[1]梁 彦,张沛欣,冯苗苗.青少年肥胖患者血清可溶性尿激酶型纤溶酶原激活物受体检测的临床意义[J].现代检验医学杂志,2019,34(02):68-71.[doi:10.3969/j.issn.1671-7414.2019.02.018]
　LIANG Yan,ZHANG Pei-xin,FENG Miao-miao.Study on Detection of Serum Soluble Urokinase Activator Receptorin Obese Adolescents[J].Journal of Modern Laboratory Medicine,2019,34(02):68-71.[doi:10.3969/j.issn.1671-7414.2019.02.018]
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青少年肥胖患者血清可溶性尿激酶型纤溶酶原激活物受体检测的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年02期
页码:
68-71
栏目:
论著
出版日期:
2019-05-11

文章信息/Info

Title:
Study on Detection of Serum Soluble Urokinase Activator Receptorin Obese Adolescents
文章编号:
1671-7414(2019)02-068-04
作者:
梁 彦1; 张沛欣2; 冯苗苗3
(1.铜川市人民医院肾脏内分泌科,陕西铜川 727000; 2.空军军医大学唐都医院肾脏内分泌科,西安 710038; 3.西安市杨家村第三军队离退休干部休养所卫生所内科,西安 710061)
Author(s):
LIANG Yan1; ZHANG Pei-xin2; FENG Miao-miao3
(1.Department of Endocrinology,Tongchuan People's Hospital,Shaanxi Tongchuan,727000,China; 2.Department of Endocrinology,Tangdu Hospital of Air ForceMilitaryMedical University,Xi'an 710038,China; 3.Department of Medicine,Health Center for Retired Cadres o
关键词:
可溶性尿激酶型纤溶酶原激活物受体;  青少年;  肥胖
分类号:
Q983.23; R446.11
DOI:
10.3969/j.issn.1671-7414.2019.02.018
文献标志码:
A
摘要:
目的 探讨可溶性尿激酶型纤溶酶原激活物受体(suPAR)作为新炎症标志物在青少年肥胖患者中的作用。方法 招募120例年龄在12～17岁之间的青少年入组,肥胖青少年60例为试验组,健康青少年60例为对照组。采用酶联免疫吸附测定法检测血清瘦素、脂联素,suPAR,IL-6和纤维蛋白原。结果试验组青少年的suPAR,瘦素、白细胞介素-6(IL-6)、超敏C反应蛋白(hsCRP)及纤维蛋白原水平均明显高于对照组(t=4.319～12.398,均P<0.05); 试验组血清脂联素水平明显低于对照组(t=3.664,P<0.05)。ROC分析结果显示血清suPAR区分肥胖青少年与对照组的ROC曲线下面积为0.85,显著大于脂联素及IL-6(Z=2.655,2.030,均P<0.05),小于瘦素(Z=2.012,P<0.05)。血清suPAR区分肥胖青少年与对照组的最佳临界值为4.53 μg/ml,对应的敏感度为67%,特异度为90%。结论 青少年肥胖患者血清suPAR显著升高,其可能成为肥胖相关的全身亚临床炎症反应及免疫激活的新型生物标志物。
Abstract:
Objective To evaluate the role of suPAR in adolescent obesity.Methods Total of 120 participants,60 obese individuals and 60 healthy controls,aged between 10 and 17 year,were included in the study.Serum suPAR,IL-6,leptin and adiponectin were measured usingELISA method.Results Serum suPAR,IL-6,fbrinogen,hsCRPand leptin levels in obese individuals were significantly higher than those ofcontrols(t=4.319～12.398,all P<0.05).Serum adiponectin levels in obese individuals were signifcantly lower than those of controls(t=3.664,P<0.05).The area under the ROC curve of suPAR was higher than that of adiponectin and IL-6(Z=2.655 and 2.030,all P<0.05),and lower than that of leptin(Z=2.012,P<0.05).The sensitivity and the specificity were 67% and 90% respectively while the cut-off values were 4.53 μg/ml.Conclusion Serum suPAR was signifcantly higher in the obese individuals thanthose of controls.SuPAR may be a good novel biomarker for systemic subclinicalin ammation and immune activation linked to adolescent obesity.

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备注/Memo

备注/Memo:
基金项目:陕西省自然科学基金项目(2013JM4016)。 作者简介:梁 彦(1983-),女,硕士研究生,研究方向:肾脏内分泌,E-mail:tcrmyyliangyan@163.com。 通讯作者:冯苗苗(1984-),女,E-mail:519928430@qq.com。 收稿日期:2018-12-24 修回日期:2019-02-11
更新日期/Last Update: 2019-04-30