[1]孙建方,蔡新红,蒋冯霞,等.江苏省张家港地区妊娠妇女红细胞叶酸水平调查[J].现代检验医学杂志,2018,33(05):117-120.[doi:10.3969/j.issn.1671-7414.2018.05.032]
　SUN Jian-fang,CAI Xin-hong,JIANG Feng-xia,et al.Investigation of Erythrocyte Folic Acid Level in Pregnant Women in Zhangjiagang of Jiangsu[J].Journal of Modern Laboratory Medicine,2018,33(05):117-120.[doi:10.3969/j.issn.1671-7414.2018.05.032]
点击复制

江苏省张家港地区妊娠妇女红细胞叶酸水平调查()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年05期
页码:
117-120
栏目:
论著
出版日期:
2018-11-18

文章信息/Info

Title:
Investigation of Erythrocyte Folic Acid Level in Pregnant Women in Zhangjiagang of Jiangsu
文章编号:
1671-7414(2018)05-117-04
作者:
孙建方; 蔡新红; 蒋冯霞; 陈 静
张家港市妇幼保健所,江苏张家港 215600
Author(s):
SUN Jian-fang; CAI Xin-hong; JIANG Feng-xia; CHEN Jing
Zhangjiagang Maternal and Child Health Care Institute,Jiangsu Zhangjiagang 215600,China
关键词:
叶酸;  红细胞叶酸;  化学发光法;  孕妇
分类号:
R715.3
DOI:
10.3969/j.issn.1671-7414.2018.05.032
文献标志码:
A
摘要:
目的 分析张家港地区妇女妊娠早、中、晚各期红细胞叶酸水平,探讨红细胞叶酸水平在孕期的变化,全方位对孕妇孕期保健提供科学诊断依据。方法 对2014年8月8日～2015年6月23日在张家港市妇幼保健所建卡的665例孕妇,采用Beckman Coulter Access2化学发光免疫测定方法,定量测定妊娠早、中、晚各期红细胞叶酸水平。结果 妊娠早、中、晚期红细胞叶酸含量分别为672.27±212.38,862.41±276.17和 818.25±290.96 ng/ml,不同孕期间红细胞叶酸水平差异有统计学意义(t=-21.557,-14.696,5.260,均P<0.01)。从检测数据来看,张家港市孕妇总体红细胞叶酸水平在正常范围,孕早期相对孕中、晚期稍低; 孕早期20～30岁和大于30岁年龄段红细胞叶酸水平低于推荐值者占6.51%(43/661)。结论 张家港市孕妇红细胞叶酸水平处于相对可控范围,部分孕妇孕早期相对略低可能与主动补充叶酸的频率有关,不断提高补充叶酸依从性不容忽视。
Abstract:
Objective To analyze the levels of erythrocytefolic acid in early,middle and late pregnancy of women in Zhangjiagang Area,and explore the changes of erythrocyte folic acid in pregnancy,so as to provide scientific basis for pregnant women's health care.Methods From August 8,2014 to June 23,2015,665 pregnant women with cards established in Zhangjiagang Maternal and Child Health Center were measured by Beckman Coulter Access 2 chemiluminescent immunoassay.Results The mean levels of erythrocyte folic acid in early,middle and late pregnancy were672.27±212.38,862.41±276.17 and 818.25±290.96 ng/ml,respectively.Therewas a significant difference in the levels of erythrocyte folic acid in different pregnancy stages(t=-21.557,-14.696,5.260,all P<0.01).According to the test data,the erythrocyte folic acid level of pregnant women in Zhangjiagang city was in the normal range,which was slightly lower in the early pregnancy than in the middle and late pregnancy.Conclusion Erythrocyte folic acid level of pregnant women in Zhangjiagang City was in a relatively controllable range,and the relatively low level of some early pregnancy could be related to the frequency of active folic acid supplementation.Continuous improvement of folic acid supplementation compliance should not be ignored.

