[1]权青云,赵 敏,张贵云,等.老年高脂血症患者血清HbA1c,HCY水平与认知功能障碍的关系[J].现代检验医学杂志,2019,34(03):134-136.[doi:10.3969/j.issn.1671-7414.2019.03.034]
 QUAN Qing-yun,ZHAO Min,ZHANG Gui-yun,et al.Relationship between Glycosylated Hemoglobin,Homocysteine Levelsand Cognitive Impairment in Elderly Patients with Hyperlipidemia[J].Journal of Modern Laboratory Medicine,2019,34(03):134-136.[doi:10.3969/j.issn.1671-7414.2019.03.034]
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老年高脂血症患者血清HbA1c,HCY水平与认知功能障碍的关系()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年03期
页码:
134-136
栏目:
检验与临床
出版日期:
2019-06-20

文章信息/Info

Title:
Relationship between Glycosylated Hemoglobin,Homocysteine Levelsand Cognitive Impairment in Elderly Patients with Hyperlipidemia
文章编号:
1671-7414(2019)03-134-03
作者:
权青云赵 敏张贵云张克举孙 鹃张 愉
(武警陕西省总队医院干部病房,西安 710054)
Author(s):
QUAN Qing-yunZHAO MinZHANG Gui-yunZHANG Ke-juSUN JuanZHANG Yu
(Wards for Offices,Shaanxi Armed Police Corps Hospital,Xi'an710054,China)
关键词:
高脂血症 糖化血红蛋白 同型半胱氨酸 认知功能障碍
分类号:
R749.16; R446.112
DOI:
10.3969/j.issn.1671-7414.2019.03.034
文献标志码:
A
摘要:
目的 探讨老年高脂血症患者糖化血红蛋白(glycosylatedhemoglobin,HbA1c)、同型半胱氨酸(homocysteine,HCY)与认知功能障碍的相关性。方法 将2017年1月~2018年10月就诊武警陕西总队医院的高脂血症患者228例纳入研究,检测患者HbA1c和HCY。依据简易智力量表评分(MMSE)及蒙特利尔认知评分(MoCA)检测结果,分为无认知障碍(169例)和认知障碍组(59例)。结果 认知障碍组HbA1c显著高于无认知障碍组(5.12%±1.73% vs 4.51%±1.12%),差异有统计学意义(t=-3.121,P=0.002),认知障碍组HCY显著高于无认知障碍组(11.18±3.60 mmol/L vs 10.32±1.25 mmol/L),差异有统计学意义(t=-2.670,P=0.004)。结论 HbA1c,HCY与认知功能障碍的发生有密切的关系,提示在高脂血症患者中,应重视监测HbA1c和HCY并进行积极干预,对认知功能障碍的发生有重要的临床意义。
Abstract:
Objective To investigate the correlation between glycosylated hemoglobin(HbA1c), Homocysteine(HCY)and cognitive impairmentin elderly patients with hyperlipidemia(HLP).Methods 228hyperlipidemia patients admitted to Shaanxi Armed Police Corps Hospital from January 2017 to October 2018 were included in the study,HbA1c and HCY were detected.According to the mini-mental state examination(MMSE)and Montreal cognitive assessment scale(MoCA),the patients were divided into two groups,169 caseswithout cognitive impairment and 59 cases with cognitive impairment.Results HbA1c in the cognitive impairment group was significantly higher than the non-cognitive impairment group(5.12%±1.73% vs 4.51%±1.12%,t=-3.121,P=0.002).HCY in the cognitive impairment group was significantly higher than the non-cognitive impairment group(11.18±3.60 mmol/L vs 10.32±1.25 mmol/L,t=-2.670,P=0.004)respectively.Conclusion HbA1c and HCY were closely related to the occurrence of cognitiveimpairment,suggesting that in patients with HLP,it is of great clinical significance to pay attention to the monitoring of HbA1c and HCY and carry out activeintervention for the occurrence of cognitive impairment.

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备注/Memo

备注/Memo:
基金项目:武警陕西总队医院科研立项,项目编号:YNKYLX-2017005。 作者简介:权青云(1973-),女,在读博士,副主任医师,研究方向:神经病学和老年病学,E-mail:13669261090@163.com。 通讯作者:张 愉(1977-),女,学士,主治医师,研究方向:老年病学,E-mail: 1583094500@qq.com。 收稿日期:2019-04-03 修回日期:2019-04-28
更新日期/Last Update: 2019-06-20