[1]马 莹,姜小建,赵 佳.血清免疫球蛋白检测在慢性乙型肝炎和乙肝肝硬化中的临床意义[J].现代检验医学杂志,2018,33(05):123-125.[doi:10.3969/j.issn.1671-7414.2018.05.034]
　MA Ying,JIANG Xiao-jian,ZHAO Jia.Clinical Significance of Serum Immunoglobulin Detection in Chronic Hepatitis B and Hepatitis B Cirrhosis[J].Journal of Modern Laboratory Medicine,2018,33(05):123-125.[doi:10.3969/j.issn.1671-7414.2018.05.034]
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血清免疫球蛋白检测在慢性乙型肝炎和乙肝肝硬化中的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年05期
页码:
123-125
栏目:
论著
出版日期:
2018-11-18

文章信息/Info

Title:
Clinical Significance of Serum Immunoglobulin Detection in Chronic Hepatitis B and Hepatitis B Cirrhosis
文章编号:
1671-7414(2018)05-123-03
作者:
马 莹; 姜小建; 赵 佳
西安市中心医院检验科,西安 710003
Author(s):
MA Ying; JIANG Xiao-jian; ZHAO Jia
Department of Clinical Laboratory,Xi'an Central Hospital,Xi'an 710003,China
关键词:
慢性乙型肝炎;  乙型肝炎肝硬化;  免疫球蛋白
分类号:
R512.62; R446.61
DOI:
10.3969/j.issn.1671-7414.2018.05.034
文献标志码:
A
摘要:
目的 探讨血清免疫球蛋白IgA,IgM和IgG检测在慢性乙型肝炎(chronic hepatitis B,CHB)和乙肝肝硬化(chepatitis B cirrhosis,HBC)中的临床意义。方法 选取2017年1月～2018年3月在西安市中心医院治疗的CHB患者80例和HBC患者78例(代偿期55例和失代偿期23例)作为研究对象,另选取同期健康体检者80例作为对照组,应用免疫散射比浊法检测各组血清IgA,IgM和IgG水平。结果 CHB组血清IgA和IgG水平显著高于对照组,HBC组血清IgA,IgM和IgG水平显著高于对照组,HBC组血清IgA和IgG水平显著高于CHB组,差异具有统计学意义(t=2.009～6.804,均P<0.05)。肝硬化失代偿期组血清IgA水平显著高于代偿期组,差异具有统计学意义(t=2.333,P<0.05)。结论 血清免疫球蛋白检测对于CHB和HBC患者的病情判断、临床治疗及预后评估具有重要的临床意义。
Abstract:
Objective To investigate the clinical significance of serum immunoglobulin IgA, IgM and IgG detection in chronic hepatitis B(CHB)and hepatitis B cirrhosis(HBC).Methods 80 cases of CHB and 78 cases of HBC(55 cases in compensatory period and 23 cases in decompensatory period)in Xi'an Central Hospital from January 2017 to March 2018 were selected as the research subjects.In addition,80 healthy persons in the same period were selected as control group.The levels of serum IgA,IgM and IgG were detected by immunoturbidimetry.Results The levels of serum IgA and IgG in CHB group were significantly higher than those in control group,the levels of serum IgA,IgM andIgG in HBC group were significantly higher than those in control group,and the levels of serum IgA and IgG in HBC group were significantly higher than those in CHB group,the differences were statistically significant(t=2.009～6.804, all P<0.05).The level of serum IgA in decompensated cirrhosis group was significantly higher than that in compensated cirrhosis group,the difference was statistically significant(t=2.333,P<0.05).Conclusion Detectionof serum immunoglobulin has important clinical significance for the diagnosis,clinical treatment and prognosis evaluation of the patients with CHB andHBC.