参考文献/References:

[1] Donnelly J.Folic Acid[J].Critical Reviews in Clinical Laboratory Sciences,2001,38(3):183-223.
[2] Snow CF.Laboratory diagnosis of vitamin B12 and folate deficiency:A guide for the primary care physician[J].Arch intern Med,1999,159(12):1289-1298.
[3] Fairbanks VF,Klee G,Virgil F.Biochemical aspects of hematology[M].3th Ed.Philadelphia:WB Saunders,1999:1642-1710.
[4] Daly LE,Kirke PN,Molloy A,et al.Folate levels and neural tube defects lmplications for prevention[J].JAMA,1995,274(21):1698-1702.
[5] 滕 越,胡京苗,董 珊,等.北京地区孕早期妇女红细胞叶酸水平及适宜叶酸补充时间剂量[J].卫生研究,2017,46(4):569-572,578.
Teng Y,Hu JM,Dong S,et al.Concentration of red blood cell folateand the analysis of folic acid supplement optimum time and dose in first trimester[J].Journal of Hygiene Research,2017,46(4):569-572,578.
[6] 速存梅,叶汉风,王 珏,等.育龄妇女血清叶酸及红细胞叶酸水平检测分析[J].中华妇幼临床医学杂志(电子版),2012,8(6):589-592.
Su CM,Ye HF,Wang J,et al.Analysis of serum folic acid and red blood cell folic acid comcentration among childbearing aged[J].Chin J Obstet Gynecol Pediatr(Electron Ed),2012,8(6):589-592.
[7] 廖亚平,李蕾娜,鲍明升,等.MTHFR,MTRR和M-TR基因多态性与唐氏综合征发生的相关性研究[J].激光生物学报,2010,19(3):358-362.
Liao YP,Li LN,Bao MS,et al.Relationship between the polymorphisms in genes of MTHFR,MTRR and MTR and the risk of delivering a child with Down's Syndrome[J].Acta Laser Biology Sinica,2010,19(3):358-362.
[8] 贺建勋,袁 慧.电化学发光法测定红细胞叶酸水平的性能评价[J].标记免疫分析与临床,2014,21(3):315-317.
He JX,Yuan H.Determination of red cell folate concentrations withelectrochemilumineseenee method[J].Labeled Immunossays & Clin Med,2014,21(3):315-317.
[9] 归巧娣,苍金荣,宫艳艳,等.西安地区育龄妇女MTHFRC677T基因型分布研究[J].现代检验医学杂志,2015,30(6):36-41,45.
Gui QD,Cang JR,Gong YY,et al.Geographical distribution of MTHFRC677T gene among the gestational age womenin Xi'an[J].Journal of Modern Laboratory Medicine,2015,30(6):36-41,45.
[10] 王 涛,高劲松,边旭明,等.红细胞叶酸水平及叶酸代谢相关基因多态性与不良妊娠结局的相关性研究[J].生殖医学杂志,2010,19(1):48-52.
Wang T,Gao JS,Bian XM,et al.Study on the relationship of erythrocyte folate status,polymorphic variation in folate-related genes and adverse pregnancy outcomes[J].Journal of Reproductive Medicine,2010,19(1):48-52.
[11] 孙 红,王留娣.124例孕妇妊娠期血清叶酸水平动态观察[J].上海预防医学,2002,14(2):60-61.
Sun H,Wang LD.Observation on serum folic acid trend of 124 pregnant women[J].Shanghai Journal of Preventive Medicine,2002,14(2):60-61.

相似文献/References:

