[1]杨宏秀,刘 丽,张会芬,等.血清抗中性粒细胞胞浆抗体及相关炎性因子检测对糖尿病肾病的诊断价值[J].现代检验医学杂志,2018,33(05):95-97+101.[doi:10.3969/j.issn.1671-7414.2018.05.025]
　YANG Hong-xiu,LIU Li,ZHANG Hui-fen,et al.Diagnostic Value of Detection Anti-Cardiolipin Antibodies and Related Inflammatory Factors in Diabetic Nephropathy[J].Journal of Modern Laboratory Medicine,2018,33(05):95-97+101.[doi:10.3969/j.issn.1671-7414.2018.05.025]
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血清抗中性粒细胞胞浆抗体及相关炎性因子检测对糖尿病肾病的诊断价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年05期
页码:
95-97+101
栏目:
论著
出版日期:
2018-11-18

文章信息/Info

Title:
Diagnostic Value of Detection Anti-Cardiolipin Antibodies and Related Inflammatory Factors in Diabetic Nephropathy
文章编号:
1671-7414(2018)05-095-04
作者:
杨宏秀; 刘 丽; 张会芬; 袁宝军; 夏彦东
唐山开滦总医院检验科,河北唐山 063000
Author(s):
YANG Hong-xiu; LIU Li; ZHANG Hui-fen; YUAN Bao-jun; XIA Yan-dong
Department of Clinical Laboratory,Kailuan General Hospital,Hebei Tangshan 063000,China
关键词:
抗中性粒细胞胞浆抗体;  中性粒细胞明胶酶相关脂质运载蛋白;  超敏C反应蛋白;  糖尿病肾病
分类号:
R587.2; R392.11
DOI:
10.3969/j.issn.1671-7414.2018.05.025
文献标志码:
A
摘要:
目的 探讨血清抗中性粒细胞胞浆抗体(ACA)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)及超敏C-反应蛋白(hs-CRP)的检测对糖尿病肾病(DN)的诊断价值。方法 选择2型糖尿病患者176例,依据尿微量清蛋白排泄率(UACR)分为单纯糖尿病组(DM组)、早期糖尿病肾病组(EDN组)和临床糖尿病肾病组(CN组),同时选取健康体检者60例作为对照组(NC组)。采用间接酶联免疫法检测ACA,免疫比浊法分析血清NGAL和hs-CRP水平。结果 与NC组比较,DM组NGAL,hs-CRP及ACA-IgM水平升高,差异有统计学意义(P<0.05或P<0.01); EDN组NGAL,hs-CRP,ACA-IgG和ACA-IgA水平升高,差异均有统计学意义(P<0.05或P<0.01); CN组NGAL,hs-CRP,ACA-IgG和ACA-IgA水平升高,差异有统计学意义(P<0.05或P<0.01); 与DM组比较,EDN组NGAL和hs-CRP水平升高,差异有统计学意义(P<0.05),CN组NGAL,hs-CRP和ACA-IgA水平升高,差异有统计学意义(P<0.05或P<0.01); 与EDN组比较,CN组NGAL和hs-CRP水平升高,差异有统计学意义(P<0.01)。NGAL,hs-CRP及ACA-IgA分别与ACR呈正相关(r=0.510,0.366,0.206,均P<0.01)。结论 血清NGAL,hs-CRP和ACA-IgM可提示早期肾损害,NGAL,hs-CRP及ACA可作为DN病情进展过程中的监测指标。
Abstract:
Objective To investigate the diagnostic value of serum neutrophil gelatinase-associated lipocalin(NGAL),hypersensitive C-reactive protien(hs-CRP)and anti-cardiolipin antibodies(ACA)in diabetic nephropathy(DN).Methods 176 patients with type 2 diabetes mellitus(T2DM)were divided into three groups according to anurinary albumin to creatinine ratio(ACR):diabetic mellitus group(DM group),early diabetic nephropathy group(EDN group)and clinic diabetic nephropathy group(CN group).60 healthy subjects in the same period determined by physical examination were enrolledas the control group(NC group).Analyzed ACA levels among 4 groups by indirectimmunofluorescence,while NGAL and hs-CRP were measured by immunoturbidimetry.Results Compared with NC group,NGAL,hs-CRP and anti-cardiolipin antibodies immune globulin M(ACA-IgM)levels in DM group were increased,and levels of NGAL,hs-CRP,anti-cardiolipin antibodies immune globulin G(ACA-IgG)and anti-cardiolipin antibodies immune globulin A(ACA-IgA)in EDN group and CN group were higher than those in NC group,the differences had statistical significance(P<0.05 or P<0.01).Compared with DM group,levels of NGAL and hs-CRP in EDN group were increased,while levels of NGAL,hs-CRP and ACA-IgA in CN group were also increased,the differences had statistical significance(P<0.05 or P<0.01),and CN group compared with EDN group, NGAL and hs-CRP levels were increased,the differences had statistical significance(P<0.01).ACR was negatively correlated with NGAL,hs-CRP and ACA-IgA(r=0.510,0.366,0.206,P<0.01).Conclusion Levels of NGAL,hs-CRP and ACA-IgM can remind early renal damage,while levels of NGAL,hs-CRP and ACA can monitor the progress of DN.

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备注/Memo

备注/Memo:
作者简介:杨宏秀(1985-),女,大学本科,学士学位,主管检验师,主要从事临床检验医学的研究。
通讯作者:袁宝军,E-mail:ybj25999@163.com.
更新日期/Last Update: 2018-09-30