[1]陈小娟a,邱敏娟a,高 飞a,等.广州地区孕妇尿碘水平与甲状腺功能减退的相关性分析[J].现代检验医学杂志,2019,34(02):119-121.[doi:10.3969/j.issn.1671-7414.2019.02.030]
　CHEN Xiao-juana,QIU Min-juana,GAO Feia,et al.Analysis of the Correlation between Urinary Iodine Leveland Hypothyroidism in Pregnant Women in Guangzhou[J].Journal of Modern Laboratory Medicine,2019,34(02):119-121.[doi:10.3969/j.issn.1671-7414.2019.02.030]
点击复制

广州地区孕妇尿碘水平与甲状腺功能减退的相关性分析()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年02期
页码:
119-121
栏目:
检验与临床
出版日期:
2019-05-11

文章信息/Info

Title:
Analysis of the Correlation between Urinary Iodine Leveland Hypothyroidism in Pregnant Women in Guangzhou
文章编号:
1671-7414(2019)02-119-04
作者:
陈小娟a; 邱敏娟a; 高 飞a; 李 飞b; 郑 浩a; 蔡敏敏a
(广州市妇女儿童医疗中心a.珠江新城院区检验科; b.产前诊断科,广州 510623)
Author(s):
CHEN Xiao-juana; QIU Min-juana; GAO Feia; LI Feib; ZHENG Haoa; CAI Min-mina
(a.Department of Clinical Laboratory,Zhujiang New Town; b.Department of Prenatal Diagnosis,Guangzhou Women and Children's Medical Center,Guangzhou 510623,China)
关键词:
妊娠;  尿碘;  甲状腺功能
分类号:
R714.147; R446.122
DOI:
10.3969/j.issn.1671-7414.2019.02.030
文献标志码:
A
摘要:
目的 分析广州地区妊娠期妇女的碘营养状况,探讨其与甲状腺功能减退的关系。方法 随机选取2017年1～12月于广州市妇女儿童医疗中心产科门诊进行产检的孕妇4 986例,对其空腹血清促甲状腺激素(TSH)、游离甲状腺激素(FT4)、甲状腺过氧化物酶抗体(TPOAb)及尿碘(UI)水平进行回顾性分析。结果 4 896例孕妇尿碘水平为5～1 476 μg/L,中位数为179.3 μg/L,碘缺乏、碘适量、碘超足量和碘过量的发生率分别为39.93%,28.42%,18.99%和12.66%。随着尿碘水平的升高,TSH和FT4水平随之升高,差异具有统计学意义(χ2=20.19,P=0.001; χ2=16.45,P=0.000); 三组甲状腺功能异常在不同碘营养状态的发生率差异无统计学意义(χ2=4.08,P=0.67); TPOAb的阳性率为24.11%,其在三组甲状腺疾病中的阳性率差异具有统计学意义(χ2=10.18,P=0.006)。结论 广州地区妊娠期碘不足或碘过量较为常见,维持适量的尿碘水平对预防甲状腺功能异常有重要意义。
Abstract:
Objective To investigate the association of urinary iodine nutritional of pregnant women with hypothyroidism in Guangzhou.Methods A total of 4 986 pregnant women were enrolled from January 2017 to December,and retrospectively analyzed their urinary iodine level(UI)and thyroid function index(included TSH,FT4 and TPOAb).Results The range of urine iodine level in pregnant women was 5～1 476 μg/L,the urine iodine median was 179.3 μg/L,the iodine deficiency,iodine in moderation,iodine adequate enough,and the incidence of iodine excess were 39.93%,28.42%,18.99% and 12.66%,respectively.With the increase of urinary iodine,the levels of TSH and FT4 increased,and the difference was statistically significant(χ2=20.19,P=0.001; χ2=16.45,P=0.000).The incidence of hypothyroidism,subclinical hypothyroidism and low thyroid hormone levels were 0.14%,0.62% and 2.05%,respectively.Compared three groups of thyroid disease incidence in different urinary iodine levels,there was no statistically significant(χ2=4.08,P=0.67).The positive rate of TPOAb was 24.11%,and compared the positive rate of TPOAb between three group thyroid disease,there was statistically significant(χ2=10.18,P=0.006).Conclusion Iodine deficiency or excess during pregnancy is common in Guangzhou.Maintaining adequate urinary iodine level is of great significance in preventing thyroid dysfunction.

