[1]张慧雅,魏建勋,刘秋霞.孕妇血清可溶性B7-H4水平与胎膜早破早产之间的关系研究[J].现代检验医学杂志,2019,34(03):140-143.[doi:10.3969/j.issn.1671-7414.2019.03.036]
　ZHANG Hui-ya,WEI Jian-xun,LIU Qiu-xia.Relationship between Serum Soluble B7-H4 Leveland Premature Rupture of Membrane in Pregnant Women[J].Journal of Modern Laboratory Medicine,2019,34(03):140-143.[doi:10.3969/j.issn.1671-7414.2019.03.036]
点击复制

孕妇血清可溶性B7-H4水平与胎膜早破早产之间的关系研究()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年03期
页码:
140-143
栏目:
检验与临床
出版日期:
2019-06-20

文章信息/Info

Title:
Relationship between Serum Soluble B7-H4 Leveland Premature Rupture of Membrane in Pregnant Women
文章编号:
1671-7414(2019)03-140-04
作者:
张慧雅1; 魏建勋2; 刘秋霞1
(1.西电医院妇产科,西安 710077; 2.延安大学附属医院产科,陕西延安 716000)
Author(s):
ZHANG Hui-ya1; WEI Jian-xun2; LIU Qiu-xia1
(1.Department of Obstetrics and Gynecology,Xidian Hospital,Xi'an 710077,China; 2.Departmentof Obstetrics,Affiliated Hospital of Yan'an University,Shaanxi Yan'an716000,China)
关键词:
未足月胎膜早破;  可溶性B7-H4;  酶联免疫吸附测定
分类号:
R714.433; R446.61
DOI:
10.3969/j.issn.1671-7414.2019.03.036
文献标志码:
A
摘要:
目的 探讨孕妇血清可溶性B7-H4(soluble B7-H4,sB7-H4)浓度和未足月胎膜早破(preterm premature rupture of membranes,pPROM)之间的关系。方法 研究纳入41例患者,其中未足月胎膜早破组患者22例、足月胎膜早破(premature rupture of membranes,PROM)组患者19例; 同时纳入35例健康妊娠女性为对照组; 采用酶联免疫吸附测定受试者妊娠11～13周时血清中sB7-H4的浓度。结果 pPROM组患者血清中sB7-H4的浓度高于PROM组患者和对照组女性,其差异均有统计学意义(P<0.05); 区分pPROM组患者与对照组患者的sB7-H4临界值为13.01 ng/ml,特异度为96.5%,敏感度为62.1%。结论 pPROM组患者妊娠早期血清中sB7-H4的浓度既可预示母胎交互作用时的动态免疫反应程度,也可作为妊娠并发症的预测指标。
Abstract:
Objective To investigate relationship between serum soluble B7-H4(sB7-H4)and preterm premature rupture of membranes(pPROM)in pregnant women.Methods The study included 41 patients, 22 cases in preterm premature rupture of membranes(pPROM)group,19 cases in premature rupture of membranes(PROM)group,and included 35 healthy pregnantwomen(control group).Maternal serum levels of sB7-H4 were determined with enzyme-linked immunosorbent assay(ELISA)in patients between 11 and 13 weeks' gestation.Results Serum concentrations of sB7-H4 in the pPROM group were higher than those in the PROM group and the control group,the differences were statistically significant(all P<0.05).The ability to discriminate between pPROM cases and controls with anoptimal thresholdof 13.01 ng/ml,specificity of 96.5% and sensitivity of 62.1%.Conclusion Serum concentration of sB7-H4 in early pregnancy in patients with pPROM may not only indicate the degree of dynamics immune response duringmaternal-fetal interaction,but also serve as a predictor of pregnancy complications.

参考文献/References:

