[1]刘 娅,贺 巧,佘佳琪.宫颈癌患者治疗前血浆凝血四项指标与生存率的相关性研究[J].现代检验医学杂志,2019,34(03):137-139,143.[doi:10.3969/j.issn.1671-7414.2019.03.035]
　LIU Ya,HE Qiao,SHE Jia-qi.Correlation between the Four Indicators of Coagulation andPrognosis in Patients with Cervical Carcinoma before Treatment[J].Journal of Modern Laboratory Medicine,2019,34(03):137-139,143.[doi:10.3969/j.issn.1671-7414.2019.03.035]
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宫颈癌患者治疗前血浆凝血四项指标与生存率的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年03期
页码:
137-139,143
栏目:
检验与临床
出版日期:
2019-06-20

文章信息/Info

Title:
Correlation between the Four Indicators of Coagulation andPrognosis in Patients with Cervical Carcinoma before Treatment
文章编号:
1671-7414(2019)03-137-04
作者:
刘 娅1; 贺 巧2; 佘佳琪3
(1.重庆医科大学附属第二医院检验科,重庆 400010; 2.四川省肿瘤医院检验科,成都 610041; 3.达州市中心医院检验科,四川达州635000)
Author(s):
LIU Ya1; HE Qiao2; SHE Jia-qi3
(1.Department of Clinical Laboratory,the Second AffiliatedHospital of Chongqing Medical University,Chongqing 400010,China; 2.Department ofClinical Laboratory,Sichuan Cancer Hospital,Chengdu 610041,China; 3.Departmentof Clinical Laboratory,Dazhou Central Hospital,Sichuan Dazhou 635000,China)
关键词:
凝血四项;  宫颈癌;  预后
分类号:
R737.33; R730.43
DOI:
10.3969/j.issn.1671-7414.2019.03.035
文献标志码:
A
摘要:
目的 探讨宫颈癌患者治疗前凝血四项指标与生存率的关系。方法 回顾性分析2009年12月31日～2017年1月1日四川省肿瘤医院收治的264例初诊宫颈癌患者的临床资料。采用Kaplan-Meier(K-M)生存分析法分析治疗前的凝血四项指标对其生存时间的影响。结果 治疗前血浆凝血酶原时间(prothrombintime,PT)、活化部分凝血活酶时间(activated partial thromboplatin time,APTT)、凝血酶时间(thrombin time,TT)和纤维蛋白原(fipinogen,FIB)是宫颈癌患者总生存时间的独立危险因素(P<0.05)。APTT(P=0.035,HR=0.31,95%CI:0.1～0.98),PT(P=0.008 5,HR=2.79,95%CI:1.26～6.19),FIB(P=0.004 6,HR=2.32,95%CI:1.21～3.92)和TT(P=0.013,HR=0.51,95%CI:0.29～0.88)。结论 宫颈癌患者治疗前凝血四项与生存率密切相关,对于其预后评估有重要意义。
Abstract:
Objective To investigate the relationship between the four indicators of coagulation and prognosis in patients with cervical carcinoma before treatment.Methods A total of 264 patientswere randomly selected at Sichuan Cancer Hospital from 2009.12.31 to 2017.1.1.The levels of APTT,PT,TT and FIB in serum were obtained through electronic medical records.Survival analyses were plotted by the Kaplan-Meier method.Results Four indicators of coagulation were correlated with the prognosis of cervical cancer(P<0.05).APTT(P=0.035,HR=0.31,95%CI:0.1～0.98),PT(P=0.008 5,HR=2.79,95%CI:1.26～6.19),FIB(P=0.004 6,HR=2.32,95%CI:1.21～3.92)and TT(P=0.013,HR=0.51,95%CI:0.29～0.88).Conclusion APTT,PT,FIB and TT are reliable indicators for evaluating the prognosis of cervical carcinoma.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:刘 娅(1994-),女,本科,医学学士,检验技师,研究方向:临床血液检验及研究,E-mail:BAJULIA@163.com。 通讯作者:佘佳祺(1994-),男,本科,检验技师,研究方向:临床血液检验及研究。 收稿日期:2019-03-03修回日期:2019-04-18
更新日期/Last Update: 2019-06-20