[1]赵培斐,张晓芬,陈亚宁.血清β-HCG,CRP水平检测结合子宫动脉血流超声指标对胎儿宫内窘迫及宫内感染的诊断价值[J].现代检验医学杂志,2019,34(05):89-92.[doi:10.3969/j.issn.1671-7414.2019.05.022]
　ZHAO Pei-fei,ZHANG Xiao-fen,CHEN Ya-ning.Diagnostic Value of Serum β-HCG,CRP Level Combinedwith Uterine Artery Blood Flow Ultrasound Index for Intrauterine Distress and Intrauterine Infection[J].Journal of Modern Laboratory Medicine,2019,34(05):89-92.[doi:10.3969/j.issn.1671-7414.2019.05.022]
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血清β-HCG,CRP水平检测结合子宫动脉血流超声指标对胎儿宫内窘迫及宫内感染的诊断价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年05期
页码:
89-92
栏目:
论著
出版日期:
2019-10-29

文章信息/Info

Title:
Diagnostic Value of Serum β-HCG,CRP Level Combinedwith Uterine Artery Blood Flow Ultrasound Index for Intrauterine Distress and Intrauterine Infection
文章编号:
1671-7414(2019)05-089-05
作者:
赵培斐1; 张晓芬2; 陈亚宁2
(1.渭南市第一医院检验科,陕西渭南 714000; 2.陕西省潼关县人民医院产科,陕西渭南 714399)
Author(s):
ZHAO Pei-fei1; ZHANG Xiao-fen2; CHEN Ya-ning2
(1.Department of Clinical Laboratory,Weinan First Hospital,Shaanxi Weinan 714000,China; 2.Department of Obstetrics,Tongguan County People's Hospital,Shaanxi Weinan 714399,China)
关键词:
子宫动脉血流;  β-人绒毛膜促性腺激素;  C反应蛋白;  宫内窘迫;  宫内感染
分类号:
R714.43; R446.112
DOI:
10.3969/j.issn.1671-7414.2019.05.022
文献标志码:
A
摘要:
目的 探究血清β-人绒毛膜促性腺激素(β-HCG)、C反应蛋白(CRP)水平检测结合子宫动脉血流超声指标对胎儿宫内窘迫及宫内感染的诊断价值。方法 采取回顾性分析的方式,选择2017年1月～2018年1月医院收治的妊娠期出现胎儿宫内窘迫或宫内感染的121例产妇为实验组,选择同时期医院收治的妊娠期正常的231例产妇为对照组。使用多普勒超声诊断仪检测两组产妇的子宫动脉血流搏动指数(PI)、阻力指数(RI)、收缩期血流速度与舒张期血流速度比值(S/D)。用化学发光法检测血清β-HCG水平,免疫比浊法检测血清CRP水平。采用统计学分析方法对比两组产妇子宫动脉PI,RI,S/D,血清β-HCG及CRP水平变化情况。分别以PI=0.96,RI=0.46,S/D=2.16,β-HCG=50 μg/ml,CRP=20 mg/L为界值预测不良妊娠结局的敏感度、特异度和准确度。结果 实验组产妇子宫动脉PI,RI及S/D值分别为1.21±0.34,0.69±0.21和2.69±0.68,均明显高于对照组(0.82±0.31,0.43±0.11和2.06±0.51),差异均具有统计学意义(t=10.840,12.735,8.957,均P<0.001)。实验组产妇血清β-hCG,CRP水平分别为91.23±10.22 μg/ml和34.65±6.55 mg/L,均明显高于对照组(36.56±6.53 μg/ml和13.26±5.11 mg/L),差异具有统计学意义(t=53.408,31.280,均P<0.001)。PI,RI,S/D,β-HCG和CRP联合检测预测不良妊娠结局的灵敏度、特异度和准确度分别为91.67%,90.98%和91.19%,均高于各单项检测,差异具有统计学意义(χ2=48.531,25.210,76.043,均P<0.05)。结论 子宫动脉PI,RI,S/D及血清β-HCG,CRP水平检测在胎儿宫内窘迫及宫内感染的诊断中具有良好的应用价值,在一定程度上可以预测不良妊娠结局,具有较好的临床诊断价值。
Abstract:
Objective To explore the diagnostic value of serum human chorionic gonadotropin(β-HCG),C-reactive protein(CRP)level combined with uterine artery blood flow ultrasound index for intrauterine distress and intrauterine infection.Methods A retrospective analysis was conducted to select 121 pregnant women who had intrauterine distress or intrauterine infection during pregnancy from January 2017 to January 2018.The 231 women who were pregnant during the same period of pregnancy were selected as the control group.Doppler ultrasound was used to detect the uterine artery bloodflow pulsation index(PI),resistance index(RI), systolic blood flow velocityand diastolic blood flow velocity ratio(S/D).Serum β-HCG levels were measured again by chemiluminescence,and serum CRP levels were measured by immunoturbidimetry.Statistical analysis was used to compare the changes of PI,RI,S/D,serum β-HCG and CRP levels in the uterine arteries of the two groups.The sensitivity,specificity and accuracy of adverse pregnancy outcomes were predicted byPI=0.96,RI=0.46,S/D=2.16,β-HCG=50 μg/ml and CRP=20 mg/L.Results The PI,RI and S/D values of the uterine artery in the experimental group were 1.21±0.34,0.69±0.21 and 2.69±0.68,respectively,which were significantly higher than the control group(0.82±0.31,0.43±0.11and 2.06±0.51),respectively.The differences were statistically significant(t=10.840,12.735,8.957,all P<0.001).The serum levels of β-HCGand CRP in the experimental group were 91.23±10.22 μg/ml and 34.65±6.55 mg/L,respectively,which were significantly higher than the control group(36.56±6.53 μg/ml and 13.26±5.11 mg/L),respectively,the difference was statistically significant(t=53.408,31.280,all P<0.001).The sensitivity,specificity and accuracy of combined detection of PI,RI,S/D,β-HCG and CRPin predicting adverse pregnancy outcomes were 91.67%,90.98% and 91.19%,respectively,both higher than the individual tests,and the differences were statistically significant(χ2=48.531,25.210,76.043,all P<0.05).Conclusion Uterine artery PI,RI,S/D and serum β-HCG,CRPlevels have a good application value in the diagnosis of intrauterine distressand intrauterine infection.They can predict adverse pregnancy outcomes to a certain extent and have good clinical diagnostic value.

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备注/Memo

备注/Memo:
作者简介:赵培斐(1981-),男,本科,主管检验师,研究方向:医学检验,E-mail:zpf8688@163.com。 通讯作者:张晓芬(1970-),女,大专,主治医师,研究方向:产科危重症和出血的救治,E-mail:zxf15891083115@163.com。
更新日期/Last Update: 2019-10-20