[1]戴晓灵a,应红灵b.非甲状腺疾病患者血清T3FT3,T4FT4和sTSH水平同时下降的结果探讨[J].现代检验医学杂志,2018,33(04):144-145,148.[doi:10.3969/j.issn.1671-7414.2018.04.040]
　DAI Xiao-linga,YING Hong-lingb.Discussion on Simultaneous Decrease of the Level of Serum T3(F3),T4(FT4)and sTSH in Non-Thyroid Patients[J].Journal of Modern Laboratory Medicine,2018,33(04):144-145,148.[doi:10.3969/j.issn.1671-7414.2018.04.040]
点击复制

非甲状腺疾病患者血清T3FT3,T4FT4和sTSH水平同时下降的结果探讨()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年04期
页码:
144-145,148
栏目:
检验与临床
出版日期:
2018-08-30

文章信息/Info

Title:
Discussion on Simultaneous Decrease of the Level of Serum T3(F3),T4(FT4)and sTSH in Non-Thyroid Patients
文章编号:
1671-7414(2018)04-144-03
作者:
戴晓灵a; 应红灵b
重庆市万州区人民医院a.检验科; b.进修生 重庆404000
Author(s):
DAI Xiao-linga; YING Hong-lingb
a.Department of Clinical Laboratory; b.Advanced Student, People's Hospital of Wanzhou District in Chongqing,Chongqing 404000,China
关键词:
非甲状腺疾病;  甲状腺激素;  促甲状腺激素
分类号:
R581; R392.11
DOI:
10.3969/j.issn.1671-7414.2018.04.040
文献标志码:
A
摘要:
目的 探讨临床上部分非甲状腺疾病患者在无抗甲状腺药物治疗情况下,患者血清三碘甲状腺原氨酸(triiodothyronine,T3)、游离三碘甲状腺原氨酸(tree triiodothyronine,FT3)、甲状腺激素(thyroid hormone,T4)、游离甲状腺素(tree thyroxine,FT4)和超敏促甲状腺素(thyroid stimulating hormone,sTSH)水平同时下降的影响因素。方法 收集2016年1～12月在重庆市万州区人民医院住院期间的非甲状腺疾病患者172例作为观察组,并选择同期体检的健康者135例作为对照组,以化学发学法检测T3,FT3,T4,FT4及sTSH血清水平,两样本均数的比较采用t检验,比较两组的水平差异。结果 观察组与对照组比较,血清T3:0.68 ±0.25 nmol/L vs 1.63 ±0.32 nmol/L,FT3:2.77±0.45 pmol/L vs 4.71±0.77 pmol/L,T4:43.54±10.9 nmol/L vs 107.82±21.91 nmol/L,FT4:9.23±1.81 pmol/L vs 17.24±2.27 pmol/L和sTSH:0.150±0.144 mIU/L vs 2.253±1.25 mIU/L,其值均低于健康对照组,差异均有统计学意义(t=9.433 8～16.721 8,均P<0.01)。结论 非甲状腺疾病患者,血清T3(FT3),T4(FT4)及sTSH水平同时降低,是患者危重的一种机体代谢调节与自我保护,对临床甲状腺疾病的鉴别诊断及预后判断有重要意义。
Abstract:
Abstract:Objective To investigate the serum triiodothyronine(T3)and free triiodoronthyine(FT3)in some clinical patients with non-thyroid diseases without anti-thyroid medication,thyroid hormone(T4)and free thyroxine(FT4)and allergic to promote thyroxine(thyroid stimulating hormone,sTSH)level and the influence factors of decline.Methods Collected 172 patients with thyroid diseases in Wanzhou District People's Hospital of Chongqing from January 2016 to December 2016 as observation group,and selected 135 cases of healthy subjects as control group in the same period.Theirserum levels of T3,FT3,T4,FT4 and sTSH were detected with chemiluminescent method.The t test was used for comparison of two sample mean,comparing theirdifferences.Results Comparison between the observation group and the control group,serum T3:0.68± 0.25nmol/L vs 1.63±0.32 nmol/L,FT3:2.77±0.45 pmol/L vs 4.71±0.77 pmol/L,T4:43.54±10.9 nmol/L vs 107.82±21.91 nmol/L,FT4:9.23±1.81 pmol/L vs17.24±2.27 pmol/L,and sTSH:0.150±0.144 mIU/L vs 2.253±1.25 mIU/L,both of which were lower than the healthy control group,with statistically significant differences(t=9.433 8～16.721 8,all P<0.01).Conclusion The thyroid disease patients,serum T3(FT3),T4(FT4)and thelevel of sTSH reduced at the same time,is a kind of critically ill patients with the body's metabolic regulation and self protection,for the differential diagnosis and prognosis of thyroid disease clinical judgement is important.

