 and fatmass in cystic fibrosis[J].Respiration:International Review of Thoracic Diseases,2013,86(4):312-317.
[4] 卢东晖,张 帆,连晓芬.2型糖尿病伴非酒精性脂肪肝患者血清nesfatin-1水平的变化[J].重庆医学,2015,44(24):3350-3351,3354. Lu DH,Zhang F,Lian XF.Change of serum nesfatin-1 levels in type2 diabetes patients with non-alcoholic fatty liver[J].Chongqing Medicine,2015,44(24):3350-3351,3354.
[5] 郭 伟,高明松,李 阳,等.不同糖耐量状态下非酒精性脂肪肝病患者血清Nesfatin-1水平的比较及相关因素的研究[J].中国现代医学杂志,2015,25(24):45-48. Guo W,Gao MS,Li Y,et al.Serum Nesfatin-1 levels and related factors in different glucose tolerance individuals with nonalcoholic fatty liver disease[J].China Journal of Modern Medicine,2015,25(24):45-48.
[6] 刘云涛,简 磊,李建伟,等.糖代谢及胰岛素抵抗改善对2型糖尿病患者血清nesfatin-1水平的影响[J].重庆医学,2014,43(13):1624-1626. Liu YT,Jian L,Li JW,et al.Glucose metabolism and insulin resistance improving effect on serum nesfatin-1 level in patients with type 2 diabetes[J].Chongqing Medicine,2014,43(13):1624-1626.
[7] 刘云涛,黄 亮,胡 斌,等.不同糖耐量人群血清nesfatin-1水平及相关因素分析[J].国际内分泌代谢杂志,2013,33(1):4-7. Liu YT,Huang L,Hu B,et al.The correlation of serum nesfatin-1 levels in individuals with different glucose tolerance[J].International Journal of Endocrine and Metabolism,2013,33(1):4-7.
[8] 高辽梅,张 勇,王 东,等.2型糖尿病患者短期胰岛素强化治疗前后血清nesfatin-1水平的变化[J].医学研究杂志,2015,44(5):114-117.Gao LM,Zhang Y,Wang D,et al.Changes of serum nesfatin-1 levels in type 2 diabetic patients by short-term intensive insulin treatment[J].Journal of Medical Research,2015,44(5):114-117.
[9] 宋 燕,邵冬华,何美琳,等.PNPLA3基因多态性与非酒精性脂肪性肝病关系的初步探讨[J].现代检验医学杂志,2016,31(4):5-9. Song Y,Shao DH,He ML,et al.Preliminary discussion of the relationship between PNPLA3 polymorphism and NAFLD[J].Journal of Modern Laboratory Medicine,2016,31(4):5-9.
[10] 于正清,李 礼,胡娟玉,等.2型糖尿病患者血清CA199与HbA1c的相关性研究[J].现代检验医学杂志,2013,28(3):114-116. Yu ZQ,Li L,Hu JY,et al.Correlation between CA 199 and HbA1c in patients with type 2 diabetes millotues[J].Journal of Modern Laboratory Medicine,2013,28(3):114-116.
[11] 顾光大.血清nesfatin-1在2型糖尿病合并冠心病中的诊断意义[J].心脑血管病防治,2014,14(2):132-134. Gu GD.Significance of serum nesfatin-1 in the diagnosis of type 2 diabetes complicated with coronary heart disease[J].Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases,2014,14(2):132-134.
[12] 郭 伟,高明松,彭 聪,等.血清nesfatin-1与非酒精性脂肪性肝病的相关性研究[J].胃肠病学和肝病学杂志,2015,24(4):444-446. Guo W,Gao MS,Peng C,et al.The association between serum nesfatin-1 and nonalcoholic fatty liver disease[J].Chinese Journal of Gastroenterology andHepatology,2015,24(4):444-446.
[13] Varricchio E,Russolillo MG,Russo F,et al.Expression and immuno histochemical detection of Nesfatin-1 in the gastrointestinal tract of Casertana pig[J].Acta Histochemica,2014,116(4):583-587.
[14] Ohl S,Shimizu H,Staoh T,et al.Identification of ne-sfatin-1 as a satiety molecule in the hypotalamus[J].Nature,2006,443(7112):709-712.
[15] Basar O,Akbal E,Koklu S,et al.A nonvel appetide,nesfatin-1 in patients with non-atcohplic fatty liver disease[J].Scand J Clin Lab Invest,2012,72(6):479-483. 收稿日期:2016-10-10 修回日期:2017-11-10

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备注/Memo

备注/Memo:
基金项目:陕西省教育厅自然科学研究项目,编号:2013JK0781。 作者简介:张 梅(1985-),女,硕士,主治医师,研究方向:非酒精性脂肪肝并发2型糖尿病相关研究,E-mail:zhangmei6a@163.com。 通讯作者:薛亚妮,女,主治医师,E-mail:153157625@qq.com。
更新日期/Last Update: 2018-02-07