[1]徐金良a,杜丹丹,翟志敏,等.卵巢良恶性肿瘤患者血液NLR,LMR,RDW,PLR四项参数的变化及其临床意义[J].现代检验医学杂志,2018,33(02):16-18,22.[doi:10.3969/j.issn.1671-7414.2018.02.001]
　XU Jin-lianga,DU Dan-dan,ZHAI Zhi-min,et al.Changes and Clinical Significance of Four Parameters of NLR,LMR, RDW and PLR in Patients with Benign and Malignant Ovarian Tumors[J].Journal of Modern Laboratory Medicine,2018,33(02):16-18,22.[doi:10.3969/j.issn.1671-7414.2018.02.001]
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卵巢良恶性肿瘤患者血液NLR,LMR,RDW,PLR四项参数的变化及其临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年02期
页码:
16-18,22
栏目:
论著
出版日期:
2018-04-05

文章信息/Info

Title:
Changes and Clinical Significance of Four Parameters of NLR,LMR, RDW and PLR in Patients with Benign and Malignant Ovarian Tumors
文章编号:
1671-7414(2018)02-016-04
作者:
徐金良1a; 杜丹丹2; 翟志敏3; 郭进京1b
1.安徽医科大学附属阜阳市人民医院a.妇产科; b.检验科,安徽阜阳236000; 2.阜阳市第二人民医院心内科,安徽阜阳 236000; 3.安徽医科大学第二附属医院血液内科,合肥 230061
Author(s):
XU Jin-liang1a; DU Dan-dan2; ZHAI Zhi-min3; GUO Jin-jing1b
1a.Department of Obstetrics and Gynecology; 1b.Department of Clinical Laboratory,the Fuyang People's Hospital Affiliated to Anhui Medical University,Anhui Fuyang 236400,China; 2.Department ofCardiology, Fuyang Second People's Hospital,Anhui Fuyang 236400,China; 3.Department of Hematology,the Second Hospital Affiliated to Anhui Medical University,Hefei 230061,China
关键词:
卵巢癌;  中性粒细胞和淋巴细胞比值;  淋巴细胞和单核细胞比值;  血小板和淋巴细胞比值;  红细胞分布宽度
分类号:
R737.31; R730.43
DOI:
10.3969/j.issn.1671-7414.2018.02.001
文献标志码:
A
摘要:
目的 探讨卵巢癌患者术前血常规部分参数的变化意义。方法 以29例卵巢癌和30例卵巢良性肿瘤患者为研究对象,计算得出中性粒细胞与淋巴细胞比值(NLR),淋巴细胞和单核细胞比值(LMR),红细胞分布宽度(RDW),血小板和淋巴细胞比值(PLR)和CA-125水平; 依据病理对卵巢癌患者临床分期,分析NLR,LMR,RDW,PLR及CA-125水平在不同分期中的差异; 以是否为卵巢癌分组,对上述参数绘制ROC 曲线。结果 实验组和对照组NLR,LMR,RDW,PLR和CA-125水平分别为2.49±1.04 vs 1.46±0.45,4.48±1.56 vs 6.67±1.87,175.35±62.86 vs 127.11±41.99,(12.98±0.98)% vs(12.48±0.76)%,(355.9±369.73)U/ml vs(12.87±6.91)U/ml,差异均具有统计学意义(t=4.979,4.879,3.477,2.188,5.082,均P<0.05); 卵巢癌患者Ⅰ+Ⅱ期与Ⅲ+Ⅳ期上述各项参数比较差异均有统计学意义(t=3.379,2.740,3.855,2.940,3.226,均P<0.05); NLR,LMR,RDW,PLR四参数及血清CA-125水平受试者工作特征曲线法判断卵巢癌的ROC曲线下面积分别为0.874,0.823,0.749,0.680和0.905。结论 部分血常规参数可辅助诊断良恶性卵巢肿瘤,且在卵巢癌临床分期的判断中有积极的意义。
Abstract:
Abstract:Objective To explore the changes of preoperative blood parameters of ovarian cancer patients.Methods The population that we studied consisted of 29 patients with ovarian cancer and 30cases of ovarian benign tumors controls,calculated neutrophils and lymphocytesratio(NLR),lymphocytes and monocytes ratio(LMR),red blood cell distributionwidth(RDW),platelet and lymphocyte ratio(PLR)and CA-125 levels.Accordingto the clinical stage of ovarian cancer patients,the differences of NLR,LMR,RDW,PLR and CA-125 were analyzed in different stages.The above parameters wereused to draw the ROC curve for ovarian cancer.Results The average NLR,LMR,RDW,PLR and CA-125 value in experimental and controlled were 2.49±1.04 vs 1.46±0.45,4.48±1.56 vs 6.67±1.87,175.35±62.86vs 127.11±41.99,(12.98±0.98)% vs(12.48±0.76)% and(355.9±369.73)U/ml vs(12.87±6.91)U/ml respectively.The differences were statistically significant(t=4.979,4.879,3.477,2.188,5.082,all P<0.05).(Ⅰ+Ⅱ)stage and(Ⅲ+Ⅳ)stage of ovarian cancer patients in the above-mentioned parameters mean differences were statistically significant(t=3.379,2.740,3.855,2.940,3.226,all P<0.05).The area under ROC of NLR,LMR,RDW,PLR and CA-125 value in diagnosing ovarian cancer were 0.874,0.823,0.749,0.680 and 0.905 respectively.Conclusion Some blood routine parameters can be used to identify benign and malignant ovarian tumors,and have positive significance in the clinical staging of ovarian cancer.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81670179)。 作者简介:徐金良(1982-),男,主治医师,主要从事妇产科学研究,E-mail:13965583579@163.com。 通讯作者:郭进京(1982-),男,硕士,副主任检验师,E-mail:969521266@qq.com。
更新日期/Last Update: 2018-04-16