[1]蒋秋丽,王佩红,苗群英,等.宫颈鳞癌患者癌组织Nemo样激酶的表达与临床病理特征及预后关系研究[J].现代检验医学杂志,2019,34(05):72-76.[doi:10.3969/j.issn.1671-7414.2019.05.018]
　JIANG Qiu-li,WANG Pei-hong,MIAO Qun-ying,et al.Expression of NLK in Cervical Squamous Cell Carcinoma and Its Clinical Significance[J].Journal of Modern Laboratory Medicine,2019,34(05):72-76.[doi:10.3969/j.issn.1671-7414.2019.05.018]
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宫颈鳞癌患者癌组织Nemo样激酶的表达与临床病理特征及预后关系研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年05期
页码:
72-76
栏目:
论著
出版日期:
2019-10-29

文章信息/Info

Title:
Expression of NLK in Cervical Squamous Cell Carcinoma and Its Clinical Significance
文章编号:
1671-7414(2019)05-072-05
作者:
蒋秋丽1; 王佩红1; 苗群英1; 白 宁1; 樊阳阳2
(1.汉中市中心医院妇科,陕西汉中 723000; 2.陕西省人民医院妇产科,西安 710068)
Author(s):
JIANG Qiu-li1; WANG Pei-hong1; MIAO Qun-ying1; BAI Ning1; FAN Yang-yang2
(1.Department of Gnaecology,Hanzhong Central Hospital,Shaanxi Hanzhong 723000,China; 2.Department of Obstetrics and Gynecology,Shaanxi Provincial People's Hospital,Xi'an 710068,China)
关键词:
宫颈鳞癌;  Nemo样激酶;  预后
分类号:
R737.33; R730.43
DOI:
10.3969/j.issn.1671-7414.2019.05.018
文献标志码:
A
摘要:
目的 探讨宫颈鳞癌患者癌组织Nemo样激酶(NLK)的表达与临床病理特征及预后关系。方法 收集2016～2017年汉中市中心医院172例宫颈癌患者的肿瘤组织标本,采用免疫组织化学方法检测病理组织中Nemo样激酶的表达。应用Log-Rank检验比较低表达患者与高表达患者间的生存时间差异。应用COX模型探索宫颈癌患者预后的影响因素。结果 所有肿瘤组织标本中,有76例(44.19%)为NLK低表达,96例(55.81%)为高表达。NLK表达情况在不同血管/淋巴结浸润状态、不同淋巴结转移情况及不同肿瘤复发情况的人群间进行比较,差异均有统计学意义(χ2=9.01, P=0.003; χ2=9.11, P=0.003; χ2=7.81,P=0.005)。NLK低表达水平的患者平均无疾病生存时间为76.41个月,NLK高表达水平的患者平均无疾病生存时间为53.24个月,NLK低表达水平患者与高表达水平患者间无疾病生存时间比较,差异有统计学意义(χ2=12.36,P<0.001); NLK低表达水平的患者总体生存时间为76.41个月,NLK高表达水平的患者总体生存时间为56.05个月,NLK低表达水平患者与高表达水平患者间总体生存时间比较,差异有统计学意义(χ2=7.84,P=0.005)。COX模型结果表明宫颈鳞癌患者病理组织中NLK高度表达是患者预后的风险因素(HR=2.91)。结论 Nemo样激酶的表达在宫颈鳞癌发生、发展中起重要的作用,并且与患者预后有密切的关系。这提示干预Nemo样激酶的表达可能成为延缓或控制宫颈鳞癌发展的可行方法。
Abstract:
Objective To investigate the relationship between the expression of Nemo-like kinase(NLK)in cervical squamous cell carcinomaand its clinical features and prognosis.Methods From 2016 to 2017,tumor tissue samples of 172 patients with cervical cancer were collected in Hanzhong Central Hospital,and the expression of NLK in pathological tissues was detected by immunohistochemistry.Log-Rank test was used tocompare the survival time between patients with low expression of NLK and thosewith high expression of NLK.The COX model was applied to investigate the prognostic factors of cervical squamous cell carcinoma.Results Among all tumor tissue specimens,76 cases(44.19%)showed low expression ofNLK.High expression was observed in 96 cases(55.81%).NLK expression wascompared among patients with different vascular/lymph node infiltration,lymph node metastasis and tumor recurrence,and the differences were statistically significant(χ2 =9.01,P=0.003; χ2=9.11,P=0.003; χ2 =7.81,P=0.005).Patients with low NLK expression had an average disease-free survival time of 76.41months.Patients with high expression level of NLK had an average disease-freesurvival time of 53.24 months.Disease-free survival time of patients with lowexpression level of NLK was compared with those with high expression level,and the difference was statistically significant(χ2 =12.36,P<0.001).The overall survival time of patients with low NLK expression was 76.41 months,and that of patients with high NLK expression was 56.05 months.The differences in the overall survival time between patients with low NLK expression and those with high NLK expression were statistically significant(χ2=7.84,P=0.005).COX model results indicated that the high expression of NLK in the pathological tissues of patients with cervical squamous cell carcinoma was a risk factor for the prognosis of patients(HR=2.91).Conclusion The expression of Nemo-like kinase in the hair of cervical squamous cell carcinoma health and development play an important role and are closely related to theprognosis of patients.This suggests that intervention of Nemo-like kinase expression may be a feasible method for delaying or controlling the development ofcervical squamous cell carcinoma.

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备注/Memo

备注/Memo:
作者简介:蒋秋丽,女(1972-),本科,副主任医师,研究方向:妇科肿瘤,E-mail: hanjiangqiul@163.com。
更新日期/Last Update: 2019-10-20