[1]张瑞.脑梗死患者血清同型半胱氨酸、血浆叶酸和维生素B12水平的相关性研究[J].现代检验医学杂志,2015,30(05):118.[doi:10.3969/j.issn.1671-7414.2015.05.036]
　ZHANG Rui.Correlation Study on Homocysteine，Plasma Folate and Vitamin B12 Levels in Serum of Cerebral Infarction Patients[J].Journal of Modern Laboratory Medicine,2015,30(05):118.[doi:10.3969/j.issn.1671-7414.2015.05.036]
[2]王 艳,张 华,阮华玲,等.老年颈动脉粥样硬化叶酸、VitB12治疗患者血清HIF-1α,CD62p和hsCRP水平表达的变化[J].现代检验医学杂志,2018,33(06):99.[doi:10.3969/j.issn.1671-7414.2018.06.026]
　WANG Yan,ZHANG Hua,RUAN Hua-ling,et al.Changes of Serum HIF-1α,CD62p and hsCRP Expression in Elderly Patients Treated with Folic Acid and VitB12[J].Journal of Modern Laboratory Medicine,2018,33(05):99.[doi:10.3969/j.issn.1671-7414.2018.06.026]
[3]曹云,周晓,张晓艳,等.陕西省延安地区育龄女性MTHFR基因多态性和国内多地区相关报道比较分析2)[J].现代检验医学杂志,2019,34(01):62.[doi:10.3969/j.issn.1671-7414.2019.01.016]
　CAO Yun,ZHOU Xiao,ZHANG Xiao-yan,et al.Comparative Analysis of MTHFR Gene Polymorphisms in Women of Childbearing Age in Yan’an Area of Shaanxi Province and Related Reports in Many Regions in China[J].Journal of Modern Laboratory Medicine,2019,34(05):62.[doi:10.3969/j.issn.1671-7414.2019.01.016]
[4]段侠霞,陈英,沈德华,等.儿童及青少年精神分裂症患者血清同型半胱氨酸、叶酸水平与PANSS评分的关系研究[J].现代检验医学杂志,2019,34(01):104.[doi:10.3969/j.issn.1671-7414.2019.01.027]
　DUAN Xia-xia,CHEN Ying,SHEN De-hua,et al.Correlation Study between Serum Homocysteine，Folic Acid Levels and PANSS Score in Children and Adolescents Patients with Schizophrenia[J].Journal of Modern Laboratory Medicine,2019,34(05):104.[doi:10.3969/j.issn.1671-7414.2019.01.027]
[5]左　林,赵　佳,姜小建,等.血清同型半胱氨酸、叶酸、维生素 B12水平与老年脑白质疏松症的相关性[J].现代检验医学杂志,2019,34(06):90.[doi:10.3969 ／ j.issn.1671-7414.2019.06.022]
　ZUO Lin,ZHAO Jia,JIANG Xiao-jian,et al.Correlation Study between Serum Homocysteine , Folate, Vitamin B12 Levels and Leukoaraiosis in Elderly Patients[J].Journal of Modern Laboratory Medicine,2019,34(05):90.[doi:10.3969 ／ j.issn.1671-7414.2019.06.022]
[6]师文涛,白 蓉,黄剑林,等.陕西省延安地区汉族与国内其他地区育龄妇女 MTHFR 基因 C677T 位点基因型和等位基因分布研究[J].现代检验医学杂志,2020,35(06):78.[doi:doi:10.3969/j.issn.1671-7414.2020.06.019]
　SHI Wen-tao,BAI Rong,HUANG Jian-lin,et al.Comparative Study on MTHFR Gene C677T Locus Genotype and AlleleDistribution between Han Nationality and Women of ChildbearingAge in Yan’an Area of Shaanxi Province[J].Journal of Modern Laboratory Medicine,2020,35(05):78.[doi:doi:10.3969/j.issn.1671-7414.2020.06.019]
[7]毕开湘a,陶红莉,杨丽丽 b.孤独症谱系障碍儿童血清叶酸与脑源性神经营养因子水平检测的临床意义[J].现代检验医学杂志,2020,35(06):171.[doi:doi:10.3969/j.issn.1671-7414.2020.06.042]
　BI Kai-xiang a,TAO Hong-li,YANG Li-li b.Clinical Significance of the Detection of Folic Acid and Brain-derivedNeurotrophic Factor in Children with Autism Spectrum Disorder[J].Journal of Modern Laboratory Medicine,2020,35(05):171.[doi:doi:10.3969/j.issn.1671-7414.2020.06.042]

备注/Memo

备注/Memo:
作者简介:孙建方(1968-),男,本科,副主任技师,从事优生优育产前筛查工作,E-mail:168073620@qq.com。
更新日期/Last Update: 2018-09-30