参考文献/References:

[1] Murakami M.Nonthyroidal illness(NTI)[J].Nihon Rinsho:Japanese Journal of Clinical Medicine,2012,70(11),2005-2010.
[2] 李 欣,李景辉.非甲状腺疾病综合征再认识[J].海南医学,2012,23(2):128-130. Li X,Li JH.Recognition of non-thyroid syndrome[J].Hainan Medicine,2012,23(2):128-130.
[3] 刘 涛,彭 亮,侯彦强.非甲状腺疾病综合征的研究进展[J].中华临床医师杂志(电子版),2013,7(8):3546-3548. Liu T,Peng L,Hou YQ.Advances in studies on the comprehensive symptoms of non-thyroid diseases[J].Chinese Journal of Clinicians(Electronic Edition),2013,7(8):3546-3548.
[4] Wajner SM,Goemann I,Bueno AL,et al.IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while promoting thyroid hormone inactivation in human cells[J].J Clin Invest,2011,121(5):1834-1845.
[5] Mebis L,Debaveye Y,Ellger B,et al.Changes in the central component ofthe hypothalamus-pituitary-thyroid axis in a rabbit model of prolonged critical illness[J].Critical care,2009,13:R147.
[6] Galli E,Pingitore A,Iervasi G.The role of thyroid hormone in the pathophysiology of heart failure:clinical evidence[J].Heart Fail Rev,2010,15:155-169.
[7] Mebis L,van den Berghe G.The hypothalamuse-pituitary-thyroid axis incritical illness[J].Neth J Med,2009,67(10):332-340.
[8] 王 琴,赵小爱.130例中年非甲状腺疾病患者血清FT3,FT4和测定结果分析[J].甘肃医药,2016,35(5):330-332. Wang Q,Zhao XA.Analysis of serum FT3,FT4 and TSH in 130 cases elderly patients[J].Gansu Medicine Journal,2016,35(5):330-332.
[9] 马瑞婷,黄 慧,严悦溶,等.正常成人甲状腺激素水平影响因素探讨[J].四川大学学报(医学版),2015,46(4):611-614. Ma RT,Huang H,Yan YR,et al.Influence factors on serum thyroid hormone level in healthy people[J].Journal of Sichuan University(Medical Edition),2015,46(4):611-614.
[10] 缪 婕,赵咏桔,王 曙,等.Graves病患者甲状腺激素水平正常后sTSH长期受抑制机制的探讨[J].中华内分泌代谢杂志,2008,24(2):170-173. Miao J,Zhao YJ,Wang S,et al.Mechanism of presistent thyrotropin suppression in euthyroid patients with Graves' disease after treatment[J].ChineseJournal of Endocrine Metabolism,2008,24(2):170-173.
[11] 戴晓灵,向明民.Graves病131I治疗后对sTSH检测受抑制的因素探讨[J].现代检验医学杂志,2012,27(3):76-77. Dai XL,Xiang MM.Discussion on factors that inhibit sTSH detection aftertreatment with Graves' disease131I[J].Journal of Modern Laboratory Medicine,2012,27(3):76-77.
[12] Pappa TA,Vagenakis AG,Alevizaki M.The nonthyroidal illness syndrome in the non-critically ill patient[J].Eur J Clin Invest,2011,41(2):212-220.
[13] Iglesias P,Mun(¨overo)z A,Prado F,et al.Alterations in thyroid function tests in aged hospitalized patients:prevalence,aetiology and clinicaloutcome[J].Clin Endocrinol(Oxf),2009,70(6):961-967.

相似文献/References:

[1]孙继红,张 艳,剌 梅,等.中老年人群甲状腺激素与血清NT-proBNP的相关性研究分析[J].现代检验医学杂志,2015,30(04):147.[doi:10.3969/j.issn.1671-7414.2015.04.045]
　SUN Ji-hong,ZHANG Yan,LA Mei,et al.Correlation Analysis of Serum Thyroid Hormone NT-proBNP in OlderAdults[J].Journal of Modern Laboratory Medicine,2015,30(04):147.[doi:10.3969/j.issn.1671-7414.2015.04.045]
[2]段侠霞a,张 燕b,贺瑞峰a,等.儿童青少年精神分裂症与血清甲状腺激素水平的相关性分析[J].现代检验医学杂志,2018,33(06):80.[doi:10.3969/j.issn.1671-7414.2018.06.021]
　DUAN Xia-xiaa,ZHANG Yanb,HE Rui-fenga,et al.Correlation Analysis on Children and Adolescents with Schizophrenia and Serum Thyroid Hormones[J].Journal of Modern Laboratory Medicine,2018,33(04):80.[doi:10.3969/j.issn.1671-7414.2018.06.021]
[3]谭志敏,张 燕,滕雅娟,等.糖尿病肾病患者血清甲状腺激素水平变化及其与亚临床甲状腺功能减退的相关性[J].现代检验医学杂志,2018,33(06):95.[doi:10.3969/j.issn.1671-7414.2018.06.025]
　TAN Zhi-min,ZHANG Yan,TENG Ya-juan,et al.Correlation between Serum Thyroid Hormone Levels in Patients with Diabetic Kidney Disease and Subclinical Hypothyroidism[J].Journal of Modern Laboratory Medicine,2018,33(04):95.[doi:10.3969/j.issn.1671-7414.2018.06.025]
[4]马 润,沈秀芬,陈孝红,等.昆明地区不同妊娠期妇女甲状腺功能指标参考区间的调查及变化分析[J].现代检验医学杂志,2020,35(01):97.[doi:10.3969/j.issn.1671-7414.2020.01.026]
　MA Run,SHEN Xiu-fen,CHEN Xiao-hong,et al.nvestigation and Change Analysis of Reference Intervals ofThyroid Function Indicators for Women at Different Stages of Pregnancy in Kunming[J].Journal of Modern Laboratory Medicine,2020,35(04):97.[doi:10.3969/j.issn.1671-7414.2020.01.026]

备注/Memo

备注/Memo:
作者简介:戴晓灵(1962-),男,大专,副主任检验师,现任重庆市核医学专委会委员,从事核医学和临床检验,E-mail:448256359@qq.com。
更新日期/Last Update: 2018-08-16