[1]杜伟平,米思蓉,王 丽,等.延安地区妇女HPV基因分型及临床相关研究[J].现代检验医学杂志,2018,33(01):109-111,114.[doi:10.3969/j.issn.1671-7414.2018.01.001]
　DU Wei-ping,MI Si-rong,WANG Li,et al.HPV Genotyping and Clinical Studies of Women in Yan'an Area[J].Journal of Modern Laboratory Medicine,2018,33(01):109-111,114.[doi:10.3969/j.issn.1671-7414.2018.01.001]
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延安地区妇女HPV基因分型及临床相关研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年01期
页码:
109-111,114
栏目:
论著
出版日期:
2018-02-05

文章信息/Info

Title:
HPV Genotyping and Clinical Studies of Women in Yan'an Area
文章编号:
1671-7414(2018)01-109-04
作者:
杜伟平; 米思蓉; 王 丽; 张宁梅; 呼志西; 李芳芹
延安大学附属医院,陕西延安 716000
Author(s):
DU Wei-ping; MI Si-rong; WANG Li; ZHANG Ning-mei; HUZhi-xi; LI Fang-qin
Affiliated Hospital of Yan'an University,Shaanxi Yan'an 716000,China
关键词:
HPV基因分型;  临床特点;  宫颈疾病
分类号:
R373; Q781
DOI:
10.3969/j.issn.1671-7414.2018.01.001
文献标志码:
A
摘要:
目的 对比分析延安市妇女人乳头瘤病毒(HPV)感染的基因型分布情况和临床特点,为宫颈癌筛查和防治提供数据支持。方法 采用导流杂交法对HPV感染型别进行基因分型,统计临床感染分布数据,并对其结果进行对比分析。结果 2 014例妇女中共检出HPV阳性者332例,阳性率16.48%,HPV高危型中HPV-16,52和53居于前三位,HPV低危型以HPV-81,6和44为主。阳性标本中单纯高危型感染219例,单纯低危型感染74例,混合感染39例,构成比分别为65.96%,22.29%和11.75%。HPV感染率随年龄增长呈现先增长后下降的趋势,各组比较差异有统计学意义(χ2=34.238,P<0.01)。不同职业人群HPV阳性检出率不同,各组比较差异有统计学意义(χ2=50.35,P<0.01)。不同地域人群HPV阳性检出率也存在差异,各组比较差异有统计学意义(χ2=12.084,P<0.05)。HPV感染结果中单一感染占比最高。结论 HPV感染率在不同人群、地域、年龄存在差异,进行HPV筛查对于宫颈癌的早期预防和治疗具有重要的意义。
Abstract:
Abstract:Objective To contrast HPV genotyping and clinical characteristics of women in Yan'an and provide data support for cervical cancer screening and prevention.Methods The genotypingof HPV infection was carried out by the method of PCR amplification and reversehybridization.To statistical analysis clinical infection distribution data.Results Found 16.48%(332 of 2014)were positive for HPV DNA in these women.HPV-16,52 and 53 were in the top three HPV high-risk types.HPV- 81,6 and 44 were in the top three HPV low-risk types.There were 219 cases(65.96%)with pure high-risk type infection,74 cases(22.29%)with pure low-risk type infection and 39 cases(11.75%)with mixed infection in positive specimens.The HPV infection rate had showed first increasing then decreasingwith age,and there were significant differences among the each groups(χ2=34.238,P<0.01).There were also differences in HPV positive detection rates in different occupations and there were significant differences among the each groups(χ2=50.35,P<0.01).There were also differences in HPV positive detection rates in different regions,and there were significant differences among the each groups(χ2=12.084,P<0.05).Single infection was highest inHPV infection.Conclusion HPV infection was different indifferent populations,regions and ages,and it is of great significance to carry out HPV screening for early prevention and treatment of cervical cancer.

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备注/Memo

备注/Memo:
基金项目:延安市科技惠民计划,项目编号:2014HM-08。 作者简介:杜伟平(1985-),男,硕士在读,主管检验师,研究方向:病毒DNA,基因多态性,E-mail:724411083@qq.com。 通讯作者:李芳芹(1963-),女,本科,主任检验师,研究方向:病原微生物的快速检验。
更新日期/Last Update: 2018-02-07