[1]冯 杰,于 帆,高艳红,等.乙状结肠癌患者血脂水平变化及其诊断价值探究[J].现代检验医学杂志,2018,33(03):74-78.[doi:10.3969/j.issn.1671-7414.2018.03.019]
　FENG Jie,YU Fan,GAO Yan-hong,et al.Invesgation of the Serum Lipids Level Changes and Its' Diagnostic Value in Sigmoid Colon Cancer[J].Journal of Modern Laboratory Medicine,2018,33(03):74-78.[doi:10.3969/j.issn.1671-7414.2018.03.019]
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乙状结肠癌患者血脂水平变化及其诊断价值探究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年03期
页码:
74-78
栏目:
论著
出版日期:
2018-07-17

文章信息/Info

Title:
Invesgation of the Serum Lipids Level Changes and Its' Diagnostic Value in Sigmoid Colon Cancer
文章编号:
1671-7414(2018)03-074-05
作者:
冯 杰1; 于 帆2; 高艳红1; 王 坤1; 颜光涛1
1.解放军总医院医学检验中心,北京 100853; 2.湘雅医学院医学检验系,长沙 410078
Author(s):
FENG Jie1; YU Fan2; GAO Yan-hong1; WANG Kun1; YAN Guang-tao1
1.Laboratory Medicine Center,PLA General Hospital,Beijing 100853,China; 2.Department of Laboratory Medicine, Xiangya School of Medicine,Central South University,Changsha 410078,China
关键词:
乙状结肠癌;  乙状结肠息肉;  血脂
分类号:
R735.35; R730.43
DOI:
10.3969/j.issn.1671-7414.2018.03.019
文献标志码:
A
摘要:
目的 分析乙状结肠癌患者血脂相关指标的变化,探讨指标对该病的临床意义和诊断价值。方法 收集2014年1月～2017年6月在解放军总医院手术治疗的乙状结肠癌患者118例、乙状结肠息肉92例和健康对照344例的临床资料,对患者基本信息及血脂相关指标进行统计分析。结果 单因素统计分析显示乙状结肠癌患者的总胆固醇(TC)、总三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、磷脂(PL)、载脂蛋白AⅠ(ApoAⅠ)、载脂蛋白AⅡ(ApoⅡ)和载脂蛋白C-III(ApoC-III)含量显著低于乙状结肠息肉组与正常对照组(F=14.68,8.49,15.18,24.82,6.72,20.95,35.54,均P<0.05); 乙状结肠癌患者血清脂蛋白(a)[Lp(a)]、载脂蛋白B(ApoB)则高于其他两组(F=24.07,2.52,P<0.05); TC+ApoB组合对乙状结肠癌的诊断较优,ROC曲线下面积(AUC)=0.77, 95% CI:0.70～0.83,敏感度为70.3%,特异度为72.8%,其二分类Logistic回归模型对乙状结肠癌的诊断准确度为71.9%。结论 血清总胆固醇和ApoB是较为理想的血液检测指标组合,有助于乙状结肠癌的早期筛查。
Abstract:
Abstract:Objective To analyze the lipid level changes, as well as to investigate the diagnostic value of these biomarkers in sigmoid colon cancer.Methods Clinical data of 118 patients with sigmoid colon cancer who underwent operation,92 patients with sigmoid polyp and 334 normal controls in Chinese PLA General Hospital from January 2014 to June2017 were retrospectively analyzed.Results Univariate analysis showed that the levels of TC,TG,HDL-C,PL,ApoAⅠ,ApoAⅡ and ApoC-III in sigmoid colon cancer group were significantly lower than other groups(F=14.68,8.49,15.18,24.82,6.72,20.95,35.54,all P<0.05),whileits levels of Lp(a)and ApoB were significantly higher(F=24.07,2.52,P<0.05).The combined TC+ApoB was the optimal(70.3% sensitivity and 72.8% specificity,AUC=0.77,95% CI:0.70～0.83).The diagnostic accuracy of the binaryLogisctic analysis model for sigmoid colon cancer was 71.9%.Conclusion The combination of TC and ApoB is more suitable as a diagnosticmodel for the screening of sigmoid colon cancer.

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备注/Memo

备注/Memo:
基金项目:国家科技支撑计划项目(2015BAK45B01)。 作者简介:冯 杰(1988-),男,硕士,主要从事医学检验工作及研究,E-mail:fengjie654321@126.com。 通讯作者:颜光涛(1960-),男,主任,教授,博士生导师,E-mail:yan301@263.net。
更新日期/Last Update: 2018-04-16