[1]赵智凝,黄黎明,李 鹏.纹带棒状杆菌感染临床特征及耐药性分析[J].现代检验医学杂志,2019,34(05):106-108.[doi:10.3969/j.issn.1671-7414.2019.05.026]
　ZHAO Zhi-ning,HUANG Li-ming,LI Peng.Clinical Distribution and Drug Resistance of Corynebacterium Striatum[J].Journal of Modern Laboratory Medicine,2019,34(05):106-108.[doi:10.3969/j.issn.1671-7414.2019.05.026]
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纹带棒状杆菌感染临床特征及耐药性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年05期
页码:
106-108
栏目:
论著
出版日期:
2019-10-29

文章信息/Info

Title:
Clinical Distribution and Drug Resistance of Corynebacterium Striatum
文章编号:
1671-7414(2019)05-106-04
作者:
赵智凝; 黄黎明; 李 鹏
(中国人民解放军空军第九八六医院,西安 710054)
Author(s):
ZHAO Zhi-ning; HUANG Li-ming; LI Peng
(the 986 Hospital of the Chinese People's Liberation Army Air Force,Xi'an 710054,China)
关键词:
纹带棒状杆菌;  药物敏感性试验;  最低抑菌浓度
分类号:
R378; R446.5
DOI:
10.3969/j.issn.1671-7414.2019.05.026
文献标志码:
A
摘要:
目的 分析纹带棒状杆菌感染的临床特征及对常用抗生素的耐药情况,为临床合理用药提供实验室依据。方法 收集2017年3月～2018年12月临床标本中分离的纹带棒状杆菌42株,鉴定采用法国生物梅里埃公司VITEK-2compact全自动微生物鉴定仪及配套的厌氧菌-棒状杆菌(ANC)鉴定卡。用微量肉汤稀释法检测20种抗生素的最低抑菌浓度(MIC)。结果 42株纹带棒状杆菌主要来源为下呼吸道标本(83.3%),分离率以老年病科最高(35.7%)。万古霉素、利萘唑胺及利福平对纹带棒状杆菌有较高的敏感率,庆大霉素、红霉素和阿奇霉素等次之,而β-内酰胺酶类抗生素对纹带棒状杆菌耐药率都在90%以上,其他抗生素如亚胺培南、美罗培南、环丙沙星、左氧氟沙星、克林霉素和四环素等敏感率较低。结论 纹带棒状杆菌在临床标本中的分离率增高,多侵犯免疫力低下人群,分离株多为多药耐药菌株,万古霉素、利萘唑胺和利福平为临床首选用药。
Abstract:
Objective To analyzed the clinical characteristics of Corynebacterium striatum infection and its resistance to commonly used antibiotics,so as to provide laboratory evidence for rational drug therapy.Methods A total of 42 strains of C.striatum were collected from clinical specimens from Mar.2017 to Dec.2018.The identification wascarried out by VITEK-2 compact automatic microbial identification instrument and ancillary anaerobic-corynebacterium(ANC)identification card.Minimum inhibitory concentration(MIC)of 20 antimicrobial agents was determined by broth microdilution method.Results Most of the 42 Corynebacterium striatum strains were lower respiratory tract specimens(83.3%),with the highest detection rate(35.7%)in geriatrics.Vancomycin,linezolid and rifampicin were more sensitive to C.striatum,followed by gentamicin,erythromycinand azithromycin,while beta-lactamase antibiotics were more than 90% resistantto C.striatum.Other antibiotics such as imipenem,meropenem,ciprofloxacin,levofloxacin,clindamycin and tetracycline were also less sensitive.Conclusion Corynebacterium striatum isolation rate in clinical specimens increased,mostly invaded the people with low immunity.Most isolates were multidrug-resistant strains.Vancomycin,linezolid and rifampicin wouldbe the first choice for clinical treatment.

参考文献/References:

[1] SAVINI V,GHERARDI G,FAVARO M,et al.About a bloodstream Corynebacterium striatum isolate[J].Folia Microbiol(Praha),2013,58(6):451-453. [2] DE ARRIBA J J,BLANCH J J,MATEOS F,et al.Corynebacterium striatum firstreported case of prosthetic valve endocarditis[J].J Infect,2002,44(3):193. [3] RENOM F,GOMILA M,GARAU M,et al.Soriano respiratory infection by Corynebacterium striatum:epidemiological and clinical determinants[J].New Microbes New Infect,2014,2(4):106-114. [4] WERTH B J,HAHN W O,BUTLER-WU SM,et al.Emergence of high-level daptomycin resistance in Corynebacterium striatum in two patients with left ventricular assist device infections[J].Microb Drug Resist,2016,22(3):233-237. [5] RIDAURA V K,BOULADOUX N,CLAESEN J,et al.Contextual control of skin immunity and inflammation by Corynebacterium[J].J Exp Med,2018,215(3):785-799. [6] MATTOS-GUARALDI A L, GUIMARAES L C, SANTOS C S,et al.Draft genome sequence of Corynebacterium striatum 1961 BR-RJ/09,a multidrug-susceptiblestrain isolated from the urine of a hospitalized 37-tyear-old female patient[J].Genome Announc,2015,3(4):e00869-15. [7] WESTBLADE L F,SHAMS F,DUONG S,et al.Septic arthritis of a native kneejoint due to Corynebacterium striatum[J].J Clin Microbiol,2014,52(5):1786-1788. [8] 孙伟,李亚娜,苏建荣.棒状杆菌属细菌感染的流行病学特点和药物敏感性分析[J].临床和实验医学杂志,2018,17(20):2228-2231. SUN Wei,LI Yana,SU Jianrong.Study on the epidemiological featuresand drug sensitivity of Corynebacterium spp bacterial infection[J].Journal of Clinical and Experimental Medicine,2018,17(20):2228-2231. [9] RENOM F,GOMILA M,GARAU M,et al.Respiratory infection by Corynebacterium striatum:epidemiological and clinical determinants[J].New Microbes New Infect,2014,2(4):106-114. [10] WANG Junrui,WANG Yanyan,DU Xiaoli,et al.Rapid transmission of multidrug-resistant Corynebacterium striatum among susceptible patients in a tertiary hospital in China[J].J Infect Dev Ctries,2016,10(12):1299-1305. [11] 汪一萍,应建飞,俞燕红,等.32株纹带棒杆菌的感染及其耐药分析[J].中华医院感染学杂志,2008,18(10):1454-1455. WANG Yiping,YING Jianfei,YU Yanhong,et al.Identification and resistance analysis of 32 strains of Corynebacterium striatum clinical isolates[J].Chinese Journal of Nosocomiology,2008,18(10):1454-1455. [12] 陈东科,许宏涛,艾晓曼,等.临床分离棒状杆菌对常用抗菌药物的敏感性分析[J].临床检验杂志,2011,29(3):191-192. CHEN Dongke,XU Hongtao,AI Xiaoman,et al.Antibiotic susceptibility ofCorynebacterium isolated from clinical specimens[J].Chinese Journal Clinical Laboratory Science,2011,29(3):191-192. [13] 杨雪静,曹俊敏,孙西铃.纹带棒状杆菌的分离鉴定及方法学评价[J].检验医学,2008,23(1):114. YANG Xuejing,CAO Junmin,SUN Xiling.Isolati-on,identification and methodological evaluation of Corynebacterium striatum[J].Laboratory Medicine,2008,23(1):114. [14] 陈东科,沙丽嗒娜提·贺纳亚提,许宏涛,等.纹带棒杆菌在临床标本中的分布及耐药性调查[J].中华医院感染学杂志,2010,20(2):285-287. CHEN Dongke,SHALITANAT Hetnayat,XU Ho-ngtao,et al.Distribution and drugresistance of Corynebacterium striatum in clinical specimens[J].ChineseJournal of Nosocomiology,2010,20(2):285-287. [15] 曹俊敏,杨雪静,王原.棒杆菌属细菌分类鉴定的方法学比较及对四环素与大环内酯类抗菌药物耐药机制的研究[J].中华医院感染学杂志,2013,23(2):241-244. CAO Junmin,YANG Xuejing,WANG Yuan.Methodology of identification of Corynebacterium and the drug resistance mechanisms to tetracycline and macrolides antibiotics[J].Chinese Journal of Nosocomiology,2013,23(2):241-244. [16] ALIBI S,FERJANI A,BOUKADIDA J,et al.Occurrence of Corynebacteriumstriatum as an emerging antibiotic-resistant nosocomial pathogen in a Tunisian hospital[J].Sci Rep,2017,7(1):9704. [17] GALIMAND M,FISHOVITZ J,LAMBERT T,et al.AAC(3)-XI,a new aminoglycoside 3-N-acetyltransferase from Corynebacterium striatum[J].Antimicrob Agents Chemother,2015,59(9):5647-5653.

备注/Memo

备注/Memo:
作者简介:赵智凝(1975-),女,博士,主治医师,研究方向:临床微生物检验及耐药机制研究,E-mail:shirley_zzn@sina.com。
更新日期/Last Update: 2019-10-20