[1]陈立勇,张 静,陈尊义,等.慢性荨麻疹与幽门螺杆菌感染相关性探究[J].现代检验医学杂志,2018,33(04):146-148.[doi:10.3969/j.issn.1671-7414.2018.04.041]
　CHEN Li-yong,ZHANG Jing,CHEN Zun-yi,et al.Investigation of the Correlation between Chronic Urticaria and Helicobacter Pylori Infection[J].Journal of Modern Laboratory Medicine,2018,33(04):146-148.[doi:10.3969/j.issn.1671-7414.2018.04.041]
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慢性荨麻疹与幽门螺杆菌感染相关性探究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年04期
页码:
146-148
栏目:
检验与临床
出版日期:
2018-08-30

文章信息/Info

Title:
Investigation of the Correlation between Chronic Urticaria and Helicobacter Pylori Infection
文章编号:
1671-7414(2018)04-146-03
作者:
陈立勇1; 张 静2; 陈尊义1; 喻惠元1; 付天琪1; 刘 玮1; 章 旭1; 曹永艳1
1.武汉市第一医院皮肤科,武汉 430030; 2.华中科技大学同济医学院附属同济医院创伤外科,武汉 430030
Author(s):
CHEN Li-yong1; ZHANG Jing2; CHEN Zun-yi1; YU Hui-yuan1; FU Tian-qi1; LIU Wei1;  ZHANG Xu1; CAO Yong-yan1
1.Department of Dermatology,Wuhan NO.1 Hospital, Wuhan 430030,China; 2.Department of Trauma Surgery,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
关键词:
慢性荨麻疹;  幽门螺杆菌;  13C尿素呼气试验
分类号:
R758.24; R378.2
DOI:
10.3969/j.issn.1671-7414.2018.04.041
文献标志码:
A
摘要:
目的 探究慢性荨麻疹(chronic urticaria,CU)与幽门螺杆菌(Hp)感染之间深层次的相关性关系,为临床治疗慢性荨麻疹患者提供更有效的诊疗策略。方法 收集2016年12月～2017年12月在武汉市第一医院就诊的217例慢性荨麻疹患者和同期就诊的131例健康志愿者,分别作为实验组和对照组。采用13C尿素呼气试验检测其Hp感染情况,所有结果进行统计学分析。结果 慢性荨麻疹组Hp阳性率为31.3%,健康对照组为21.4%,慢性荨麻疹患者阳性率明显高于健康对照组,差异有统计学意义(χ2=4.058,P<0.05)。更进一步地,在慢性荨麻疹患者中,Hp阳性率与年龄具有相关性,而与性别并无相关性; 41～55岁年龄段慢性荨麻疹患者组Hp阳性率明显高于其他年龄组,差异有统计学意义(χ2=8.126,P<0.05)。结论 慢性荨麻疹患者与幽门螺杆菌感染具有一定的相关性,幽门螺杆菌可能参与了慢性荨麻疹的发生与发展。尤其是对于41～55岁之间的慢性荨麻疹患者,由于其相对更高的Hp感染率,十分有必要进行Hp检测。
Abstract:
Abstract:Objective To investigate the relationship between chronic urticaria(CU)and Helicobacter pylori(Hp)infection so as to provide efficient treatment for CU patients.Methods 217 cases of CU patients and 131 healthy volunteers were recruited during December 2016 to December 2017 in Wuhan NO.1 Hospital.They were separately defined as experimental and control groups.13C-urea breath test(13C-UBT)was used to determine Hp infection.The results were analyzed statistically.Results The Hp-positive rate(31.3%)in CU patients was higher than that in healthy controls(21.4%)(χ2=4.058,P< 0.05)respectively.In CU patients,the Hp- positive rate was correlated with age but not with gender,and the Hp -positive rate was significantly higher(41～55 years-old group)than any other age group(χ2=8.126,P<0.05)respectively.Conclusion Hp infection was closely associated with CU,which suggested Hp might participate in the pathogenesis of CU.For the middle-aged CUpatients(41～55 years-old).It is necessary to be performed with Hp test because of its high infection rate.

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备注/Memo

备注/Memo:
作者简介:陈立勇(1990-),男,硕士,初级检验技师,主要从事免疫病理及分子免疫研究,E-mail:maitianc66@163.com。 通讯作者:曹永艳(1976-),女,主管技师。
更新日期/Last Update: 2018-08-16