[1]梅方超,戴海英,尚小玲,等.尿液HBP,LE,U-NIT和WBC联合检测与尿液细菌定量培养对急性尿道感染的诊断意义[J].现代检验医学杂志,2018,33(05):126-128.[doi:10.3969/j.issn.1671-7414.2018.05.035]
　MEI Fang-chao,DAI Hai-ying,SHANG Xiao-ling,et al.Diagnostic Significance of Urine HBP,LE,U-NIT and WBC Combined with Urine Bacterial Quantitative Culture in the Diagnosis of Acute Urethral Infection[J].Journal of Modern Laboratory Medicine,2018,33(05):126-128.[doi:10.3969/j.issn.1671-7414.2018.05.035]
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尿液HBP,LE,U-NIT和WBC联合检测与尿液细菌定量培养对急性尿道感染的诊断意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年05期
页码:
126-128
栏目:
论著
出版日期:
2018-11-18

文章信息/Info

Title:
Diagnostic Significance of Urine HBP,LE,U-NIT and WBC Combined with Urine Bacterial Quantitative Culture in the Diagnosis of Acute Urethral Infection
文章编号:
1671-7414(2018)05-126-03
作者:
梅方超1; 戴海英1; 尚小玲1; 2; 汪宏良1; 2
1.黄石市中心医院医学检验科,湖北黄石 435000; 2.肾脏疾病发生与干预湖北省重点实验室,湖北黄石 435000
Author(s):
MEI Fang-chao1; DAI Hai-ying1; SHANG Xiao-ling1; 2; WANG Hong-liang1; 2
1.Department of Clinical Laboratory Medicine,Huangshi Central Hospital,Hubei Huangshi 435000,China; 2.Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention,Hubei Huangshi 435000,China
关键词:
肝素结合蛋白;  联合检测;  急性尿道感染;  诊断意义
分类号:
R446.12; R446.5
DOI:
10.3969/j.issn.1671-7414.2018.05.035
文献标志码:
A
摘要:
目的 探讨尿液肝素结合蛋白(HBP)、白细胞酯酶(LE)、尿亚硝酸盐(U-NIT)和白细胞计数(WBC)联合检测与尿液细菌定量培养对急性尿道感染的诊断意义。方法 收集2017年1～12月在黄石市中心医院确诊的98例急性尿道感染患者为病例组(诊断结果以患者出院时诊断为准),选取同年龄段、同时间段来医院体检的健康患者95例作为对照组,分别在不同时间段留取对照组、治疗前病例组和治疗后病例组患者尿液标本10 ml于无菌塑料管中(治疗前病例组所有病例均为患者入院还未进行任何治疗,治疗后病例组所有病例均为患者入院后接受治疗病情已基本稳定),留取的尿液标本均在1 h内进行HBP,LE,U-NIT和WBC检测及细菌定量接种,对动态监测的结果进行统计学分析。结果 治疗前病例组与对照组比较,差异有统计学意义(P<0.01); 治疗后病例组与治疗前病例组比较,差异均有统计学意义(P<0.01); 五项联合检测在不同时间段敏感度、特异度和准确度均高于单项检测及四项联合检测,差异均有统计学意义(P<0.01),约登指数(敏感度+特异度-1)最高为0.81。结论尿液HBP,LE,U-NIT和WBC联合检测与尿液细菌定量培养对急性尿道感染快速诊断具有很高的临床价值。
Abstract:
Objective To explore the diagnostic significance of urine HBP,LE,U-NIT and WBC combined with urine bacterial culture in thediagnosis of acute urethral infection.Methods 98 cases of acute urinary tract infection were collected as the case group in Huangshi City Central Hospital from January to December 2017,and selected 95 healthy patients of the same age group and the same time period who came to the hospital for physical examination as the control group.10 ml urine samples from patients in the conteol group and the case group were collected at different time periods in sterile plastic tubes.All urine samples were tested for HBP,LE,U-NIT,WBC and Quantiative inoculation of bacteria within 1 h,and the results of dynamic monitoring were statistically analyzed.Results Compared with thecontrol group before treatment,the level of five indicators was significantlyhigher,and the difference was statistically significant(P<0.01).Comparedwith the pre-treatment group,the level of the five indicators decreased significantly,and the difference was statistically significant(P<0.01).Five joint detection sensitivity at different times,specific degrees and accuracy were higher than single detection and four joint detection,the difference was statistically significant(P<0.01),some index(sensitivity+ specificity-1)upto 0.81.Conclusion Urine HBP,LE,U-NIT,WBC and urine bacterial quantitative culture have high clinical value for rapid diagnosis ofacute urethral infection.

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备注/Memo

备注/Memo:
作者简介:梅方超(1985-),男,硕士,主管技师,主要从事临床基础检验工作,E-mail:280542194@qq.com。
通讯作者:汪宏良,男,硕士研究生导师,主任技师,主要从事临床免疫学研究,E-mail:jy69970@163.com。
更新日期/Last Update: 2018-09-30