[1]周 颖,常 瑜,王 一.三阴乳腺癌患者血清维生素D水平与T细胞免疫功能关系的研究[J].现代检验医学杂志,2018,33(04):47-50.[doi:10.3969/j.issn.1671-7414.2018.04.012]
　ZHOU Ying,CHANG Yu,WANG Yi.Relationship between Serum Vitamin D and T Cell Immunodeficiency in Patients with Triple-Negative Breast Cancer[J].Journal of Modern Laboratory Medicine,2018,33(04):47-50.[doi:10.3969/j.issn.1671-7414.2018.04.012]
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三阴乳腺癌患者血清维生素D水平与T细胞免疫功能关系的研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年04期
页码:
47-50
栏目:
论著
出版日期:
2018-08-30

文章信息/Info

Title:
Relationship between Serum Vitamin D and T Cell Immunodeficiency in Patients with Triple-Negative Breast Cancer
文章编号:
1671-7414(2018)04-047-04
作者:
周 颖1; 常 瑜1; 王 一2
1.唐山市丰润区人民医院科教科,河北唐山 063000; 2.唐山市人民医院肿瘤外科,河北唐山 063000
Author(s):
ZHOU Ying1; CHANG Yu1; WANG Yi2
1.Science and Education,Fengrun District People's Hospital ofTangshan,Hebei Tangshan, 063000,China; 2.Tumors Surgery,Tangshan People's Hospital,Hebei Tangshan 063000,China
关键词:
三阴乳腺癌;  维生素D;  免疫功能
分类号:
R737.9; R730.43
DOI:
10.3969/j.issn.1671-7414.2018.04.012
文献标志码:
A
摘要:
目的 探讨三阴乳腺癌(TNBC)患者血清维生素D(VitD)水平与T细胞免疫功能的关系。方法 选取2015年11月～2017年11月在唐山市丰润区人民医院诊治的153例T细胞免疫功能低下(CD+4/CD8+<1.4)TNBC患者为观察组,选择153例T细胞免疫功能正常(CD+4/CD8+≥1.4)的TNBC患者为对照组。采用自行设计的调查表收集患者病历资料信息,采用ELISA法测定血清VitD水平。应用Logistic回归模型分析VitD与TNBC患者T细胞免疫功能的关系,受试者工作特征曲线(ROC)评价VitD对TNBC患者T细胞免疫功能低下诊断的灵敏度和特异度。结果 观察组血清VitD(ng/ml)水平显著低于对照组(24.38±9.72 vs 31.12±14.42),差异有统计学意义(t=2.52,P=0.00)。观察组血清VitD缺乏比例高于对照组(62.7% vs 39.2%,χ2=16.02,P=0.00)。Logistic回归分析显示,血清VitD水平降低是TNBC患者T细胞免疫功能低下的独立危险因素[OR(95%CI)=2.472(1.488～4.051)]。血清VitD ROC判断T细胞免疫功能低下的AUC(95%CI)为0.828(0.764～0.922),灵敏度和特异度分别为92.4%和63.8%。结论 血清VitD水平降低与TNBC患者T细胞免疫功能低下发生有关,血清VitD有望作为早期判断TNBC患者T细胞免疫功能的指标。
Abstract:
Abstract:Objective To explore the relationship between serum vitamin D(VitD)level and T Cell immune function in patients with triple-negative breast cancer(TNBC).Methods 153 cases TNBC patients with T Cell immunodeficiency(CD+4/CD8+<1.4,observation group)and 153 cases TNBC patients with T Cell normal immune function(CD+4/CD8+≥1.4,control group)were selected.Self-designed questionnaire was used to collect clinical data and ELISA method was used to detect serum VitD level.The relationship betweenVitD level and T Cell immune function were analyzed by logistic regression model.The sensitivity and the specificity of VitD level in the diagnosisof immunodeficiency in TNBC patients were evaluated by receiver operating characteristic curve(ROC).Results The level of VitD(ng/ml)in observation group was significantly lower than that in the control group(24.38±9.72 vs 31.12±14.42,t=2.52,P=0.00).The rate of VitD deficiencyin the observation group was higher than that in control group(62.7% vs 39.2%,χ2=16.02,P=0.00).Logistic regression showed that VitD deficiency was risk factor for immunodeficiency in TNBC patients[OR(95%CI)=2.472(1.488～4.051)].The areaunder the curve(AUC)of serum VitD ROC(95%CI)was 0.828(0.764～0.922),sensitivity and specificity were 92.4% and 63.8%.Conclusion The decrease of serum VitD level is associated with immunodeficiency in patients with TNBC,and serum VitD will be expected to be a biologicalmarker for early diagnosis of immunodeficiency in TNBC patients.

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备注/Memo

备注/Memo:
基金项目:河北省卫计委医学重点项目基金资助(20150973)。 作者简介:周 颖(1981-),女,大学本科,主管护师,主要研究方向:肿瘤学,E-mail:18333883633@163.com。
更新日期/Last Update: 2018-08-16