[1]焦荣红a,沈海涛,王淑芬a,等.类风湿关节炎患者血清淀粉样蛋白A和C反应蛋白水平与疾病活动度的关系[J].现代检验医学杂志,2019,34(01):55-57,61.[doi:10.3969/j.issn.1671-7414.2019.01.014]
　JIAO Rong-honga,SHEN Hai-tao,WANG Shu-fe na,et al.Relationship between Serum Amyloid A and C-reactive Protein in Patients with Rheumatoid Arthritis and Activity of Disease[J].Journal of Modern Laboratory Medicine,2019,34(01):55-57,61.[doi:10.3969/j.issn.1671-7414.2019.01.014]
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类风湿关节炎患者血清淀粉样蛋白A和C反应蛋白水平与疾病活动度的关系()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年01期
页码:
55-57,61
栏目:
论著
出版日期:
2019-02-28

文章信息/Info

Title:
Relationship between Serum Amyloid A and C-reactive Protein in Patients with Rheumatoid Arthritis and Activity of Disease
文章编号:
1671 -7414(2019)01-055-04
作者:
焦荣红1a; 沈海涛2; 王淑芬1a; 房华1a ; 陈奕吉1a; 陈蕊华1b
(1.上海市浦东新区人民医院a.检验科； b.内分泌科，上海201299；2.上海中医药大学附属第七人民医院检验科，上海 200137)
Author(s):
JIAO Rong-hong1a; SHEN Hai-tao2; WANG Shu-fe n1a; FANG Hua1a; CHEN Yi-ji1a;  CHEN Rui-hua1b
( 1a .Department of Clinical Laboratory ； 1b .Department of Endocrinology，Shanghai Pudong New Area People’s Hospital ，Shanghai 201299，China；2.Department of Clinical Laboratory，the Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine，Shanghai 200137，Chin a)
关键词:
血清淀粉样蛋白A; C反应蛋白; 类风湿关节炎; 疾病活动度;  相关性
分类号:
R593.22；R446.112
DOI:
10.3969/j.issn.1671-7414.2019.01.014
文献标志码:
A
摘要:
目的探讨类风湿关节炎(RA)患者血清淀粉样蛋白A(SAA)和 C反应蛋白(CRP)与疾病活动度的相关性。方法检测210例RA患者(RA 组)、100健康体检者(对照组)的SAA，CRP及红细胞沉降率(ESR)等实验室指标，根据疾病活 动指数(DAS 28)将RA组分为活动期(97例，DAS 28≥2.6分)和缓解期(113例，DAS 28<2.6 分)，根据影像学结果分为骨损伤88例和无骨损伤122例。比较不同病情活动度患者SAA 和CRP水平变化，及SAA，CRP与DAS 28的相关性。结果缓解期RA组 血清SAA水平(136.07±22.14 μg/L)显著高于对照组(108.54±13.28 μg/L)，差异有 统计学意义( t=10.75，P <0.05)，而两组CRP水平(4.63±2.16 mg/L vs　4.16±1 .28 mg/L)比较，差异无统计学意义( t=0.78，P >0.05)。活动期RA组血清SAA(611.4 6±62.77 μg/L)，CRP(34.63±4.88 mg/L)显著高于对照组和缓解期RA组，差异有统计 学意义( t=69.65，55.13，P <0.05)。骨损伤患者血清SAA(587.23±60.36 μg/L v s 147.55±13.18 μg/L)，CRP(30.48±4.27 mg/L vs 4.85±1.38 mg/L)较无骨损伤 患者明显升高，差异有统计学意义( t=67.15，50.27，P <0.05)。缓解期 患者DAS 28评分与SAA呈显著正相关( r=0.372，P <0.05)，而与CRP无显著相关性( r= 0.289，P >0.05)。活动期患者DAS28评分与SAA，CRP均呈显著正相关( r=0.414，0.3 42，均P <0.05)。RA患者血清SAA与CRP呈显著正相关( r=0.428，P <0.05)。 结论SAA在RA患者中明显升高，与CRP，DAS28评分相关性好，SAA联合CRP可 作为疾病活动状态的敏感指标。
Abstract:
Objective To explore the correlation of serum a myloid A(SAA) and C-reactive protein(CRP) and activity of rheumatoid arthritis (RA)．Methods Laboratory indexes such as SAA，CRP and blo od sedimentation (ESR) were detected in 210 patients with RA (RA group)，100 hea lthy physical examination (control group)．According to the disease activity ind ex (DAS 28)，RA group was divided into active period ( n =97，DAS 28≥2.6) an d remission period ( n =113，DAS 28<2.6)．According to the imaging results，R A group was divided into patients with bone erosion ( n =88) and patients with out bone erosion ( n =122)．The changes of SAA and CRP levels in patients with different disease activity and the correlation between SAA and CRP and DAS 28 w ere compared．Results The level of SAA(136.07±22.14 μg/L) in RA group was significantly higher than that in control group (108 .54±13.28 μg/L)( t=10.75，P <0.05) respectively，while CRP level (4.63 ±2.16 mg/L vs　4.16±1.28 mg/L) was not statistically significant between tw o groups ( t=0.78，P >0.05) respectively．The levels of SAA (611.46±62.77 μg/L)and CRP (34.63±4.88 mg/L)in active RA group were　significantly high er than those in control group and remission RA group ( t=69.65，55.13，P <0 .05)respectively．The levels of SAA and CRP were significantly higher in patien ts with bone injury (587.23±60.36 μg/L，30.48±4.27 mg/L) than those w ith out bone injury (147.55±13.18 μg/L)，(4.85±1.38 mg/L) ( P <0. 05) respectlvey．The DAS28 score in remissi on patients showed a significant positive correlation with SAA ( r=0.372，P < 0.05)，but no significant correlation with CRP ( r=0.289，P >0.05)．The DAS 28 score of active patients was significantly positively correlated with serum S AA and CRP ( r=0.414，0.342，P <0.05)．SAA and CRP of RA patients showed si gnificant positive correlation ( r=0.428，P <0.05)．Conclusion SAA is significantly increased in RA patients，and correlated well wi th CRP and DAS 28 scores．SAA combined with CRP could be used as a sensitive ind icator of disease activity status．

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备注/Memo

备注/Memo:
基金项目：上海市卫生和计划生育委员会(编号：201640207)。
作者简介：焦荣红(1980-)，女，本科，主管技师，研究方向：临 床免疫检测，E-mail：582929891@qq.com。
通讯作者：陈蕊华，E-mail：mizuno@yeah.net
更新日期/Last Update: 2019-02-28