[1]曾玉萍,杨 培,郭 雪,等.基于个体内生物学变异评估同一样本系列复测值差异的方法[J].现代检验医学杂志,2018,33(03):103-107,111.[doi:10.3969/j.issn.1671-7414.2018.03.026]
　ZENG Yu-ping,YANG Pei,GUO Xue,et al.Method to Evaluate the Differences between Repeat Measurements of the Same Sample Based on Within-Subject Biological Variation[J].Journal of Modern Laboratory Medicine,2018,33(03):103-107,111.[doi:10.3969/j.issn.1671-7414.2018.03.026]
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基于个体内生物学变异评估同一样本系列复测值差异的方法()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年03期
页码:
103-107,111
栏目:
论著
出版日期:
2018-07-17

文章信息/Info

Title:
Method to Evaluate the Differences between Repeat Measurements of the Same Sample Based on Within-Subject Biological Variation
文章编号:
1671-7414(2018)03-103-06
作者:
曾玉萍1; 杨 培2; 郭 雪1; 郭锐锐1; 杨 岚1; 黄亨建2
1.四川大学华西临床医学院 医学检验系,成都 610041; 2.四川大学华西医院实验医学科,成都 610041
Author(s):
ZENG Yu-ping1; YANG Pei2; GUO Xue1; GUO Rui-rui1; YANG Lan1; HUANG Heng-jian2
1.Medical Laboratory Technology,West China Clinical Medical College of Sichuan University,Chengdu 610041,China; 2.Department of Laboratory Medicine, West China Hospital of Sichuan University,Chengdu 610041,China
关键词:
生物学变异;  参考改变值;  临界差异
分类号:
R446
DOI:
10.3969/j.issn.1671-7414.2018.03.026
文献标志码:
A
摘要:
目的 基于生物学变异评估同一样本系列复测结果可接受的临界差异(critical difference,CD)。方法 通过参考改变值(reference change value,RCV)公式转化为CD公式,分别计算95%和99%概率下同一台仪器上复测和不同仪器上复测的CDs(critical difference,same instrument)和CDD(critical difference,different instrument),建立CD与个体内生物学变异(within-subject biological variation,CVI)的关系,评估实验室生化、激素、血细胞检测以及肿瘤标志物等检测项目分别于95%和99%概率下相同和不同仪器的最优、期望及最低质量规范的CD,判断同一样本系列复测值差异的可接受性。结果 CDs在最优、期望和最低质量规范下对应CVI的系数分别为0.7,1.4和2.1(P=95%); 0.9,1.8和2.7(P=99%); CDD在最优、期望和最低质量规范下对应CVI的系数分别为0.8,1.7和2.8(P=95%); 1.0,2.3和3.6(P=99%)。结论 基于CVI评估同一样本系列复测值CD的方法计算简单,实用性强,为检验工作人员提供了又一新量化的判断标准。
Abstract:
Abstract:Objective To evaluate critical differences(CD)in a series of results of the same sample based on biological variation.Methods Converted the formula of reference difference value(RCV)into CD,and calculate CD between repeat measurements on the same instrumentand different instruments as CDs(critical difference,same instrument)and CDD(critical difference,different instrument)under 95% and 99% probability,respectively.Then the relationship between CD and within-subject biological variation(CVI)was established.Calculated CDs and CDD of the optimal,expected and minimum quality specifications for the detection of biochemistry,hormones,blood routine and tumor markers at 95% and 99% probability and determinedthe acceptability of differences between repeat measurements.ResultsCorresponding to the optimal,expected and minimum quality specifications,the coefficients of CVI were 0.7,1.4,2.1(P=95%)and 0.9,1.8,2.7(P=99%)for CDs,the coefficients of CVI were 0.8,1.7,2.8(P=95%)and 1.0,2.3,3.6(P=99%)for CDD. Conclusion The method of assessing CD of the same sample based on CVI is simple and practicable,which provides another quantitative criteria forlaboratory staff.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:四川省科技厅项目(2017SZ0063和2014SZ0170)。 作者简介:曾玉萍(1996-),女,大学本科,E-mail:2846226087@qq.com。 通讯作者:黄亨建,男,副主任技师,E-mail:huanghenjian@sina.com。
更新日期/Last Update: 2018-04-16