[1]权青云,赵 敏,张贵云,等.卒中后认知功能障碍患者血清低密度脂蛋白胆固醇测定的临床意义[J].现代检验医学杂志,2018,33(04):122-124.[doi:10.3969/j.issn.1671-7414.2018.04.033]
　QUAN Qing-yun,ZHAO Min,ZHANG Gui-yun,et al.Clinical Significance of Serum Low Density Lipoprotein Cholesterol of Patients with Post-Stroke Cognitive Impairment[J].Journal of Modern Laboratory Medicine,2018,33(04):122-124.[doi:10.3969/j.issn.1671-7414.2018.04.033]
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卒中后认知功能障碍患者血清低密度脂蛋白胆固醇测定的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年04期
页码:
122-124
栏目:
论著
出版日期:
2018-08-30

文章信息/Info

Title:
Clinical Significance of Serum Low Density Lipoprotein Cholesterol of Patients with Post-Stroke Cognitive Impairment
文章编号:
1671-7414(2018)04-122-03
作者:
权青云; 赵 敏; 张贵云; 张克举; 刘正军; 孙 鹃; 孙 权; 张 愉
武警陕西省总队医院干部病房,西安 710054
Author(s):
QUAN Qing-yun; ZHAO Min; ZHANG Gui-yun; ZHANG Ke-ju; LIU Zheng-jun; SUN Juan; SUN Quan; ZHANG Yu
Cardre Ward,Shaanxi Provincial Armed Police Corps Hospital,Xi'an 710054,China
关键词:
脑血管疾病;  认知功能障碍;  低密度脂蛋白胆固醇
分类号:
R743.3; R446.112
DOI:
10.3969/j.issn.1671-7414.2018.04.033
文献标志码:
A
摘要:
目的 探讨测定血清低密度脂蛋白胆固醇(serum low density lipoprotein cholesterol,LDL-C)与卒中后认知功能障碍(post-stroke cognitive impairment,PSCI)及其严重程度的相关性。方法 采用病例对照研究,选择2013年1月～2016年12月期间武警陕西省总队医院门诊及住院的PSCI患者68例作为研究对象,依据简易智力量表检测以及蒙特利尔认知评分检测结果,分为2组,其中轻度组(45例)和中重度组(23例),并选择同期在该院体检中心体检,体检结果各项指标均正常者70例为对照组。比较两组血清LDL-C水平及不同程度PSCI患者血清LDL-C水平。结果PSCI病例组血清LDL-C水平为3.42±0.26 mmol/L,正常对照组为2.16±0.31 mmol/L,组间比较差异有统计学意义(t=-2.532,P=0.008); 中重度PSCI组的血清LDL-C水平为3.61±1.39 mmol/L,轻度组为3.12±0.38 mmol/L,组间比较差异有统计学意义(t=-2.240,P=0.014)。结论 血清LDL-C水平是PSCI的重要危险因素,其水平可反映PSCI患者病情的严重程度。
Abstract:
Abstract:Objective To investigate the correlation between the serum low density lipoprotein cholesterol(LDL-C)and the post-stroke cognitive impairment(PSCI)and its severity.Methods Case-control studies were used.68 patients with PSCI were admitted in the Cardre Wards of the Shaanxi Provincial Armed Police Corps Hospital,ranging from January2013 to December 2016.According to the testing result of simple Intelligence Scale and Montreal Cognitive Score,the patients were divided into the mild cognitive impairment and the moderate and severe cognitive impairment.70 healthy controls at the same time were as the control group.Compared the serum LDL-C level between the two groups and compared the serum LDL-C level with different severity of PSCI.Results The levels of serum LDL-C of thepatients with PSCI was 3.42±0.26 mmol/L,and the control group was 2.16±0.31 mmol/L.It had statistical difference between the two groups(t=-2.532,P=0.008).The serum LDL-C of patients with the moderate and severe cognitiveimpairment group was 3.61±1.39 mmol/L,and the mild group was 3.12±0.38 mmol/L.It had statistical difference between the two groups(t=-2.240,P=0.014).Conclusion The levels of serum LDL-C is the important risk factor of the PSCI,and the levels of serum LDL-C can be responsed the severity of the patients with PSCI.

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备注/Memo

备注/Memo:
基金项目:武警陕西总队医院科研立项,项目编号:YNKYLX-2017005。 作者简介:权青云(1973-),女,在读博士,副主任医师,专业:神经病学和老年病学,E-mail:13669261090@163.com。 通讯作者:张 愉(1977-),女,学士,主治医师,专业:老年病学,E-mail:1583094500@qq.com。
更新日期/Last Update: 2018-08-16