[1]张求霞a,汪隆海a,昌国庆a,等.尿液6种蛋白与CysC水平检测对糖尿病肾病的诊断价值[J].现代检验医学杂志,2019,34(01):67-71.[doi:10.3969/j.issn.1671-7414.2019.01.017]
　ZHANG Qiu-xiaa,WANG Long-haia,CHANG Guo-qing a,et al.Clinical Value of Detection of 6 Proteins and Cystatin C in Urine for Early Diagnosis of Diabetic Kidney Disease[J].Journal of Modern Laboratory Medicine,2019,34(01):67-71.[doi:10.3969/j.issn.1671-7414.2019.01.017]
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尿液6种蛋白与CysC水平检测对糖尿病肾病的诊断价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年01期
页码:
67-71
栏目:
论著
出版日期:
2019-02-28

文章信息/Info

Title:
Clinical Value of Detection of 6 Proteins and Cystatin C in Urine for Early Diagnosis of Diabetic Kidney Disease
文章编号:
1671- 7414(2019)01-067-05
作者:
张求霞a; 汪隆海a; 昌国庆a; 黄飞a; 唐丽群a;  姚芹梅a; 王勇b; 姜中云b
(宋庆龄爱心医院a.检验科；b.肾内科，安徽巢湖238000)
Author(s):
ZHANG Qiu-xiaa; WANG Long-haia; CHANG Guo-qing a; HUANG Feia; TANG Li-quna;  YAO Qin-meia; WANG Yongb; JIANG Zhong-yunb
( a .Depar tment of Clinical Laboratory； b .Department of Nephrology，Song Qingling Caring Hospital，Anhui Chao hu 238000，China)
关键词:
蛋白质; 胱抑素C; 糖尿病肾病; 糖尿病; 诊断
分类号:
R587.2；R446.122
DOI:
10.3969/j.issn.1671-7414.2019.01.017
文献标志码:
A
摘要:
目的探讨尿液6种蛋白与尿Cys C对糖尿病肾病(DKD)的诊 断价值。方法测定41例DKD患者、47例DM患者、53例健康体检者和3 9例DM控制不佳患者的尿液6种蛋白与尿Cys C水平，并运用IBM SPSS23.0软件对结果进行统 计处理。结果DKD患者的尿液Cys C，NGAL，α1-MG，β2-MG，TR F，RBP和mALB结果都明显高于DM患者和健康体检者， P 值均为0.000。它们的ROC曲线下 面积分别为0.989，0.991，0.988，0.994，0.988，0.991和0.990。用尿液的CysC≥ 0.255 mg/L，NGAL≥98.5 μg/L，α1-MG≥11.55 mg/L，β2-MG≥0.44 mg/L，TRF≥ 3.15 mg/L，RBP≥1.325 mg/L和mALB≥22.5 mg/L的7项之2诊断DKD，敏感度为97.56%， 特异度为98.04%。在DM患者控制不佳的情况下可提高46.15%的DKD诊断。结论 尿液Cys C，NGAL，α1-MG，β2-MG，TRF和RBP的联合检测可对DKD患者作早 期诊断。DKD患者的尿液Cys C，NGAL，α1-MG，β2-MG，TRF和RBP升高均早于mALB，联合 检测可减少DKD诊断的漏诊率。
Abstract:
Objective To investigate the diagnostic value o f urinary 6 proteins and cystatin C (Cys C) detection in patients with diabetic kidney disease (DKD)．Methods Urine levels of 6 proteins and Cys C were measured in：41 patients with DKD，47 patients with diabetes mel litus (DM)，53 case of healthy checkup and 39 patients poorly controlled DM．IBM SPSS 23.0 software was employed for statistical analysis in this study． Results The levels of urinary Cys C，neutrophil gelatinase-as sociated lipocalin (NGAL)，α1-microglobulin (α1-MG)，β2 -microglobulin (β 2-MG)，transferrin (TRF)，retinol binding protein (RBP) and microalbumin (mALB) in DKD patients were significantly higher than the DM and healthy subjects． P 　values all were 0.000．Their receiver operator characteristic curve (ROC) s howed that area under curve (AUC) were 0.989，0.991，0.988，0.994，0.988，0 .991 and 0.990，respectively．Diagnosis of DKD was performed using urine Cys C ≥0.255 mg/L，NGAL≥98.5 μg/L，α1-MG≥11.55 mg/L，β2-MG≥0.44 mg/L，TRF ≥3.15 mg/L，RBP≥1.325 mg/L and mALB≥22.5 mg/L in 7 items 2．The sensitivit y and specificity were 97.56% and 98.04% respectively with their two results t o diagnose D KD．The DKD diagnosis could be improved by 46.15% in case for poor control of D M patients．Conclusion Combined test of urine Cys C，NGAL ，α1-MG，β2-MG，TRF and RBP can make early diagnosis for patients with DKD． The increase of urine Cys C，NGAL，α1-MG，β2-MG，TRF and RBP in patients wit h DKD were earlier than mALB，and combined detection can reduce the rate for mis sed diagnosis of DKD．

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备注/Memo

备注/Memo:
作者 简介：张求霞(1979-)，女，本科在读，主管检验师，从事临床化学工作与研究， E-mail：2206660739@qq.com。
通讯作者：汪隆海(1957-)，男，大专，副主任检验师，从事临床 化学工作与研究，E-mail：wlhgh@126.com。
更新日期/Last Update: 2019-02-28