[1] AMY EF,ROBERTO R,TARA NM,et al.Human chorionic gonadotropin has anti-inflammatory effects at the maternal-fetal interface and prevents endotoxin-induced preterm birth,but causes dystocia and fetal compromise in mice[J].Biol Reprod,2016,94(6):136.
[2] SCHUMACHER A,ZENCLUSSEN AC.Effects of heme oxygenase-1 on innate andadaptive immune responses promoting pregnancy success and allograft tolerance[J].Front Pharmacol,2014,5:288.
[3] 张赟,李娅,郭旭昌,等.胎膜早破孕妇生殖道感染病原菌的分布及耐药性分析[J].现代检验医学杂志,2015,30(3):98-100. ZHANG Yun,LI Ya,GUO Xuchang,et al.Distribution and drug resistance of genital tract pathogenic bacteria in pregnant women with premature ruptureof membrane[J].J Mod Lab Med,2015,30(3):98-100.
[4] 王君莲,孙江川,常淑芳.未足月胎膜早破的治疗进展[J].重庆医学,2014,43(15):1951-1953. WANG Junlian,SUN Jiangchuan,CHANG Shufang.Progress in the treatment of premature rupture of membranes in immature fetuses[J].Chongqing Medicine,2014,43(15):1951-1953.
[5] 李小侠,解娟,詹颉,等.围产期胎膜早破与生殖道病原菌感染的分析[J].现代检验医学杂志,2016,31(4):90-92. LI Xiaoxia,XIE Juan,ZHAN Jie,et al.Analysis of perinatal premature rupture of membranes and reproductive tract pathogen infection[J].J Mod Lab Med,2016,31(4):90-92.
[6] 秦江霞,贾金平,岳玉焕.未足月胎膜早破患者阴道菌群微生态的评价[J].中国计划生育和妇产科,2014,6(2):28-30,34. QIN Jiangxia,JIA Jinping,YUE Yuhuan.Microecological evaluation ofvaginal microflora in pregnant women with preterm premature rupture of membranes[J].Chinese Journal of Family Planning & Gynecotokology,2014,6(2):28-30,34.
[7] 杨筱青,郭华峰,杨俊娟.未足月胎膜早破孕妇生殖道感染及潜伏期对母婴结局的影响[J].中国妇幼保健,2014,29(33):5455-5457. YANG Xiaoqing,GUO Huafeng,YANG Junjuan.Effects of reproductive tract infection and incubation period on maternal and infant outcomes in women with premature rupture of membranes[J].Maternal & Child Health Care of China,2014,29(33):5455-5457.
[8] 薛会灵,刘金,梁玲,等.未足月胎膜早破产妇胎膜组织中TLR2表达变化及意义[J].山东医药,2014,54(18):8-9. XUE Huiling,LIU Jin,LIANG Ling.Expression changes of TLR2 in fetal membranes of patients with preterm premature rupture of membranes and the significance[J].Shandong Medical Journal,2014,54(18):8-9.
[9] LOGIODICE F,LOMBARDELLI L,KULLOLLI O,et al.Decidual interleukin-22-producing CD4+ T cells(Th17/Th0/IL-22+ and Th17/Th2/IL-22+,Th2/IL-22+,Th0/IL-22+),which also produce IL-4,are involved in the success of pregnancy[J].Int J Mol Sci,2019,20(2):428.
[10] XIE Nan,CAI Jiabin,ZHANG Lu,et al.Upregulation of B7-H4 promotes tumor progression of intrahepatic cholangiocarcinoma[J].Cell Death Dis,2017,8(12):3205.
[11] LEANDERSSON P,KALAPOTHARAKOS G,HE-NIC E,et al.A biomarker panelincreases the diagnostic performance for epithelial ovarian cancer Type I and II inyoung women[J].Anticancer Res,2016,36(3):957-965.
[12] SMITH JB,LANITIS E,DANGAJ D,et al.Tumor regression anddelayed onset toxicity following B7-H4 CAR-T cell therapy[J].Mol Ther,2016,24(11):1987-1999.
[13] RADICHEN I A,MANEVA-RADICHEVA L V,AMATYA C,et al.Loss of peripheralprotection in pancreatic islets by proteolysis- driven impairment of VTCN1(B7-H4)presentation is associated with the development of autoimmune diabetes[J].J Immunol,2016,196(4):1495-1506.
[14] XIAO Zexiu,ZHENG Xu,HU Li,et al.Immunosuppressive effect of B7-H4pathway in a murine systemic lupus erythematosus model[J].Front Immunol,2017,8:1765.
[15] TARCA A L,FITZGERALD W,CHAEMSAITHO-NG P,et al.The cytokine networkin women with an asymptomatic short cervix and the risk of preterm delivery[J].Am J Reprod Immunol,2017,78(3):e12686.
[16] 廖晓燕,陈艺菲.基质金属蛋白酶-8、白细胞介素-6水平与早产关系的研究[J].华西医学,2015,30(3):480-483.LIAO Xiaoyan,CHEN Yifei.The correlation of amniotic fluids levels and blood serum levels of matrix metalloproteinases-8 and interleukin-6 with pretermdelivery[J].West China Medical Journal,2015,30(3):480-483.

相似文献/References:

[1]张春艳,乔山峰.未足月胎膜早破并发组织型绒毛膜羊膜炎孕妇血液SII 与Presepsin 水平及其诊断价值分析[J].现代检验医学杂志,2024,39(03):147.[doi:10.3969/j.issn.1671-7414.2024.03.025]
　ZHANG Chunyan,QIAO Shanfeng.Analysis of the Diagnostic Value of Blood SII and Presepsin for Histological Chorioamnionitis in Pregnant Women with Preterm Premature Rupture of Membranes[J].Journal of Modern Laboratory Medicine,2024,39(03):147.[doi:10.3969/j.issn.1671-7414.2024.03.025]

备注/Memo

备注/Memo:
基金项目:陕西省教育厅自然科学研究项目(项目编号:2013JK0773)。 作者简介:张慧雅(1984-),女,本科,主治医师,研究方向:妇科肿瘤治疗和产后的康复治疗,E-mail:zhanghuiyaxidian@163.com。 通讯作者:刘秋霞(1981-),女,硕士,主治医师,E-mail:liuqiuxia0516@163.com。 收稿日期:2019-01-02 修回日期:2019-04-01
更新日期/Last Update: 2019-06-20