参考文献/References:

[1] WHO,UNICEF,ICCIDD.Assessment of iodine deficiency disorders and monitoring their elimination[S].3rd ed.Geneva:Switzerland,World Health Organization,2007.
[2] 丁榕,范建霞.美国甲状腺学会《2017年妊娠及产后甲状腺疾病诊治指南》解读[J].中华围产医学杂志,2017,20(3):165-169. DING Rong,FAN Jianxia.American Interpretation of Guidelines of the Thyroid Association for the diagnosis and management of thyroid diseases during pregnancy and the postpartum in 2017[J].Chinese Journal of Perinatal Medicine,2017,20(3):165-169.
[3] 赵霞,唐婕,吴韶清,等.妊娠期碘营养状态与甲状腺功能的关系研究[J].国际检验医学杂志,2017,38(11):1490-1492. ZHAO Xia,TANG Jie,WU Shaoqing,et al.Study on iodine nutrition and thyroid function in pregnant women[J].International Journal of Laboratory Medicine,2017,38(11):1490-1492.
[4] DEMIRKAYA M,KELSAKA E,SARIH-ASAN B,et al.The optimal dose of remifentanil for acceptable intubating conditions during propofol induction without neuromuscular blockade[J].J Clin Anesth,2012,24(5):392-397.
[5] 王晓雪,贾方,田晶,等.妊娠期碘营养、甲状腺自身抗体与甲状腺功能关系的研究[J].中华内分泌代谢杂志,2014,30(5):408-410. WANG Xiaoyue,JIA Fang,TIAN Jing,et al.Iodine nutrition and thyroid autoantibodies in pregnancy and their relation to thyroid function[J].Chinese Journal of Endocrinology and Metabolism,2014,30(5):408-410.
[6] 杨金,郑合明,李小烽,等.河南省碘缺乏地区孕妇碘营养及甲状腺功能变化的纵向研究[J].中华流行病学杂志,2015,36(1):35-39. YANG Jin,ZHENG Heming,LI Xiaofeng,et al.A longitudinal study regarding the gestational changes in iodine nutrition and thyroid function among pregnant women in the iodine deficient areas of Henan province[J].Chinese Journal of Epidemiology,2015,36(1):35-39.
[7] 李晨嫣,单忠艳.妊娠期碘营养与甲状腺功能[J].中华地方病学杂志,2016,35(3):161-165. LI Chenyan,SHAN Zhongyan.Iodine intake and thyroid function during pregnancy[J].Chinese Journal of Endemiology,2016,35(3):161-165.
[8] 赵树君,孙富军,田恩江,等.碘缺乏和碘过量对甲状腺自身免疫影响的实验研究[J].中华预防医学杂志,2006,40(1):18-20. ZHAO Shujun,SUN Fujun,TIAN Enjiang,et al.Experimental study oneffects of iodine deficiency and excess on thyroid autoimmunity[J].Chinese Journal of Preventive Medicine,2006,40(1):18-20.
[9] STAGNARO-GREEN A.Approach to the patient wi-th postpartum thyroiditis[J].Journal of Clinical Endocrinology & Metabolism,2012,97(2):334-342.
[10] 叶文慧,何柳瑜,吕小飞,等.妊娠早期合并亚临床甲状腺功能减退妇女自身抗体阳性对不良妊娠结局的影响[J].实用妇产科杂志,2018,34(1):34-37.YE Wenhui,HE Liuyu,L(¨overU)Xiaofei,et al.The impact of subclinicalhypothyroidism combined with autoantibody positive in first trimester of pregnancy on pregnancy outcomes[J].Journal of Practical Obstetrics and Gynecology,2018,34(1):34-37.
[11] 徐艳红,吴艺捷,罗越,等.孕妇血清甲状腺过氧化物酶抗体阳性对妊娠结局的影响[J].中华内分泌代谢杂志,2012,28(5):377-381.XU Yanhong,WU Yijie,LUO Yue,et al.Influence of positive serum thyroidperoxidase antibody on pregnancy outcomes[J].Chinese Journal of Endocrinologyand Metabolism, 2012,28(5):377-381.

相似文献/References:

[1]谭婷婷,陈雨欣,程 莉,等.不同妊娠期妇女碘营养状况与甲状腺功能检测研究[J].现代检验医学杂志,2017,32(03):115.[doi:10.3969/j.issn.1671-7414.2017.03.031]
　TAN Ting-ting,CHEN Yu-xin,CHENG Li,et al.Investigation of Iodine Nutritional Status and Thyroid Function in Pregnant Women During Different Periods[J].Journal of Modern Laboratory Medicine,2017,32(02):115.[doi:10.3969/j.issn.1671-7414.2017.03.031]
[2]张 洁,寇 莹,马 丽,等.正常孕妇不同孕期甲状腺功能参考范围的分析研究[J].现代检验医学杂志,2017,32(03):144.[doi:10.3969/j.issn.1671-7414.2017.03.040]
　ZHANGJie,KOU Ying,MA Li,et al.Reserch on the Tlyroid Function Reference Range of Different Pregnancy Period of Normal Pregnant Women[J].Journal of Modern Laboratory Medicine,2017,32(02):144.[doi:10.3969/j.issn.1671-7414.2017.03.040]
[3]申文娟,李园春,姚若冰.孕前和孕期母体外周血血红蛋白浓度与发生胎儿死产风险的相关性研究[J].现代检验医学杂志,2019,34(04):139.[doi:10.3969/j.issn.1671-7414.2019.04.034]
　SHEN Wen-juan,LI Yuan-chun,YAO Ruo-bing.Correlation between Maternal Peripheral Blood Hemoglobin Concentration and Risk of Fetal Stillbirth before and During Pregnancy[J].Journal of Modern Laboratory Medicine,2019,34(02):139.[doi:10.3969/j.issn.1671-7414.2019.04.034]
[4]杨荣荣,张 萍.外周血液狼疮抗凝物质比值及Ｔ细胞免疫球蛋白黏蛋白分子３水平与孕早期复发性流产的相关性研究[J].现代检验医学杂志,2020,35(01):60.[doi:10.3969/j.issn.1671-7414.2020.01.016]
　YANG Rong-rong,ZHANG Ping.Study on the Relationship between Ratio of Lupus Anticoagulant and Levels of T-cell Immunoglobulin-Mucin Molecule 3 in Peripheral Blood and Recurrent Abortion in Early Pregnancy[J].Journal of Modern Laboratory Medicine,2020,35(02):60.[doi:10.3969/j.issn.1671-7414.2020.01.016]
[5]马 润,沈秀芬,陈孝红,等.昆明地区不同妊娠期妇女甲状腺功能指标参考区间的调查及变化分析[J].现代检验医学杂志,2020,35(01):97.[doi:10.3969/j.issn.1671-7414.2020.01.026]
　MA Run,SHEN Xiu-fen,CHEN Xiao-hong,et al.nvestigation and Change Analysis of Reference Intervals ofThyroid Function Indicators for Women at Different Stages of Pregnancy in Kunming[J].Journal of Modern Laboratory Medicine,2020,35(02):97.[doi:10.3969/j.issn.1671-7414.2020.01.026]
[6]黄明兰,柯晓斯,彭致平,等.正常妊娠期妇女低色素性贫血对糖化血红蛋白水平检测的影响[J].现代检验医学杂志,2021,36(02):151.[doi:doi:10.3969/j.issn.1671-7414.2021.02.036]
　HUANG Ming-lan,KE Xiao-si,PENG Zhi-ping,et al.Effect of Hypopigmentation Anemia on Glycosylated Hemoglobin in Normal Pregnant Women[J].Journal of Modern Laboratory Medicine,2021,36(02):151.[doi:doi:10.3969/j.issn.1671-7414.2021.02.036]
[7]周莉莉,刘 栋,宋宏庆.陕西省铜川地区妊娠妇女血清甲状腺激素水平参考范围的建立及临床应用[J].现代检验医学杂志,2022,37(05):164.[doi:10.3969/j.issn.1671-7414.2022.05.032]
　ZHOU Li-li,LIU Dong,SONG Hong-qing.Establishment and Clinical Application of Reference Intervals of Serum Thyroid Hormone Level of Pregnant Women in Tongchuan[J].Journal of Modern Laboratory Medicine,2022,37(02):164.[doi:10.3969/j.issn.1671-7414.2022.05.032]
[8]龙 琴,石安惠,黄佳蓉.四川宜宾地区不同孕期妇女血浆可溶性纤维蛋白单体复合物水平参考范围的建立[J].现代检验医学杂志,2024,39(01):166.[doi:10.3969/j.issn.1671-7414.2024.01.031]
　LONG Qin,SHI Anhui,HUANG Jiarong.Establishment of Reference Ranges for Plasma Soluble Fibrin Monomer Complex Level at Different Gestational Periods of Women in Yibin Area of Sichuan[J].Journal of Modern Laboratory Medicine,2024,39(02):166.[doi:10.3969/j.issn.1671-7414.2024.01.031]

备注/Memo

备注/Memo:
作者简介:陈小娟(1973-),女,本科,副主任技师,从事临床生化专业,E-mail:cxjandhzx@163.com。 收稿日期:2018-09-26 修回日期:2019-01-19 页码：121+124
更新日期/Last Update: 2019-04-30