[1]刘 然.体质指数与血清C反应蛋白和糖化血红蛋白在妊娠期糖尿病诊断中的意义[J].现代检验医学杂志,2018,33(05):49-52.[doi:10.3969/j.issn.1671-7414.2018.05.014]
　LIU Ran.Diagnostic Significance of BMI,Serum CRP and HbA1c in Gestational Diabetes Mellitus[J].Journal of Modern Laboratory Medicine,2018,33(05):49-52.[doi:10.3969/j.issn.1671-7414.2018.05.014]
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体质指数与血清C反应蛋白和糖化血红蛋白在妊娠期糖尿病诊断中的意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年05期
页码:
49-52
栏目:
论著
出版日期:
2018-11-18

文章信息/Info

Title:
Diagnostic Significance of BMI,Serum CRP and HbA1c in Gestational Diabetes Mellitus
文章编号:
1671-7414(2018)05-049-04
作者:
刘 然
北京妇产科医院检验科,北京 100026
Author(s):
LIU Ran
Department of Clinical Laboratory, Beijing Obstetrics and Gynecology Hospital,Beijing 100026,China
关键词:
妊娠期糖尿病;  体重指数;  C-反应蛋白;  糖化血红蛋白
分类号:
R714.256; R446.112
DOI:
10.3969/j.issn.1671-7414.2018.05.014
文献标志码:
A
摘要:
目的 探究体质指数(body mass index,BMI)、血清C反应蛋白(C reactive protein,CRP)和糖化血红蛋白(hemoglobin A1c,HbA1c)在妊娠期糖尿病(gestational diabetes mellitus,GDM)诊断中的临床意义。方法 自2016年5月～2017年5月收集90例确诊GDM患者作为实验组,同期收集90例健康孕妇作为对照组,分别评估两组受检者BMI,检测两组受检者CRP和HbA1c水平,使用χ2检验分析两组受检者BMI差异,t检验分析两组受检者CRP和HbA1c水平差异,Logistic回归分析BMI,CRP,HbA1c与GDM患病风险的相关性。结果 GDM组孕前超重(47.78% vs 27.78%,χ2=7.658,P<0.05)和肥胖(58.89% vs 31.11%,χ2=14.029,P<0.05)孕妇比例均高于对照组,差异均有统计学意义; GDM组孕妇CRP(10.65±0.83 mg/L vs 2.33±0.62 mg/L,t=76.188,P<0.05)和HbA1c[(10.08±0.76)×109/L vs(4.47±0.53)×109/L,t=57.439,P<0.05)]水平均显著高于对照组,差异均有统计学意义; Logistic回归显示CRP,BMI和HbA1c均与GDM患病风险呈正相关(P<0.05)。结论 GDM患者孕前BMI,CRP和HbA1c均显著高于健康孕妇,且与GDM患病风险呈正相关,可作为GDM早期临床诊断的指标。
Abstract:
Objective To investigate the clinical value ofbody mass index(BMI),serum C reactive protein(CRP)and glycated hemoglobin(HbA1c)in the diagnosis of gestational diabetes mellitus(GDM)patients with gestational diabetes mellitus(GDM).Methods 90 patients with GDM diagnosed in Beijing Obstetrics and Gynecology Hospital from May 2016 toMay 2017 were selected as observation group and 90 healthy pregnant women who underwent pregnancy examination in the same period as control group.The levels of BMI,CRP and HbA1c were measured in two groups.The difference of BMI,CRP andHbA1c between two groups were analyzed by χ2 test or t test.Logistic regression was used to analyze the association of BMI,CRP,HbA1c and the riskof GDM.Results Before pregnancy,the proportion of overweight(47.78% vs 27.78%,χ2=7.658,P<0.05)and obesity(58.89% vs 31.11%,χ2=14.029,P<0.05)in GDM group was higher than that in controlgroup.The level of CRP(10.65±0.83 mg/L vs 2.33±0.62 mg/L,t=76.188,P<0.05)and HbA1c [(10.08±0.76)×109/L vs(4.47±0.53)×109/L,t=57.439,P <0.05)] were also significantly higher than that in control group.Logistic regression showed that CRP,BMI and HbA1c were all related to the risk of GDM(P<0.05).Conclusion The BMI,CRP and HbA1cin GDM patients were significantly higher than that in control group.These indexes were positively correlated with the incidence of GDM and could be used forearly clinical diagnosis of GDM.

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备注/Memo

备注/Memo:
作者简介:刘 然(1988-),女,本科,初级检验师,E-mail:527806094@qq.com。
更新日期/Last Update: 2018-09-30