参考文献/References:

[1] 王 姣,邓 洪,谢冬英,等.HBV特异性CTLs表面CD244和PD-1共表达与慢性乙型肝炎严重程度的相关性[J].中华病理生理杂志,2012,28(12):2254-2260.
Wang J,Deng H,Xie DY, et al.Correlation between clinical stagesof HBV chronic infection and co-ex-pression of CD244 and PD-1 in HBV-specific CTLs[J].Chinese Journal of Pathophysiology,2012,28(12):2254-2260.
[2] 陈金图.免疫球蛋白联合常规方法在肝病患者血清检测中的应用研究[J].中外医学研究,2015,13(35):78-79.
Chen JT.Application of immunoglobulin combined with conventional method in serum detection of patients with liver disease[J].Chinese and ForeignMedical Research,2015,13(35):78-79.
[3] 中华医学会肝病学分会,中华医学会感染病学分会.慢性乙型肝炎防治指南(2015年版)[J/CD].中华实验和临床感染病杂志(电子版),2015,9(5):570-589.
Chinese Society of Hepatology and Chinese Society of Infectious Diseases,Chinese Medical Association.The guideline of prevention and treatment forchronic hepatitis B:a 2015 update[J/CD].Chinese Journal of Experimental andClinical Infectious Disease(Electronic Edition),2015,9(5):570-589.
[4] 周臣敏.免疫球蛋白检测在乙型肝炎患者病情及预后判断的临床意义[J].国际检验医学杂志,2013,34(3):376-377.
Zhou CM.Clinical significance of immunoglobulin detection in the diagnosis and prognosis of hepatitis B patients[J].International Journal of Laboratory Medicine,2013,34(3):376-377.
[5] 王 烈,胡义忠,徐秀亮,等.血清sP-selectin,sICAM-1和免疫球蛋白检测对乙肝肝硬化预后评估的意义[J].中国免疫学杂志,2017,33(11):1699-1705.
Wang L,Hu YZ,Xu XL,et al.Prognostic significance of serum sP-selectin,sICAM-1 and immunoglobulin in patients with hepatitis B cirrhosis[J].Chinese Journal of Immunology,2017,33(11):1699-1705.
[6] 何涛君,吴正林,钟小强,等.乙肝患者HBV载量与IgA,IgG,IgM及C3,C4相关性研究[J].现代检验医学杂志,2015,30(4):67-70.
He TJ,Wu ZL,Zhong XQ,et al.Study on the relationship between patients with hepatitis B viral loads and immunoglobulin A,G,M and complement C3,C4[J].Journal of Modern Laboratory Medicine,2015,30(4):67-70.
[7] 梁志军,李瑞娟,王素娜,等.乙肝肝硬化对外周血T细胞亚群、免疫球蛋白及补体水平的影响[J].陕西医学杂志,2017,46(12):1655-1656.
Liang ZJ,Li RJ,Wang SN,et al.Influence of hepatitis B cirrhosison peripheral blood T lymphocyte subsets,immunoglobulin and complement levels[J].Shaanxi Medical Journal,2017,46(12):1655-1656.
[8] Lin S,Sun QQ,Mao WL,et al.Serum immunoglobulin A(IgA)level is a potential biomarker indicating cirrhosis during chronic hepatitis B infection[J].Gastroenterol Res Pract,2016,2016(3):1-6.
[9] 杨 清,刘志勇,刘杉珊,等.慢性乙型肝炎和肝硬化患者血清IgG检测及与肝纤维化的关系[J].吉林大学学报(医学版),2007,33(2):353-355.
Yang Q,Liu ZY,Liu SS,et al.Relationship between blood serum IgGand hepatic fibrosis in patients with chronic hepatitis B and hepatocirrhosis[J].Journal of Jilin University(Medicine Edition),2007,33(2):353-355.
[10] 李 彩.免疫球蛋白水平对乙肝患者的临床意义[J].中国卫生检验杂志,2016,26(12):1747-1748,1751.
Li C.Clinical significance of serum immunoglobulin levels for hepatitis Bpatients[J].Chinese Journal of Health Laboratory Technology,2016,26(12):1747-1748,1751.

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备注/Memo

备注/Memo:
作者简介:马 莹(1983-),女,本科,主管检验师,主要从事临床免疫学检验工作,E-mail:754634927@qq.com。
通讯作者:赵 佳(1984-),女,博士,副主任检验师,主要从事临床免疫及分子生物学检验工作,E-mail: 84911zj@163.com。
更新日期/Last Update: 2018-09-30